Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03119:Fyttd1'

409910

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fyttd1

Ensembl Gene

ENSMUSG00000022800

Gene Name

forty-two-three domain containing 1

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.152) question?

Stock #

IGL03119

Quality Score

Status

Chromosome

Chromosomal Location

32877500-32908875 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 32900695 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 121 (V121A)

Ref Sequence

ENSEMBL: ENSMUSP00000155929 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023489] [ENSMUST00000120345] [ENSMUST00000171325] [ENSMUST00000232272]

AlphaFold

Q91Z49

Predicted Effect

probably benign
Transcript: ENSMUST00000023489
AA Change: V239A

PolyPhen 2 Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000023489
Gene: ENSMUSG00000022800
AA Change: V239A

Domain	Start	End	E-Value	Type
Pfam:FYTT	10	317	1.7e-176	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000120345
AA Change: V51A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000113541
Gene: ENSMUSG00000022800
AA Change: V51A

Domain	Start	End	E-Value	Type
Pfam:FYTT	2	129	1e-83	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125843

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127493

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135854

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137863

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141590

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145146

Predicted Effect

probably benign
Transcript: ENSMUST00000171325

SMART Domains

Protein: ENSMUSP00000131446
Gene: ENSMUSG00000022800

Domain	Start	End	E-Value	Type
Pfam:FYTT	3	210	6.8e-137	PFAM
Pfam:FYTT	209	283	4.6e-48	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231751

Predicted Effect

probably benign
Transcript: ENSMUST00000232272
AA Change: V121A

PolyPhen 2 Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232300

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1a	A	G	5: 8,714,887	T626A	probably benign	Het
Adcy1	C	T	11: 7,109,051	T319I	probably damaging	Het
Adgrv1	A	G	13: 81,382,373	S5861P	probably damaging	Het
Adgrv1	A	C	13: 81,433,700	C4742G	probably benign	Het
Arid5b	A	T	10: 68,243,227	D93E	probably damaging	Het
Atp6v1h	A	G	1: 5,095,669	T121A	probably benign	Het
Atxn7	C	T	14: 14,100,734	L807F	probably damaging	Het
Cep104	A	C	4: 153,981,724	K126N	probably damaging	Het
Dcaf6	T	C	1: 165,339,976	E708G	probably damaging	Het
Dst	A	G	1: 34,161,062	Y107C	probably damaging	Het
E2f3	A	G	13: 29,985,365	S102P	probably benign	Het
Eif3e	A	C	15: 43,265,604	S207A	probably benign	Het
Etl4	A	G	2: 20,713,387	Y313C	probably damaging	Het
Gstk1	T	C	6: 42,249,899	S200P	probably damaging	Het
Ifrd1	A	T	12: 40,212,334	F244L	probably null	Het
Ints7	T	C	1: 191,610,365	V491A	probably damaging	Het
Kcnd2	G	T	6: 21,216,509	E71*	probably null	Het
Ltbp3	A	T	19: 5,757,443	Q1123L	probably damaging	Het
Myo5a	A	G	9: 75,174,015	T961A	probably benign	Het
Naa25	T	A	5: 121,434,978	V720E	probably null	Het
Olfr1480	T	C	19: 13,530,435	I298T	probably benign	Het
Olfr599	A	G	7: 103,338,722	I223V	probably damaging	Het
Pcdhb15	C	A	18: 37,475,014	T433N	probably damaging	Het
Peli1	T	C	11: 21,140,560		probably benign	Het
Ptbp1	T	C	10: 79,859,624	V209A	probably damaging	Het
Ranbp2	A	G	10: 58,452,003	Y31C	probably damaging	Het
Smg1	G	A	7: 118,195,113		probably benign	Het
Stat2	A	G	10: 128,283,517	M457V	probably benign	Het
Trpm6	G	T	19: 18,838,017	E1156*	probably null	Het
Usp53	T	A	3: 122,961,415	R130S	possibly damaging	Het
Vwa5b1	A	G	4: 138,606,541	S193P	probably benign	Het
Xrn2	A	G	2: 147,042,872	I626V	probably damaging	Het
Zfp574	G	A	7: 25,080,473	A307T	probably benign	Het

Other mutations in Fyttd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02072:Fyttd1	APN	16	32900661	missense	probably damaging	0.99
R0014:Fyttd1	UTSW	16	32905554	missense	probably damaging	1.00
R0014:Fyttd1	UTSW	16	32905554	missense	probably damaging	1.00
R1742:Fyttd1	UTSW	16	32905553	nonsense	probably null
R5018:Fyttd1	UTSW	16	32902417	critical splice acceptor site	probably null
R5800:Fyttd1	UTSW	16	32891288	missense	probably damaging	1.00
R5893:Fyttd1	UTSW	16	32898913	missense	probably damaging	1.00
R7325:Fyttd1	UTSW	16	32884248	missense	probably benign	0.43
R8146:Fyttd1	UTSW	16	32902492	missense	probably damaging	1.00
R8702:Fyttd1	UTSW	16	32884159	missense	probably damaging	0.99
R9626:Fyttd1	UTSW	16	32905545	missense	probably damaging	1.00
R9649:Fyttd1	UTSW	16	32895102	missense	probably benign	0.02
Z1177:Fyttd1	UTSW	16	32877784	unclassified	probably benign

Posted On

2016-08-02