Incidental Mutation 'IGL03121:Vmn1r67'
| ID |
409973 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r67
|
| Ensembl Gene |
ENSMUSG00000046716 |
| Gene Name |
vomeronasal 1 receptor 67 |
| Synonyms |
V1re10 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
IGL03121
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
10180716-10181714 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 10181394 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 158
(N158K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154237
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055964]
[ENSMUST00000226237]
|
| AlphaFold |
G5E8C1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055964
AA Change: N219K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000060746
Gene: ENSMUSG00000046716
AA Change: N219K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
34 |
292 |
4.3e-31 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226237
AA Change: N158K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B09Rik |
A |
G |
9: 14,672,946 (GRCm39) |
S4P |
possibly damaging |
Het |
| A2m |
A |
G |
6: 121,618,265 (GRCm39) |
N186S |
probably benign |
Het |
| Afg2a |
T |
C |
3: 37,518,800 (GRCm39) |
I778T |
probably damaging |
Het |
| Ago1 |
T |
C |
4: 126,353,796 (GRCm39) |
K261R |
probably benign |
Het |
| Alas1 |
G |
A |
9: 106,124,113 (GRCm39) |
P15L |
probably damaging |
Het |
| Aox1 |
G |
A |
1: 58,398,113 (GRCm39) |
V1285M |
probably damaging |
Het |
| Brd8 |
A |
T |
18: 34,739,740 (GRCm39) |
F678I |
probably damaging |
Het |
| Col27a1 |
T |
A |
4: 63,143,446 (GRCm39) |
M378K |
probably benign |
Het |
| Dpy19l4 |
C |
A |
4: 11,303,334 (GRCm39) |
V196F |
probably damaging |
Het |
| Dst |
G |
T |
1: 34,256,884 (GRCm39) |
|
probably benign |
Het |
| Hsd17b1 |
T |
A |
11: 100,970,870 (GRCm39) |
Y275* |
probably null |
Het |
| Kdm3b |
A |
G |
18: 34,928,762 (GRCm39) |
E171G |
probably damaging |
Het |
| Klc1 |
T |
C |
12: 111,748,076 (GRCm39) |
|
probably benign |
Het |
| Mlkl |
G |
A |
8: 112,041,612 (GRCm39) |
R443W |
probably damaging |
Het |
| Mov10 |
A |
T |
3: 104,708,318 (GRCm39) |
V477E |
probably benign |
Het |
| Nacad |
A |
G |
11: 6,550,933 (GRCm39) |
S753P |
probably damaging |
Het |
| Ncapd2 |
A |
C |
6: 125,150,575 (GRCm39) |
M842R |
probably benign |
Het |
| Nkd2 |
C |
A |
13: 73,969,498 (GRCm39) |
A311S |
probably benign |
Het |
| Nrg1 |
A |
G |
8: 32,314,608 (GRCm39) |
|
probably benign |
Het |
| Or4f6 |
A |
G |
2: 111,838,953 (GRCm39) |
Y193H |
probably benign |
Het |
| Or6c68 |
A |
G |
10: 129,158,037 (GRCm39) |
I182V |
probably benign |
Het |
| Pde6h |
A |
G |
6: 136,936,280 (GRCm39) |
S8G |
probably null |
Het |
| Pik3c2b |
A |
G |
1: 133,007,483 (GRCm39) |
K616E |
probably benign |
Het |
| Pnpt1 |
A |
T |
11: 29,082,845 (GRCm39) |
R54S |
probably benign |
Het |
| Pramel38 |
T |
C |
5: 94,368,912 (GRCm39) |
V469A |
possibly damaging |
Het |
| Rttn |
A |
G |
18: 88,993,875 (GRCm39) |
D184G |
probably damaging |
Het |
| Skint5 |
T |
A |
4: 113,574,284 (GRCm39) |
I756F |
unknown |
Het |
| Slc24a2 |
T |
C |
4: 87,145,143 (GRCm39) |
T304A |
probably benign |
Het |
| Stk3 |
A |
T |
15: 35,099,572 (GRCm39) |
|
probably benign |
Het |
| Trim69 |
A |
G |
2: 121,998,128 (GRCm39) |
I33M |
probably benign |
Het |
| Ube2q2 |
A |
T |
9: 55,102,323 (GRCm39) |
|
probably benign |
Het |
| Wipi2 |
G |
A |
5: 142,648,857 (GRCm39) |
E252K |
probably benign |
Het |
|
| Other mutations in Vmn1r67 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01690:Vmn1r67
|
APN |
7 |
10,180,767 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02812:Vmn1r67
|
APN |
7 |
10,180,945 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03208:Vmn1r67
|
APN |
7 |
10,181,025 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4142001:Vmn1r67
|
UTSW |
7 |
10,180,877 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0048:Vmn1r67
|
UTSW |
7 |
10,180,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Vmn1r67
|
UTSW |
7 |
10,181,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1595:Vmn1r67
|
UTSW |
7 |
10,181,597 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1608:Vmn1r67
|
UTSW |
7 |
10,180,907 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2284:Vmn1r67
|
UTSW |
7 |
10,181,600 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3614:Vmn1r67
|
UTSW |
7 |
10,181,356 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4399:Vmn1r67
|
UTSW |
7 |
10,181,476 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4542:Vmn1r67
|
UTSW |
7 |
10,181,357 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5216:Vmn1r67
|
UTSW |
7 |
10,181,090 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5655:Vmn1r67
|
UTSW |
7 |
10,181,315 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5837:Vmn1r67
|
UTSW |
7 |
10,180,949 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6526:Vmn1r67
|
UTSW |
7 |
10,181,598 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6735:Vmn1r67
|
UTSW |
7 |
10,181,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6846:Vmn1r67
|
UTSW |
7 |
10,180,840 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7086:Vmn1r67
|
UTSW |
7 |
10,181,044 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7227:Vmn1r67
|
UTSW |
7 |
10,181,475 (GRCm39) |
nonsense |
probably null |
|
|
R7594:Vmn1r67
|
UTSW |
7 |
10,181,342 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7608:Vmn1r67
|
UTSW |
7 |
10,181,290 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7797:Vmn1r67
|
UTSW |
7 |
10,180,903 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8681:Vmn1r67
|
UTSW |
7 |
10,181,128 (GRCm39) |
missense |
probably benign |
0.30 |
|
| Posted On |
2016-08-02 |
Incidental Mutation