Incidental Mutation 'IGL03121:Olfr1310'
ID409976
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1310
Ensembl Gene ENSMUSG00000108827
Gene Nameolfactory receptor 1310
SynonymsGA_x6K02T2Q125-73056609-73055671, MOR245-3
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.419) question?
Stock #IGL03121
Quality Score
Status
Chromosome2
Chromosomal Location112004574-112012708 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 112008608 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 193 (Y193H)
Ref Sequence ENSEMBL: ENSMUSP00000149701 (fasta)
Predicted Effect probably benign
Transcript: ENSMUST00000207169
AA Change: Y193H

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000213559
AA Change: Y193H

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B09Rik A G 9: 14,761,650 S4P possibly damaging Het
A2m A G 6: 121,641,306 N186S probably benign Het
Ago1 T C 4: 126,460,003 K261R probably benign Het
Alas1 G A 9: 106,246,914 P15L probably damaging Het
Aox2 G A 1: 58,358,954 V1285M probably damaging Het
Brd8 A T 18: 34,606,687 F678I probably damaging Het
Col27a1 T A 4: 63,225,209 M378K probably benign Het
Dpy19l4 C A 4: 11,303,334 V196F probably damaging Het
Dst G T 1: 34,217,803 probably benign Het
Gm3106 T C 5: 94,221,053 V469A possibly damaging Het
Hsd17b1 T A 11: 101,080,044 Y275* probably null Het
Kdm3b A G 18: 34,795,709 E171G probably damaging Het
Klc1 T C 12: 111,781,642 probably benign Het
Mlkl G A 8: 111,314,980 R443W probably damaging Het
Mov10 A T 3: 104,801,002 V477E probably benign Het
Nacad A G 11: 6,600,933 S753P probably damaging Het
Ncapd2 A C 6: 125,173,612 M842R probably benign Het
Nkd2 C A 13: 73,821,379 A311S probably benign Het
Nrg1 A G 8: 31,824,580 probably benign Het
Olfr780 A G 10: 129,322,168 I182V probably benign Het
Pde6h A G 6: 136,959,282 S8G probably null Het
Pik3c2b A G 1: 133,079,745 K616E probably benign Het
Pnpt1 A T 11: 29,132,845 R54S probably benign Het
Rttn A G 18: 88,975,751 D184G probably damaging Het
Skint5 T A 4: 113,717,087 I756F unknown Het
Slc24a2 T C 4: 87,226,906 T304A probably benign Het
Spata5 T C 3: 37,464,651 I778T probably damaging Het
Stk3 A T 15: 35,099,426 probably benign Het
Trim69 A G 2: 122,167,647 I33M probably benign Het
Ube2q2 A T 9: 55,195,039 probably benign Het
Vmn1r67 T A 7: 10,447,467 N158K probably benign Het
Wipi2 G A 5: 142,663,102 E252K probably benign Het
Other mutations in Olfr1310
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01947:Olfr1310 APN 2 112009016 missense possibly damaging 0.86
IGL02700:Olfr1310 APN 2 112008691 missense probably benign 0.04
IGL03008:Olfr1310 APN 2 112008523 missense possibly damaging 0.95
R0025:Olfr1310 UTSW 2 112009020 missense probably damaging 0.98
R1624:Olfr1310 UTSW 2 112008532 missense probably damaging 1.00
R1851:Olfr1310 UTSW 2 112008691 missense probably benign 0.04
R3872:Olfr1310 UTSW 2 112008323 missense possibly damaging 0.95
R3873:Olfr1310 UTSW 2 112008323 missense possibly damaging 0.95
R3874:Olfr1310 UTSW 2 112008323 missense possibly damaging 0.95
R4651:Olfr1310 UTSW 2 112008250 missense probably damaging 1.00
R4652:Olfr1310 UTSW 2 112008250 missense probably damaging 1.00
R4834:Olfr1310 UTSW 2 112008931 missense probably damaging 1.00
R5076:Olfr1310 UTSW 2 112008592 missense probably damaging 0.99
R7262:Olfr1310 UTSW 2 112008557 missense probably damaging 1.00
R7339:Olfr1310 UTSW 2 112008475 missense probably damaging 1.00
R7657:Olfr1310 UTSW 2 112008748 missense probably benign 0.02
X0027:Olfr1310 UTSW 2 112008824 missense probably damaging 1.00
Posted On2016-08-02