Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03122:Tas2r103'

410000

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r103

Ensembl Gene

ENSMUSG00000030196

Gene Name

taste receptor, type 2, member 103

Synonyms

mt2r63, T2R3, Tas2r10, EG667992, mGR03, TRB2, Tas2r3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL03122

Quality Score

Status

Chromosome

Chromosomal Location

133036163-133037101 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 133036909 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 65 (S65P)

Ref Sequence

ENSEMBL: ENSMUSP00000032317 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032317]

AlphaFold

Q9JKA3

Predicted Effect

probably damaging
Transcript: ENSMUST00000032317
AA Change: S65P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000032317
Gene: ENSMUSG00000030196
AA Change: S65P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	5	301	1.5e-79	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5430419D17Rik	A	G	7: 131,196,514	Q84R	possibly damaging	Het
Adgrg7	G	A	16: 56,770,362		probably benign	Het
Afap1l1	T	C	18: 61,733,831	D719G	probably benign	Het
Amph	C	T	13: 19,102,943	T274M	probably damaging	Het
Atp2c2	T	A	8: 119,742,675	D396E	possibly damaging	Het
Atpaf1	T	C	4: 115,791,278	I164T	probably damaging	Het
Avpr1b	C	A	1: 131,600,519	P260Q	probably damaging	Het
Cacna1a	T	C	8: 84,462,676		probably benign	Het
Cald1	A	G	6: 34,765,028	I449V	probably damaging	Het
Ccdc24	A	G	4: 117,871,745		probably null	Het
Cenpk	C	A	13: 104,242,377	Q134K	probably damaging	Het
Clasp1	A	G	1: 118,510,277	N373D	probably damaging	Het
Col7a1	T	A	9: 108,961,683	S1042T	unknown	Het
Cry2	G	A	2: 92,413,295	R439C	probably damaging	Het
Dip2a	G	T	10: 76,275,046	D1138E	probably benign	Het
Dlgap3	T	C	4: 127,195,225	S205P	possibly damaging	Het
Echdc2	T	A	4: 108,165,580	S18T	probably benign	Het
Efcab2	T	A	1: 178,437,477	V36E	probably damaging	Het
Galk1	A	T	11: 116,010,239		probably null	Het
Hoxc11	A	T	15: 102,954,955	N144Y	probably damaging	Het
Ift140	T	A	17: 25,086,910	C824S	probably damaging	Het
Inf2	A	G	12: 112,604,229	S401G	probably benign	Het
Kcnn1	T	G	8: 70,855,080	D106A	probably damaging	Het
Lama4	A	G	10: 39,067,963	N754S	probably benign	Het
March6	A	G	15: 31,478,293		probably null	Het
Nlrp1b	A	C	11: 71,181,833	C395G	probably benign	Het
Olfr136	T	C	17: 38,335,301	V48A	probably benign	Het
Olfr1500	A	G	19: 13,827,650	S249P	possibly damaging	Het
Olfr194	T	C	16: 59,119,438	M211V	probably benign	Het
Olfr730	A	T	14: 50,187,004	M71K	probably damaging	Het
Scel	A	G	14: 103,599,406	R477G	possibly damaging	Het
Sdk2	A	G	11: 113,842,068	S984P	probably damaging	Het
Slc4a7	C	T	14: 14,782,040		probably benign	Het
Tnip2	T	C	5: 34,503,751	E119G	possibly damaging	Het
Zgrf1	T	A	3: 127,588,133	L310M	possibly damaging	Het

Other mutations in Tas2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02230:Tas2r103	APN	6	133037056	missense	possibly damaging	0.86
IGL02332:Tas2r103	APN	6	133036512	missense	probably benign	0.21
IGL03167:Tas2r103	APN	6	133036660	missense	probably damaging	0.98
R0380:Tas2r103	UTSW	6	133036203	missense	probably damaging	1.00
R0671:Tas2r103	UTSW	6	133036350	missense	probably benign	0.01
R1700:Tas2r103	UTSW	6	133036811	missense	probably damaging	1.00
R2098:Tas2r103	UTSW	6	133036597	missense	probably benign
R3977:Tas2r103	UTSW	6	133036317	missense	probably benign	0.16
R3979:Tas2r103	UTSW	6	133036317	missense	probably benign	0.16
R3980:Tas2r103	UTSW	6	133036317	missense	probably benign	0.16
R4924:Tas2r103	UTSW	6	133036198	missense	probably benign	0.02
R5779:Tas2r103	UTSW	6	133036945	missense	probably benign	0.02
R5839:Tas2r103	UTSW	6	133036816	missense	probably benign	0.06
R6265:Tas2r103	UTSW	6	133036531	missense	probably damaging	1.00
R7768:Tas2r103	UTSW	6	133036849	missense	probably benign	0.06
R8851:Tas2r103	UTSW	6	133036933	missense
R9435:Tas2r103	UTSW	6	133036723	nonsense	probably null

Posted On

2016-08-02