Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03122:Tas2r103'

410000

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r103

Ensembl Gene

ENSMUSG00000030196

Gene Name

taste receptor, type 2, member 103

Synonyms

TRB2, T2R3, mGR03, mt2r63, Tas2r10, Tas2r3, EG667992

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL03122

Quality Score

Status

Chromosome

Chromosomal Location

133013126-133014064 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 133013872 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 65 (S65P)

Ref Sequence

ENSEMBL: ENSMUSP00000032317 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032317]

AlphaFold

Q9JKA3

Predicted Effect

probably damaging
Transcript: ENSMUST00000032317
AA Change: S65P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000032317
Gene: ENSMUSG00000030196
AA Change: S65P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	5	301	1.5e-79	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrg7	G	A	16: 56,590,725 (GRCm39)		probably benign	Het
Afap1l1	T	C	18: 61,866,902 (GRCm39)	D719G	probably benign	Het
Amph	C	T	13: 19,287,113 (GRCm39)	T274M	probably damaging	Het
Atp2c2	T	A	8: 120,469,414 (GRCm39)	D396E	possibly damaging	Het
Atpaf1	T	C	4: 115,648,475 (GRCm39)	I164T	probably damaging	Het
Avpr1b	C	A	1: 131,528,257 (GRCm39)	P260Q	probably damaging	Het
Cacna1a	T	C	8: 85,189,305 (GRCm39)		probably benign	Het
Cald1	A	G	6: 34,741,963 (GRCm39)	I449V	probably damaging	Het
Ccdc24	A	G	4: 117,728,942 (GRCm39)		probably null	Het
Cdcp3	A	G	7: 130,798,243 (GRCm39)	Q84R	possibly damaging	Het
Cenpk	C	A	13: 104,378,885 (GRCm39)	Q134K	probably damaging	Het
Clasp1	A	G	1: 118,438,007 (GRCm39)	N373D	probably damaging	Het
Col7a1	T	A	9: 108,790,751 (GRCm39)	S1042T	unknown	Het
Cry2	G	A	2: 92,243,640 (GRCm39)	R439C	probably damaging	Het
Dip2a	G	T	10: 76,110,880 (GRCm39)	D1138E	probably benign	Het
Dlgap3	T	C	4: 127,089,018 (GRCm39)	S205P	possibly damaging	Het
Echdc2	T	A	4: 108,022,777 (GRCm39)	S18T	probably benign	Het
Efcab2	T	A	1: 178,265,042 (GRCm39)	V36E	probably damaging	Het
Galk1	A	T	11: 115,901,065 (GRCm39)		probably null	Het
Hoxc11	A	T	15: 102,863,390 (GRCm39)	N144Y	probably damaging	Het
Ift140	T	A	17: 25,305,884 (GRCm39)	C824S	probably damaging	Het
Inf2	A	G	12: 112,570,663 (GRCm39)	S401G	probably benign	Het
Kcnn1	T	G	8: 71,307,724 (GRCm39)	D106A	probably damaging	Het
Lama4	A	G	10: 38,943,959 (GRCm39)	N754S	probably benign	Het
Marchf6	A	G	15: 31,478,439 (GRCm39)		probably null	Het
Nlrp1b	A	C	11: 71,072,659 (GRCm39)	C395G	probably benign	Het
Or2n1d	T	C	17: 38,646,192 (GRCm39)	V48A	probably benign	Het
Or4k2	A	T	14: 50,424,461 (GRCm39)	M71K	probably damaging	Het
Or5ac15	T	C	16: 58,939,801 (GRCm39)	M211V	probably benign	Het
Or9q1	A	G	19: 13,805,014 (GRCm39)	S249P	possibly damaging	Het
Scel	A	G	14: 103,836,842 (GRCm39)	R477G	possibly damaging	Het
Sdk2	A	G	11: 113,732,894 (GRCm39)	S984P	probably damaging	Het
Slc4a7	C	T	14: 14,782,040 (GRCm38)		probably benign	Het
Tnip2	T	C	5: 34,661,095 (GRCm39)	E119G	possibly damaging	Het
Zgrf1	T	A	3: 127,381,782 (GRCm39)	L310M	possibly damaging	Het

Other mutations in Tas2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02230:Tas2r103	APN	6	133,014,019 (GRCm39)	missense	possibly damaging	0.86
IGL02332:Tas2r103	APN	6	133,013,475 (GRCm39)	missense	probably benign	0.21
IGL03167:Tas2r103	APN	6	133,013,623 (GRCm39)	missense	probably damaging	0.98
R0380:Tas2r103	UTSW	6	133,013,166 (GRCm39)	missense	probably damaging	1.00
R0671:Tas2r103	UTSW	6	133,013,313 (GRCm39)	missense	probably benign	0.01
R1700:Tas2r103	UTSW	6	133,013,774 (GRCm39)	missense	probably damaging	1.00
R2098:Tas2r103	UTSW	6	133,013,560 (GRCm39)	missense	probably benign
R3977:Tas2r103	UTSW	6	133,013,280 (GRCm39)	missense	probably benign	0.16
R3979:Tas2r103	UTSW	6	133,013,280 (GRCm39)	missense	probably benign	0.16
R3980:Tas2r103	UTSW	6	133,013,280 (GRCm39)	missense	probably benign	0.16
R4924:Tas2r103	UTSW	6	133,013,161 (GRCm39)	missense	probably benign	0.02
R5779:Tas2r103	UTSW	6	133,013,908 (GRCm39)	missense	probably benign	0.02
R5839:Tas2r103	UTSW	6	133,013,779 (GRCm39)	missense	probably benign	0.06
R6265:Tas2r103	UTSW	6	133,013,494 (GRCm39)	missense	probably damaging	1.00
R7768:Tas2r103	UTSW	6	133,013,812 (GRCm39)	missense	probably benign	0.06
R8851:Tas2r103	UTSW	6	133,013,896 (GRCm39)	missense
R9435:Tas2r103	UTSW	6	133,013,686 (GRCm39)	nonsense	probably null

Posted On

2016-08-02