Incidental Mutation 'IGL03124:Trav17'
ID410078
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trav17
Ensembl Gene ENSMUSG00000096397
Gene NameT cell receptor alpha variable 17
SynonymsOTTMUSG00000015028
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.173) question?
Stock #IGL03124
Quality Score
Status
Chromosome14
Chromosomal Location53806525-53807113 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 53806649 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 4 (V4A)
Ref Sequence ENSEMBL: ENSMUSP00000140087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103672] [ENSMUST00000186545]
Predicted Effect probably benign
Transcript: ENSMUST00000103672
AA Change: V4A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000100449
Gene: ENSMUSG00000096397
AA Change: V4A

DomainStartEndE-ValueType
Pfam:V-set 20 113 2.2e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000186545
AA Change: V4A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000140087
Gene: ENSMUSG00000096397
AA Change: V4A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG_like 36 111 4.9e-6 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110017D15Rik T C 4: 41,507,287 N170D possibly damaging Het
1700018B08Rik C A 8: 121,541,710 probably benign Het
4931414P19Rik A G 14: 54,595,139 V193A probably benign Het
Acap3 T C 4: 155,905,033 S645P probably benign Het
Alms1 A G 6: 85,678,419 I3316V probably benign Het
Apc T G 18: 34,299,985 H424Q probably damaging Het
BC003331 A G 1: 150,386,425 V88A probably benign Het
Camsap2 A T 1: 136,274,799 probably null Het
Car13 C T 3: 14,656,940 P182L possibly damaging Het
Ccdc87 T G 19: 4,841,054 S525A probably damaging Het
Ces1f T C 8: 93,275,384 N39D probably benign Het
Cyp2j13 C A 4: 96,061,922 A281S possibly damaging Het
Cyp4f15 G A 17: 32,685,812 probably null Het
Fam208b A T 13: 3,574,704 Y1749N probably benign Het
Fat4 C A 3: 38,981,552 R3118S possibly damaging Het
Glg1 C T 8: 111,200,171 V171M probably damaging Het
Hivep1 G T 13: 42,158,904 G1540V possibly damaging Het
Ighm T C 12: 113,421,638 D234G unknown Het
Igsf10 T C 3: 59,319,665 T2196A probably benign Het
Kctd19 T A 8: 105,387,070 Q657L possibly damaging Het
Klhl40 T A 9: 121,780,685 I512N probably damaging Het
Lima1 A T 15: 99,796,734 probably benign Het
Map2k4 A C 11: 65,690,791 I365S probably damaging Het
Mast4 T A 13: 102,738,245 K1346N probably damaging Het
Met T A 6: 17,492,078 F280I probably benign Het
Ncapg A G 5: 45,671,209 T101A probably benign Het
Nup214 T C 2: 31,996,440 F605L probably benign Het
Olfr291 T A 7: 84,856,723 M118K probably damaging Het
Olfr639 G T 7: 104,011,794 Q303K probably benign Het
Olfr873 T A 9: 20,301,163 M322K probably benign Het
Pck2 C T 14: 55,545,333 T373I probably damaging Het
Pcna C T 2: 132,251,753 E109K probably benign Het
Pecr A C 1: 72,277,340 S69A probably benign Het
Pitpnb A G 5: 111,330,830 E6G possibly damaging Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Plbd2 A T 5: 120,493,077 F212I possibly damaging Het
Rfk T A 19: 17,398,595 H84Q possibly damaging Het
Scp2 T A 4: 108,063,906 I36F probably damaging Het
Slc9a4 A G 1: 40,580,735 T74A probably damaging Het
St6galnac1 G A 11: 116,775,299 A35V probably benign Het
Tmem8 G A 17: 26,116,834 R65Q probably damaging Het
Vmn1r57 A T 7: 5,221,022 H182L possibly damaging Het
Vwa8 A T 14: 79,058,815 probably benign Het
Zgpat A G 2: 181,366,180 Y170C probably benign Het
Other mutations in Trav17
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2867:Trav17 UTSW 14 53806926 missense probably benign 0.03
R2867:Trav17 UTSW 14 53806926 missense probably benign 0.03
R2903:Trav17 UTSW 14 53806666 missense probably benign 0.17
R4776:Trav17 UTSW 14 53806640 start codon destroyed probably null 1.00
R7308:Trav17 UTSW 14 53806979 missense probably benign 0.38
R7451:Trav17 UTSW 14 53806639 start codon destroyed probably damaging 0.98
R7588:Trav17 UTSW 14 53806845 missense probably benign 0.00
Posted On2016-08-02