Incidental Mutation 'IGL03126:Or3a1b'
ID 410143
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or3a1b
Ensembl Gene ENSMUSG00000070380
Gene Name olfactory receptor family 3 subfamily A member 1B
Synonyms GA_x6K02T2P1NL-4278037-4278984, Olfr401, MOR255-6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL03126
Quality Score
Status
Chromosome 11
Chromosomal Location 74012117-74013064 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 74012610 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 165 (A165V)
Ref Sequence ENSEMBL: ENSMUSP00000149542 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079827] [ENSMUST00000213754]
AlphaFold Q8VFX6
Predicted Effect probably benign
Transcript: ENSMUST00000079827
AA Change: A165V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000078756
Gene: ENSMUSG00000070380
AA Change: A165V

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 9.4e-51 PFAM
Pfam:7tm_1 44 293 2.2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213754
AA Change: A165V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik A G 13: 119,617,563 (GRCm39) N562S probably benign Het
Abi1 A G 2: 22,843,479 (GRCm39) V316A probably benign Het
Acsm1 A T 7: 119,232,403 (GRCm39) Q100L possibly damaging Het
Akr1c21 T C 13: 4,627,457 (GRCm39) Y184H possibly damaging Het
Anks3 T C 16: 4,775,891 (GRCm39) T104A probably damaging Het
Bcl2l2 A G 14: 55,122,224 (GRCm39) Y129C probably damaging Het
Cenpf T A 1: 189,391,207 (GRCm39) K875I probably damaging Het
Cntnap1 T C 11: 101,067,127 (GRCm39) V15A probably benign Het
Dnaaf9 A T 2: 130,633,915 (GRCm39) probably null Het
Elmo3 C A 8: 106,033,013 (GRCm39) R66S probably damaging Het
Elp1 A G 4: 56,779,717 (GRCm39) S565P probably benign Het
Epn1 C A 7: 5,098,684 (GRCm39) A370E probably benign Het
Esrrg T C 1: 187,730,184 (GRCm39) probably benign Het
Fgd5 T G 6: 92,042,145 (GRCm39) L1034R probably damaging Het
Fpgs A G 2: 32,573,135 (GRCm39) V567A possibly damaging Het
Fut2 C T 7: 45,300,193 (GRCm39) G193E possibly damaging Het
H3c3 T C 13: 23,929,425 (GRCm39) K19R possibly damaging Het
Hsd17b14 T C 7: 45,205,503 (GRCm39) F38S possibly damaging Het
Larp1 T C 11: 57,941,703 (GRCm39) V712A possibly damaging Het
Mep1b T C 18: 21,221,617 (GRCm39) F189S probably damaging Het
Mill1 T C 7: 17,989,832 (GRCm39) V38A probably benign Het
Niban2 C T 2: 32,766,398 (GRCm39) R13W possibly damaging Het
Npy4r T C 14: 33,868,290 (GRCm39) I333V probably benign Het
Numa1 G T 7: 101,649,874 (GRCm39) E1202* probably null Het
Or6k6 A G 1: 173,945,276 (GRCm39) I102T probably benign Het
Oxr1 A T 15: 41,683,645 (GRCm39) Q356L possibly damaging Het
Prdx2 T C 8: 85,698,198 (GRCm39) F130L probably damaging Het
Rasa1 A T 13: 85,404,515 (GRCm39) S248R possibly damaging Het
Rgs19 A G 2: 181,333,114 (GRCm39) S49P probably benign Het
Rinl A G 7: 28,495,075 (GRCm39) probably benign Het
Serpinb11 T C 1: 107,307,654 (GRCm39) F362L probably damaging Het
Slamf8 T C 1: 172,411,736 (GRCm39) H253R possibly damaging Het
Tet3 C A 6: 83,353,769 (GRCm39) R829L probably damaging Het
Trappc8 A G 18: 20,996,652 (GRCm39) L420P probably damaging Het
Ube2u A T 4: 100,407,199 (GRCm39) *353Y probably null Het
Wbp1l A C 19: 46,632,838 (GRCm39) D46A probably damaging Het
Zbtb21 A G 16: 97,752,945 (GRCm39) V474A probably damaging Het
Other mutations in Or3a1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Or3a1b APN 11 74,012,705 (GRCm39) missense probably benign 0.00
IGL01303:Or3a1b APN 11 74,012,160 (GRCm39) missense probably damaging 1.00
IGL01397:Or3a1b APN 11 74,012,590 (GRCm39) missense probably damaging 0.97
IGL02101:Or3a1b APN 11 74,012,571 (GRCm39) nonsense probably null
IGL02121:Or3a1b APN 11 74,012,113 (GRCm39) splice site probably benign
IGL02347:Or3a1b APN 11 74,012,397 (GRCm39) missense probably benign 0.03
IGL03113:Or3a1b APN 11 74,012,529 (GRCm39) missense probably benign 0.13
IGL03302:Or3a1b APN 11 74,012,459 (GRCm39) missense possibly damaging 0.60
R0549:Or3a1b UTSW 11 74,012,301 (GRCm39) missense probably damaging 1.00
R1180:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R1350:Or3a1b UTSW 11 74,013,039 (GRCm39) missense possibly damaging 0.96
R1800:Or3a1b UTSW 11 74,012,234 (GRCm39) missense probably benign 0.00
R1808:Or3a1b UTSW 11 74,012,257 (GRCm39) missense probably damaging 0.96
R1962:Or3a1b UTSW 11 74,012,650 (GRCm39) missense probably benign 0.02
R1998:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R1999:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R2000:Or3a1b UTSW 11 74,012,406 (GRCm39) missense probably benign 0.28
R2859:Or3a1b UTSW 11 74,012,808 (GRCm39) missense probably damaging 1.00
R4914:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4915:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4916:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R4918:Or3a1b UTSW 11 74,012,705 (GRCm39) missense probably benign 0.00
R5292:Or3a1b UTSW 11 74,012,877 (GRCm39) missense probably damaging 0.99
R5522:Or3a1b UTSW 11 74,012,484 (GRCm39) missense probably damaging 1.00
R5761:Or3a1b UTSW 11 74,012,335 (GRCm39) missense probably damaging 0.97
R6318:Or3a1b UTSW 11 74,012,547 (GRCm39) missense possibly damaging 0.82
R6608:Or3a1b UTSW 11 74,012,454 (GRCm39) missense probably benign 0.00
R6737:Or3a1b UTSW 11 74,012,732 (GRCm39) missense probably benign
R6790:Or3a1b UTSW 11 74,012,427 (GRCm39) missense probably damaging 1.00
R7243:Or3a1b UTSW 11 74,012,559 (GRCm39) missense probably damaging 0.97
R7423:Or3a1b UTSW 11 74,012,811 (GRCm39) missense probably benign 0.01
R7517:Or3a1b UTSW 11 74,012,335 (GRCm39) missense probably damaging 0.97
R7833:Or3a1b UTSW 11 74,012,663 (GRCm39) missense probably damaging 1.00
R8241:Or3a1b UTSW 11 74,013,035 (GRCm39) missense probably benign 0.03
R8423:Or3a1b UTSW 11 74,012,492 (GRCm39) missense probably benign 0.06
R8937:Or3a1b UTSW 11 74,012,874 (GRCm39) missense probably benign 0.03
R9145:Or3a1b UTSW 11 74,012,526 (GRCm39) missense probably benign 0.01
R9725:Or3a1b UTSW 11 74,012,612 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02