Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03126:Npy4r'

410156

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Npy4r

Ensembl Gene

ENSMUSG00000048337

Gene Name

neuropeptide Y receptor Y4

Synonyms

NYYR-D, Ppyr1, Y4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL03126

Quality Score

Status

Chromosome

Chromosomal Location

33867603-33874376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 33868290 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 333 (I333V)

Ref Sequence

ENSEMBL: ENSMUSP00000056576 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052164]

AlphaFold

Q61041

Predicted Effect

probably benign
Transcript: ENSMUST00000052164
AA Change: I333V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000056576
Gene: ENSMUSG00000048337
AA Change: I333V

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	52	337	2.5e-6	PFAM
Pfam:7tm_1	58	322	1.6e-48	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele exhibit decreased weight, increased drinking behavior, decreased food intake, aggression towards other mice, decreased white adipose tissue, and accelerated lobuloalveolar development during pregnancy. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	A	G	13: 119,617,563 (GRCm39)	N562S	probably benign	Het
Abi1	A	G	2: 22,843,479 (GRCm39)	V316A	probably benign	Het
Acsm1	A	T	7: 119,232,403 (GRCm39)	Q100L	possibly damaging	Het
Akr1c21	T	C	13: 4,627,457 (GRCm39)	Y184H	possibly damaging	Het
Anks3	T	C	16: 4,775,891 (GRCm39)	T104A	probably damaging	Het
Bcl2l2	A	G	14: 55,122,224 (GRCm39)	Y129C	probably damaging	Het
Cenpf	T	A	1: 189,391,207 (GRCm39)	K875I	probably damaging	Het
Cntnap1	T	C	11: 101,067,127 (GRCm39)	V15A	probably benign	Het
Dnaaf9	A	T	2: 130,633,915 (GRCm39)		probably null	Het
Elmo3	C	A	8: 106,033,013 (GRCm39)	R66S	probably damaging	Het
Elp1	A	G	4: 56,779,717 (GRCm39)	S565P	probably benign	Het
Epn1	C	A	7: 5,098,684 (GRCm39)	A370E	probably benign	Het
Esrrg	T	C	1: 187,730,184 (GRCm39)		probably benign	Het
Fgd5	T	G	6: 92,042,145 (GRCm39)	L1034R	probably damaging	Het
Fpgs	A	G	2: 32,573,135 (GRCm39)	V567A	possibly damaging	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
H3c3	T	C	13: 23,929,425 (GRCm39)	K19R	possibly damaging	Het
Hsd17b14	T	C	7: 45,205,503 (GRCm39)	F38S	possibly damaging	Het
Larp1	T	C	11: 57,941,703 (GRCm39)	V712A	possibly damaging	Het
Mep1b	T	C	18: 21,221,617 (GRCm39)	F189S	probably damaging	Het
Mill1	T	C	7: 17,989,832 (GRCm39)	V38A	probably benign	Het
Niban2	C	T	2: 32,766,398 (GRCm39)	R13W	possibly damaging	Het
Numa1	G	T	7: 101,649,874 (GRCm39)	E1202*	probably null	Het
Or3a1b	C	T	11: 74,012,610 (GRCm39)	A165V	probably benign	Het
Or6k6	A	G	1: 173,945,276 (GRCm39)	I102T	probably benign	Het
Oxr1	A	T	15: 41,683,645 (GRCm39)	Q356L	possibly damaging	Het
Prdx2	T	C	8: 85,698,198 (GRCm39)	F130L	probably damaging	Het
Rasa1	A	T	13: 85,404,515 (GRCm39)	S248R	possibly damaging	Het
Rgs19	A	G	2: 181,333,114 (GRCm39)	S49P	probably benign	Het
Rinl	A	G	7: 28,495,075 (GRCm39)		probably benign	Het
Serpinb11	T	C	1: 107,307,654 (GRCm39)	F362L	probably damaging	Het
Slamf8	T	C	1: 172,411,736 (GRCm39)	H253R	possibly damaging	Het
Tet3	C	A	6: 83,353,769 (GRCm39)	R829L	probably damaging	Het
Trappc8	A	G	18: 20,996,652 (GRCm39)	L420P	probably damaging	Het
Ube2u	A	T	4: 100,407,199 (GRCm39)	*353Y	probably null	Het
Wbp1l	A	C	19: 46,632,838 (GRCm39)	D46A	probably damaging	Het
Zbtb21	A	G	16: 97,752,945 (GRCm39)	V474A	probably damaging	Het

Other mutations in Npy4r

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01303:Npy4r	APN	14	33,868,614 (GRCm39)	missense	possibly damaging	0.56
IGL01449:Npy4r	APN	14	33,868,322 (GRCm39)	missense	probably damaging	1.00
IGL01982:Npy4r	APN	14	33,869,282 (GRCm39)	missense	possibly damaging	0.73
R0011:Npy4r	UTSW	14	33,868,680 (GRCm39)	missense	probably damaging	0.99
R0011:Npy4r	UTSW	14	33,868,680 (GRCm39)	missense	probably damaging	0.99
R0579:Npy4r	UTSW	14	33,868,640 (GRCm39)	missense	probably benign	0.16
R2012:Npy4r	UTSW	14	33,869,154 (GRCm39)	missense	possibly damaging	0.58
R3735:Npy4r	UTSW	14	33,869,226 (GRCm39)	missense	probably benign	0.00
R4093:Npy4r	UTSW	14	33,869,098 (GRCm39)	missense	probably benign	0.21
R4650:Npy4r	UTSW	14	33,868,181 (GRCm39)	missense	possibly damaging	0.55
R4861:Npy4r	UTSW	14	33,868,840 (GRCm39)	nonsense	probably null
R4861:Npy4r	UTSW	14	33,868,840 (GRCm39)	nonsense	probably null
R4953:Npy4r	UTSW	14	33,868,437 (GRCm39)	missense	probably damaging	1.00
R4963:Npy4r	UTSW	14	33,868,973 (GRCm39)	missense	probably damaging	1.00
R5387:Npy4r	UTSW	14	33,868,940 (GRCm39)	missense	probably benign	0.21
R5973:Npy4r	UTSW	14	33,868,664 (GRCm39)	missense	probably benign	0.00
R6948:Npy4r	UTSW	14	33,868,731 (GRCm39)	missense	probably benign
R7251:Npy4r	UTSW	14	33,868,872 (GRCm39)	missense	probably damaging	1.00
R8081:Npy4r	UTSW	14	33,868,524 (GRCm39)	missense	probably damaging	0.99
R9051:Npy4r	UTSW	14	33,869,083 (GRCm39)	missense	possibly damaging	0.94
R9654:Npy4r	UTSW	14	33,869,081 (GRCm39)	missense	probably damaging	0.98

Posted On

2016-08-02