Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03129:Zfp507'

410235

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp507

Ensembl Gene

ENSMUSG00000044452

Gene Name

zinc finger protein 507

Synonyms

1810022O10Rik, A230056M16Rik

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.312) question?

Stock #

IGL03129

Quality Score

Status

Chromosome

Chromosomal Location

35772343-35803003 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 35794206 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 471 (R471G)

Ref Sequence

ENSEMBL: ENSMUSP00000058609 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061586] [ENSMUST00000187282] [ENSMUST00000205670] [ENSMUST00000206615]

Predicted Effect

probably damaging
Transcript: ENSMUST00000061586
AA Change: R471G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000058609
Gene: ENSMUSG00000044452
AA Change: R471G

Domain	Start	End	E-Value	Type
ZnF_C2H2	122	144	1.56e-2	SMART
ZnF_C2H2	152	175	2.49e-1	SMART
low complexity region	178	192	N/A	INTRINSIC
ZnF_C2H2	237	259	8.52e0	SMART
ZnF_C2H2	630	652	2.75e-3	SMART
ZnF_C2H2	658	680	1.26e-2	SMART
ZnF_C2H2	686	709	5.42e-2	SMART
ZnF_C2H2	746	768	4.79e-3	SMART
ZnF_C2H2	774	796	1.45e-2	SMART
ZnF_C2H2	899	921	3.83e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187282

SMART Domains

Protein: ENSMUSP00000140940
Gene: ENSMUSG00000044452

Domain	Start	End	E-Value	Type
ZnF_C2H2	107	129	1.6e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000205670

Predicted Effect

probably benign
Transcript: ENSMUST00000206615

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	A	G	5: 99,229,379	V403A	probably damaging	Het
Adpgk	T	C	9: 59,313,805	L298P	probably damaging	Het
Akap6	A	T	12: 53,140,306	D1501V	probably damaging	Het
Ank2	C	A	3: 126,955,870	E503D	probably damaging	Het
Ankhd1	T	A	18: 36,658,008	Y2478*	probably null	Het
Col6a3	A	G	1: 90,821,862	Y417H	probably damaging	Het
Csmd1	A	G	8: 15,961,521	F2511L	probably damaging	Het
Dzip3	T	C	16: 48,942,083	M602V	possibly damaging	Het
Efna2	G	A	10: 80,188,512		probably null	Het
Fzd8	T	C	18: 9,214,270	S451P	probably damaging	Het
Galntl6	A	T	8: 58,427,716	D134E	probably damaging	Het
Gm10334	T	C	6: 41,443,498	N98S	probably benign	Het
Grid2	T	C	6: 64,063,904	S277P	probably damaging	Het
Lcn2	A	G	2: 32,387,704	V91A	possibly damaging	Het
Lrp1b	G	A	2: 41,312,466		probably benign	Het
Lrrc7	T	A	3: 158,161,059	Y1015F	probably benign	Het
Mdn1	T	A	4: 32,729,994	C2779S	possibly damaging	Het
Nlrp10	A	T	7: 108,924,911	F454Y	probably damaging	Het
Obox5	T	A	7: 15,758,759	L213Q	probably damaging	Het
Olfr97	T	A	17: 37,232,196	Y58F	probably damaging	Het
Piezo2	T	C	18: 63,114,972	M486V	probably benign	Het
Plcg1	A	C	2: 160,774,526		probably null	Het
Polr1b	G	A	2: 129,115,707	V561I	probably benign	Het
Polr3c	A	T	3: 96,719,454		probably benign	Het
Prkg1	T	A	19: 30,585,281	K523*	probably null	Het
Sema3b	T	A	9: 107,599,796		probably benign	Het
Sp9	A	G	2: 73,273,521	T140A	probably benign	Het

Other mutations in Zfp507

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Zfp507	APN	7	35794712	missense	possibly damaging	0.93
IGL00835:Zfp507	APN	7	35776038	missense	probably damaging	1.00
IGL01083:Zfp507	APN	7	35794038	missense	probably benign	0.00
IGL01359:Zfp507	APN	7	35794502	missense	probably damaging	1.00
IGL01418:Zfp507	APN	7	35793812	intron	probably null
IGL02122:Zfp507	APN	7	35776095	missense	probably damaging	1.00
IGL02506:Zfp507	APN	7	35776466	missense	probably damaging	1.00
IGL02601:Zfp507	APN	7	35791711	missense	probably damaging	1.00
IGL02643:Zfp507	APN	7	35795231	missense	probably damaging	0.99
R0400:Zfp507	UTSW	7	35791746	missense	probably damaging	1.00
R0812:Zfp507	UTSW	7	35802623	intron	probably benign
R1183:Zfp507	UTSW	7	35794890	missense	probably damaging	0.99
R1381:Zfp507	UTSW	7	35776010	missense	possibly damaging	0.91
R1542:Zfp507	UTSW	7	35794801	missense	possibly damaging	0.71
R1626:Zfp507	UTSW	7	35795433	missense	probably damaging	1.00
R1759:Zfp507	UTSW	7	35775978	missense	probably damaging	0.99
R1843:Zfp507	UTSW	7	35793725	missense	probably damaging	0.97
R1852:Zfp507	UTSW	7	35787751	missense	probably damaging	1.00
R1893:Zfp507	UTSW	7	35802627	intron	probably benign
R1923:Zfp507	UTSW	7	35793725	missense	probably damaging	0.97
R1925:Zfp507	UTSW	7	35793725	missense	probably damaging	0.97
R1927:Zfp507	UTSW	7	35793725	missense	probably damaging	0.97
R2139:Zfp507	UTSW	7	35793723	missense	probably damaging	1.00
R2191:Zfp507	UTSW	7	35794843	missense	probably damaging	1.00
R2431:Zfp507	UTSW	7	35795402	missense	probably benign	0.08
R2921:Zfp507	UTSW	7	35794799	missense	probably damaging	1.00
R2922:Zfp507	UTSW	7	35794799	missense	probably damaging	1.00
R3436:Zfp507	UTSW	7	35787770	missense	probably damaging	1.00
R4483:Zfp507	UTSW	7	35787716	critical splice donor site	probably null
R4751:Zfp507	UTSW	7	35794382	missense	probably damaging	0.99
R4852:Zfp507	UTSW	7	35794055	missense	probably benign	0.01
R5298:Zfp507	UTSW	7	35775996	missense	probably damaging	0.99
R5602:Zfp507	UTSW	7	35776238	nonsense	probably null
R5707:Zfp507	UTSW	7	35794163	missense	probably damaging	1.00
R5785:Zfp507	UTSW	7	35787742	missense	probably benign	0.20
R6140:Zfp507	UTSW	7	35794188	missense	probably damaging	1.00
R6674:Zfp507	UTSW	7	35794734	missense	probably damaging	0.98
R6714:Zfp507	UTSW	7	35787727	missense	probably damaging	0.99
R7045:Zfp507	UTSW	7	35795553	missense	possibly damaging	0.56
R7334:Zfp507	UTSW	7	35776080	missense	probably damaging	1.00
R7365:Zfp507	UTSW	7	35776418	missense	unknown
R7569:Zfp507	UTSW	7	35794544	missense	probably damaging	0.99
R7662:Zfp507	UTSW	7	35787804	nonsense	probably null
Z1088:Zfp507	UTSW	7	35794277	missense	possibly damaging	0.88

Posted On

2016-08-02