Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03129:Zfp507'

410235

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp507

Ensembl Gene

ENSMUSG00000044452

Gene Name

zinc finger protein 507

Synonyms

A230056M16Rik, 1810022O10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.190) question?

Stock #

IGL03129

Quality Score

Status

Chromosome

Chromosomal Location

35471768-35502428 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 35493631 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 471 (R471G)

Ref Sequence

ENSEMBL: ENSMUSP00000058609 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061586] [ENSMUST00000187282] [ENSMUST00000205670] [ENSMUST00000206615]

AlphaFold

Q6ZPY5

Predicted Effect

probably damaging
Transcript: ENSMUST00000061586
AA Change: R471G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000058609
Gene: ENSMUSG00000044452
AA Change: R471G

Domain	Start	End	E-Value	Type
ZnF_C2H2	122	144	1.56e-2	SMART
ZnF_C2H2	152	175	2.49e-1	SMART
low complexity region	178	192	N/A	INTRINSIC
ZnF_C2H2	237	259	8.52e0	SMART
ZnF_C2H2	630	652	2.75e-3	SMART
ZnF_C2H2	658	680	1.26e-2	SMART
ZnF_C2H2	686	709	5.42e-2	SMART
ZnF_C2H2	746	768	4.79e-3	SMART
ZnF_C2H2	774	796	1.45e-2	SMART
ZnF_C2H2	899	921	3.83e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187282

SMART Domains

Protein: ENSMUSP00000140940
Gene: ENSMUSG00000044452

Domain	Start	End	E-Value	Type
ZnF_C2H2	107	129	1.6e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000205670

Predicted Effect

probably benign
Transcript: ENSMUST00000206615

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	A	G	5: 99,377,238 (GRCm39)	V403A	probably damaging	Het
Adpgk	T	C	9: 59,221,088 (GRCm39)	L298P	probably damaging	Het
Akap6	A	T	12: 53,187,089 (GRCm39)	D1501V	probably damaging	Het
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Ankhd1	T	A	18: 36,791,061 (GRCm39)	Y2478*	probably null	Het
Col6a3	A	G	1: 90,749,584 (GRCm39)	Y417H	probably damaging	Het
Csmd1	A	G	8: 16,011,521 (GRCm39)	F2511L	probably damaging	Het
Dzip3	T	C	16: 48,762,446 (GRCm39)	M602V	possibly damaging	Het
Efna2	G	A	10: 80,024,346 (GRCm39)		probably null	Het
Fzd8	T	C	18: 9,214,270 (GRCm39)	S451P	probably damaging	Het
Galntl6	A	T	8: 58,880,750 (GRCm39)	D134E	probably damaging	Het
Grid2	T	C	6: 64,040,888 (GRCm39)	S277P	probably damaging	Het
Lcn2	A	G	2: 32,277,716 (GRCm39)	V91A	possibly damaging	Het
Lrp1b	G	A	2: 41,202,478 (GRCm39)		probably benign	Het
Lrrc7	T	A	3: 157,866,696 (GRCm39)	Y1015F	probably benign	Het
Mdn1	T	A	4: 32,729,994 (GRCm39)	C2779S	possibly damaging	Het
Nlrp10	A	T	7: 108,524,118 (GRCm39)	F454Y	probably damaging	Het
Obox5	T	A	7: 15,492,684 (GRCm39)	L213Q	probably damaging	Het
Or1o2	T	A	17: 37,543,087 (GRCm39)	Y58F	probably damaging	Het
Piezo2	T	C	18: 63,248,043 (GRCm39)	M486V	probably benign	Het
Plcg1	A	C	2: 160,616,446 (GRCm39)		probably null	Het
Polr1b	G	A	2: 128,957,627 (GRCm39)	V561I	probably benign	Het
Polr3c	A	T	3: 96,626,770 (GRCm39)		probably benign	Het
Prkg1	T	A	19: 30,562,681 (GRCm39)	K523*	probably null	Het
Prss3l	T	C	6: 41,420,432 (GRCm39)	N98S	probably benign	Het
Sema3b	T	A	9: 107,476,995 (GRCm39)		probably benign	Het
Sp9	A	G	2: 73,103,865 (GRCm39)	T140A	probably benign	Het

Other mutations in Zfp507

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Zfp507	APN	7	35,494,137 (GRCm39)	missense	possibly damaging	0.93
IGL00835:Zfp507	APN	7	35,475,463 (GRCm39)	missense	probably damaging	1.00
IGL01083:Zfp507	APN	7	35,493,463 (GRCm39)	missense	probably benign	0.00
IGL01359:Zfp507	APN	7	35,493,927 (GRCm39)	missense	probably damaging	1.00
IGL01418:Zfp507	APN	7	35,493,237 (GRCm39)	splice site	probably null
IGL02122:Zfp507	APN	7	35,475,520 (GRCm39)	missense	probably damaging	1.00
IGL02506:Zfp507	APN	7	35,475,891 (GRCm39)	missense	probably damaging	1.00
IGL02601:Zfp507	APN	7	35,491,136 (GRCm39)	missense	probably damaging	1.00
IGL02643:Zfp507	APN	7	35,494,656 (GRCm39)	missense	probably damaging	0.99
R0400:Zfp507	UTSW	7	35,491,171 (GRCm39)	missense	probably damaging	1.00
R0812:Zfp507	UTSW	7	35,502,048 (GRCm39)	intron	probably benign
R1183:Zfp507	UTSW	7	35,494,315 (GRCm39)	missense	probably damaging	0.99
R1381:Zfp507	UTSW	7	35,475,435 (GRCm39)	missense	possibly damaging	0.91
R1542:Zfp507	UTSW	7	35,494,226 (GRCm39)	missense	possibly damaging	0.71
R1626:Zfp507	UTSW	7	35,494,858 (GRCm39)	missense	probably damaging	1.00
R1759:Zfp507	UTSW	7	35,475,403 (GRCm39)	missense	probably damaging	0.99
R1843:Zfp507	UTSW	7	35,493,150 (GRCm39)	missense	probably damaging	0.97
R1852:Zfp507	UTSW	7	35,487,176 (GRCm39)	missense	probably damaging	1.00
R1893:Zfp507	UTSW	7	35,502,052 (GRCm39)	intron	probably benign
R1923:Zfp507	UTSW	7	35,493,150 (GRCm39)	missense	probably damaging	0.97
R1925:Zfp507	UTSW	7	35,493,150 (GRCm39)	missense	probably damaging	0.97
R1927:Zfp507	UTSW	7	35,493,150 (GRCm39)	missense	probably damaging	0.97
R2139:Zfp507	UTSW	7	35,493,148 (GRCm39)	missense	probably damaging	1.00
R2191:Zfp507	UTSW	7	35,494,268 (GRCm39)	missense	probably damaging	1.00
R2431:Zfp507	UTSW	7	35,494,827 (GRCm39)	missense	probably benign	0.08
R2921:Zfp507	UTSW	7	35,494,224 (GRCm39)	missense	probably damaging	1.00
R2922:Zfp507	UTSW	7	35,494,224 (GRCm39)	missense	probably damaging	1.00
R3436:Zfp507	UTSW	7	35,487,195 (GRCm39)	missense	probably damaging	1.00
R4483:Zfp507	UTSW	7	35,487,141 (GRCm39)	critical splice donor site	probably null
R4751:Zfp507	UTSW	7	35,493,807 (GRCm39)	missense	probably damaging	0.99
R4852:Zfp507	UTSW	7	35,493,480 (GRCm39)	missense	probably benign	0.01
R5298:Zfp507	UTSW	7	35,475,421 (GRCm39)	missense	probably damaging	0.99
R5602:Zfp507	UTSW	7	35,475,663 (GRCm39)	nonsense	probably null
R5707:Zfp507	UTSW	7	35,493,588 (GRCm39)	missense	probably damaging	1.00
R5785:Zfp507	UTSW	7	35,487,167 (GRCm39)	missense	probably benign	0.20
R6140:Zfp507	UTSW	7	35,493,613 (GRCm39)	missense	probably damaging	1.00
R6674:Zfp507	UTSW	7	35,494,159 (GRCm39)	missense	probably damaging	0.98
R6714:Zfp507	UTSW	7	35,487,152 (GRCm39)	missense	probably damaging	0.99
R7045:Zfp507	UTSW	7	35,494,978 (GRCm39)	missense	possibly damaging	0.56
R7334:Zfp507	UTSW	7	35,475,505 (GRCm39)	missense	probably damaging	1.00
R7365:Zfp507	UTSW	7	35,475,843 (GRCm39)	missense	unknown
R7569:Zfp507	UTSW	7	35,493,969 (GRCm39)	missense	probably damaging	0.99
R7662:Zfp507	UTSW	7	35,487,229 (GRCm39)	nonsense	probably null
R7846:Zfp507	UTSW	7	35,493,963 (GRCm39)	missense	probably damaging	1.00
R9100:Zfp507	UTSW	7	35,494,446 (GRCm39)	missense	probably benign	0.39
R9136:Zfp507	UTSW	7	35,475,883 (GRCm39)	missense	probably damaging	0.96
R9513:Zfp507	UTSW	7	35,475,573 (GRCm39)	missense	probably benign	0.00
Z1088:Zfp507	UTSW	7	35,493,702 (GRCm39)	missense	possibly damaging	0.88

Posted On

2016-08-02