Incidental Mutation 'IGL03130:Tcte1'
ID410290
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tcte1
Ensembl Gene ENSMUSG00000023949
Gene Namet-complex-associated testis expressed 1
SynonymsTcte-1, D17Sil1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03130
Quality Score
Status
Chromosome17
Chromosomal Location45523434-45542679 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 45533296 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 66 (D66G)
Ref Sequence ENSEMBL: ENSMUSP00000109175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113547]
Predicted Effect probably damaging
Transcript: ENSMUST00000113547
AA Change: D66G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000109175
Gene: ENSMUSG00000023949
AA Change: D66G

DomainStartEndE-ValueType
low complexity region 6 17 N/A INTRINSIC
low complexity region 28 47 N/A INTRINSIC
low complexity region 206 222 N/A INTRINSIC
Blast:LRR 235 274 7e-14 BLAST
LRR 304 331 5.02e-6 SMART
LRR 332 358 1.28e-3 SMART
LRR 359 386 5.81e-2 SMART
LRR 387 414 2.05e-2 SMART
LRR 415 442 1.13e-4 SMART
Blast:LRR 443 470 3e-8 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtpbp1 T C 13: 59,474,589 E941G possibly damaging Het
AI314180 A T 4: 58,800,288 C1806S probably benign Het
Akap11 A T 14: 78,510,368 Y1526* probably null Het
Brd1 T C 15: 88,688,374 I1165V probably benign Het
Btbd11 G T 10: 85,388,483 probably null Het
Cdan1 T C 2: 120,727,912 D473G possibly damaging Het
Clstn3 G A 6: 124,459,263 L176F probably damaging Het
Ctif T C 18: 75,521,618 N279S probably benign Het
Dpy19l3 A G 7: 35,752,672 S16P probably benign Het
Fam151b T C 13: 92,450,193 Y244C probably benign Het
Gbf1 T C 19: 46,267,348 M750T possibly damaging Het
Gm11564 T A 11: 99,815,053 T184S unknown Het
Gnptab A G 10: 88,436,371 K958E possibly damaging Het
Hibch T C 1: 52,885,151 S162P possibly damaging Het
Itpr1 T C 6: 108,523,401 S2651P probably benign Het
Lyrm1 A G 7: 119,914,180 D56G probably damaging Het
Manba T C 3: 135,551,159 Y528H probably damaging Het
Npas2 A C 1: 39,313,028 E186D probably damaging Het
Olfr1314 A T 2: 112,091,821 D293E probably benign Het
Olfr371 A T 8: 85,230,629 I45F possibly damaging Het
Olfr867 C A 9: 20,055,372 L30F probably benign Het
Oraov1 A G 7: 144,916,460 E42G probably damaging Het
Pcdhb6 T A 18: 37,335,587 Y520* probably null Het
Plekhm1 C T 11: 103,377,381 R588H probably benign Het
Psg23 A T 7: 18,610,416 H371Q probably benign Het
Ptpn12 T C 5: 21,002,612 probably benign Het
Rela T C 19: 5,639,881 C120R probably damaging Het
Rps6kc1 T A 1: 190,799,811 I665F probably damaging Het
Spg21 A G 9: 65,473,708 Q99R probably benign Het
St14 A G 9: 31,097,071 probably null Het
Sult1c2 A T 17: 53,830,071 N274K probably benign Het
Syk T C 13: 52,622,732 V256A probably benign Het
Tgm4 C T 9: 123,056,515 T374M probably damaging Het
Tns4 T C 11: 99,068,269 H668R probably damaging Het
Tsn C T 1: 118,305,269 A102T possibly damaging Het
Uvssa T A 5: 33,391,845 S350T possibly damaging Het
Vmn1r3 T A 4: 3,185,214 Y31F possibly damaging Het
Vmn2r114 A T 17: 23,296,996 probably benign Het
Vmn2r27 T C 6: 124,192,317 D618G possibly damaging Het
Vmn2r91 T A 17: 18,110,111 probably benign Het
Vti1a T C 19: 55,391,847 Y143H probably damaging Het
Zfand4 T A 6: 116,273,659 Y17N probably damaging Het
Zfp729a T C 13: 67,619,642 probably null Het
Zfp827 A G 8: 79,060,957 T251A probably damaging Het
Other mutations in Tcte1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Tcte1 APN 17 45534928 missense probably damaging 1.00
IGL00945:Tcte1 APN 17 45541189 missense probably benign 0.15
IGL01120:Tcte1 APN 17 45539668 missense probably damaging 0.99
IGL01132:Tcte1 APN 17 45539862 missense possibly damaging 0.93
IGL01884:Tcte1 APN 17 45539809 unclassified probably null
IGL02418:Tcte1 APN 17 45541202 missense probably benign 0.37
IGL02731:Tcte1 APN 17 45539886 missense probably benign 0.00
R0358:Tcte1 UTSW 17 45535285 missense probably benign 0.34
R1519:Tcte1 UTSW 17 45535252 missense probably damaging 1.00
R2013:Tcte1 UTSW 17 45541311 missense probably benign 0.30
R2014:Tcte1 UTSW 17 45541311 missense probably benign 0.30
R3744:Tcte1 UTSW 17 45539671 missense probably damaging 0.99
R4250:Tcte1 UTSW 17 45539691 missense probably benign 0.04
R4976:Tcte1 UTSW 17 45534928 missense probably damaging 1.00
R5398:Tcte1 UTSW 17 45539826 nonsense probably null
R6169:Tcte1 UTSW 17 45535070 missense probably benign 0.01
R6251:Tcte1 UTSW 17 45535159 missense probably benign
R6279:Tcte1 UTSW 17 45533289 missense possibly damaging 0.69
R6300:Tcte1 UTSW 17 45533289 missense possibly damaging 0.69
R6316:Tcte1 UTSW 17 45534860 missense probably benign
R6417:Tcte1 UTSW 17 45535130 missense probably damaging 0.97
R6892:Tcte1 UTSW 17 45533157 missense probably benign
R7047:Tcte1 UTSW 17 45533368 missense possibly damaging 0.52
R7645:Tcte1 UTSW 17 45534989 missense probably benign 0.00
R8125:Tcte1 UTSW 17 45539692 missense possibly damaging 0.88
Z1176:Tcte1 UTSW 17 45535071 missense probably benign
Z1177:Tcte1 UTSW 17 45535012 missense possibly damaging 0.93
Posted On2016-08-02