Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03131:Zfp759'

410353

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp759

Ensembl Gene

ENSMUSG00000057396

Gene Name

zinc finger protein 759

Synonyms

Rslcan-8

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL03131

Quality Score

Status

Chromosome

Chromosomal Location

67273040-67290468 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 67286728 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 93 (L93P)

Ref Sequence

ENSEMBL: ENSMUSP00000049650 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052716] [ENSMUST00000224346]

AlphaFold

Q7M6X3

Predicted Effect

probably damaging
Transcript: ENSMUST00000052716
AA Change: L93P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000049650
Gene: ENSMUSG00000057396
AA Change: L93P

Domain	Start	End	E-Value	Type
KRAB	5	65	1.6e-22	SMART
ZnF_C2H2	106	128	5.54e1	SMART
ZnF_C2H2	162	184	3.83e-2	SMART
ZnF_C2H2	190	212	1.82e-3	SMART
ZnF_C2H2	218	240	1.64e-1	SMART
ZnF_C2H2	246	268	1.67e-2	SMART
ZnF_C2H2	274	296	1.95e-3	SMART
ZnF_C2H2	302	324	1.84e-4	SMART
ZnF_C2H2	330	352	7.78e-3	SMART
ZnF_C2H2	358	380	1.6e-4	SMART
ZnF_C2H2	386	408	1.67e-2	SMART
ZnF_C2H2	414	436	4.87e-4	SMART
ZnF_C2H2	442	464	3.39e-3	SMART
ZnF_C2H2	498	520	2.57e-3	SMART
ZnF_C2H2	526	548	8.47e-4	SMART
ZnF_C2H2	554	576	2.02e-1	SMART
ZnF_C2H2	582	604	2.53e-2	SMART
ZnF_C2H2	610	632	4.79e-3	SMART
ZnF_C2H2	638	660	1.84e-4	SMART
ZnF_C2H2	666	688	1.36e-2	SMART
ZnF_C2H2	694	716	4.17e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000224346
AA Change: L99P

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224426

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432M17Rik	A	C	3: 121,473,251 (GRCm39)	R135S	unknown	Het
A1bg	T	C	15: 60,791,605 (GRCm39)	Y277C	probably damaging	Het
Abca12	A	T	1: 71,385,861 (GRCm39)	F252L	probably benign	Het
Abcd3	A	T	3: 121,575,640 (GRCm39)		probably benign	Het
Acvr2b	C	A	9: 119,260,350 (GRCm39)	F364L	possibly damaging	Het
Adamts12	T	C	15: 11,345,650 (GRCm39)	C1564R	probably damaging	Het
Agap3	A	G	5: 24,682,130 (GRCm39)	T392A	probably benign	Het
Ano1	A	G	7: 144,157,322 (GRCm39)	F767L	possibly damaging	Het
Atg10	C	A	13: 91,085,412 (GRCm39)	R179I	probably null	Het
Bsph1	A	T	7: 13,207,012 (GRCm39)	K129N	probably damaging	Het
Calml4	A	G	9: 62,782,765 (GRCm39)	D77G	probably benign	Het
Cc2d1a	T	A	8: 84,870,056 (GRCm39)	K153M	probably damaging	Het
Col4a2	G	A	8: 11,475,979 (GRCm39)	V672I	probably benign	Het
Crnkl1	T	C	2: 145,774,178 (GRCm39)	K95R	probably benign	Het
Crtap	T	C	9: 114,209,072 (GRCm39)	D324G	possibly damaging	Het
Csmd1	C	T	8: 16,138,231 (GRCm39)	G1607E	probably damaging	Het
Dcbld2	T	G	16: 58,272,051 (GRCm39)	I369R	probably benign	Het
Dmc1	T	A	15: 79,452,892 (GRCm39)	I246L	probably benign	Het
Dock1	G	T	7: 134,475,912 (GRCm39)	V896L	possibly damaging	Het
Eftud2	G	A	11: 102,761,009 (GRCm39)	T112M	probably damaging	Het
F5	A	T	1: 163,989,388 (GRCm39)	I97F	possibly damaging	Het
Fasn	C	T	11: 120,701,550 (GRCm39)	V1939M	possibly damaging	Het
Gpatch2l	T	C	12: 86,328,285 (GRCm39)	V414A	probably benign	Het
Gpd2	T	C	2: 57,228,855 (GRCm39)		probably benign	Het
Gria4	T	G	9: 4,432,876 (GRCm39)	N769T	probably damaging	Het
Gtf3c2	A	T	5: 31,314,964 (GRCm39)	F885I	probably damaging	Het
Ifi209	C	T	1: 173,468,800 (GRCm39)	T210I	possibly damaging	Het
Kmt2c	A	G	5: 25,520,359 (GRCm39)	V1917A	probably benign	Het
Mad1l1	G	A	5: 140,293,458 (GRCm39)	A120V	probably benign	Het
Mef2c	T	C	13: 83,810,494 (GRCm39)	I382T	probably damaging	Het
Ms4a14	A	T	19: 11,285,056 (GRCm39)	L171I	probably benign	Het
Myf6	T	A	10: 107,330,132 (GRCm39)	Q145L	probably damaging	Het
Myh3	G	A	11: 66,981,935 (GRCm39)		probably benign	Het
Nbas	A	G	12: 13,329,417 (GRCm39)	I121V	probably benign	Het
Ncoa2	A	T	1: 13,247,398 (GRCm39)	S342T	probably damaging	Het
Nlrp1b	C	T	11: 71,052,741 (GRCm39)	D896N	possibly damaging	Het
Prss41	A	G	17: 24,061,498 (GRCm39)	Y98H	probably benign	Het
Ptpn13	A	T	5: 103,665,425 (GRCm39)	T450S	probably benign	Het
Rab39	G	A	9: 53,597,861 (GRCm39)	R135C	probably damaging	Het
Radil	A	G	5: 142,481,097 (GRCm39)	V570A	probably damaging	Het
Sbno1	C	T	5: 124,526,668 (GRCm39)	R949Q	probably damaging	Het
Sec61a2	T	A	2: 5,887,689 (GRCm39)	K98*	probably null	Het
Serbp1	T	A	6: 67,258,807 (GRCm39)		probably null	Het
Serpinb3c	G	T	1: 107,199,457 (GRCm39)	Q355K	probably benign	Het
Slc34a3	T	G	2: 25,121,246 (GRCm39)	D307A	probably benign	Het
Smarcad1	T	A	6: 65,051,937 (GRCm39)	S357T	probably damaging	Het
Spag17	G	A	3: 99,918,075 (GRCm39)	D353N	possibly damaging	Het
Spdl1	T	A	11: 34,721,592 (GRCm39)	Q39L	possibly damaging	Het
Syne2	A	C	12: 76,104,264 (GRCm39)	Q5485P	probably damaging	Het
Synj1	C	A	16: 90,785,056 (GRCm39)	V227F	probably damaging	Het
Syt12	T	C	19: 4,506,882 (GRCm39)	T88A	probably benign	Het
Tasor	C	T	14: 27,183,136 (GRCm39)	Q532*	probably null	Het
Tlr12	A	G	4: 128,509,670 (GRCm39)	F860S	probably damaging	Het
Trdn	C	A	10: 33,274,410 (GRCm39)	S461*	probably null	Het
Trip4	G	A	9: 65,764,727 (GRCm39)	P413S	probably benign	Het
Wdr17	A	G	8: 55,149,302 (GRCm39)		probably null	Het
Wnt9a	T	C	11: 59,221,855 (GRCm39)	L251P	probably damaging	Het
Xrcc1	A	T	7: 24,272,719 (GRCm39)	K618*	probably null	Het

Other mutations in Zfp759

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01509:Zfp759	APN	13	67,287,658 (GRCm39)	missense	probably benign	0.25
IGL03218:Zfp759	APN	13	67,287,480 (GRCm39)	missense	probably benign	0.00
R0243:Zfp759	UTSW	13	67,286,877 (GRCm39)	missense	possibly damaging	0.66
R0319:Zfp759	UTSW	13	67,288,356 (GRCm39)	missense	probably benign	0.00
R0520:Zfp759	UTSW	13	67,285,419 (GRCm39)	missense	probably benign	0.29
R0961:Zfp759	UTSW	13	67,287,927 (GRCm39)	missense	probably benign	0.32
R1435:Zfp759	UTSW	13	67,286,830 (GRCm39)	missense	possibly damaging	0.73
R1649:Zfp759	UTSW	13	67,287,668 (GRCm39)	missense	probably benign	0.00
R1880:Zfp759	UTSW	13	67,287,276 (GRCm39)	missense	probably damaging	1.00
R2118:Zfp759	UTSW	13	67,287,578 (GRCm39)	unclassified	probably benign
R2170:Zfp759	UTSW	13	67,284,812 (GRCm39)	missense	possibly damaging	0.88
R3154:Zfp759	UTSW	13	67,286,719 (GRCm39)	missense	probably benign	0.20
R3551:Zfp759	UTSW	13	67,287,031 (GRCm39)	missense	probably benign	0.24
R4392:Zfp759	UTSW	13	67,287,707 (GRCm39)	nonsense	probably null
R4495:Zfp759	UTSW	13	67,286,989 (GRCm39)	splice site	probably null
R4736:Zfp759	UTSW	13	67,287,408 (GRCm39)	missense	probably damaging	1.00
R4882:Zfp759	UTSW	13	67,287,354 (GRCm39)	missense	probably damaging	1.00
R5717:Zfp759	UTSW	13	67,286,772 (GRCm39)	missense	probably damaging	1.00
R5921:Zfp759	UTSW	13	67,288,558 (GRCm39)	missense	probably damaging	1.00
R6247:Zfp759	UTSW	13	67,288,524 (GRCm39)	missense	probably benign	0.00
R6381:Zfp759	UTSW	13	67,286,969 (GRCm39)	nonsense	probably null
R6427:Zfp759	UTSW	13	67,287,162 (GRCm39)	splice site	probably null
R6567:Zfp759	UTSW	13	67,287,150 (GRCm39)	missense	probably benign	0.34
R7140:Zfp759	UTSW	13	67,288,177 (GRCm39)	missense	possibly damaging	0.92
R7731:Zfp759	UTSW	13	67,287,690 (GRCm39)	missense	possibly damaging	0.82
R8504:Zfp759	UTSW	13	67,286,947 (GRCm39)	missense	probably benign	0.00
R8770:Zfp759	UTSW	13	67,288,417 (GRCm39)	missense	probably damaging	1.00
R9250:Zfp759	UTSW	13	67,288,461 (GRCm39)	missense	probably damaging	1.00
R9695:Zfp759	UTSW	13	67,287,198 (GRCm39)	missense	possibly damaging	0.94
Z1176:Zfp759	UTSW	13	67,284,872 (GRCm39)	missense	probably damaging	0.98
Z1177:Zfp759	UTSW	13	67,288,212 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02