Incidental Mutation 'IGL03132:Adam21'
ID 410371
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adam21
Ensembl Gene ENSMUSG00000008438
Gene Name a disintegrin and metallopeptidase domain 21
Synonyms ADAM31
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03132
Quality Score
Status
Chromosome 12
Chromosomal Location 81605358-81615248 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 81607148 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 205 (G205*)
Ref Sequence ENSEMBL: ENSMUSP00000008582 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000008582]
AlphaFold Q9JI76
Predicted Effect probably null
Transcript: ENSMUST00000008582
AA Change: G205*
SMART Domains Protein: ENSMUSP00000008582
Gene: ENSMUSG00000008438
AA Change: G205*

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:Pep_M12B_propep 39 164 5.1e-21 PFAM
Pfam:Reprolysin_4 212 389 2.5e-11 PFAM
Pfam:Reprolysin 212 402 7.3e-50 PFAM
Pfam:Reprolysin_5 214 400 5.8e-19 PFAM
Pfam:Reprolysin_2 233 393 1.3e-14 PFAM
Pfam:Reprolysin_3 236 356 6.5e-16 PFAM
DISIN 419 494 2.45e-37 SMART
ACR 495 631 6.49e-62 SMART
EGF 637 667 2.03e1 SMART
transmembrane domain 687 709 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166971
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. The encoded protein functions in the regulation of spermatogenesis in the testes and neurogenesis in the central nervous system. [provided by RefSeq, May 2016]
PHENOTYPE: Mice homozygous for disruptions in this gene display a normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb1 G A 6: 88,815,941 (GRCm39) R177C probably benign Het
Baz2b T A 2: 59,738,097 (GRCm39) probably benign Het
Col6a3 C T 1: 90,731,615 (GRCm39) G939D probably damaging Het
Csf1r A G 18: 61,261,171 (GRCm39) E749G probably benign Het
Dnm3 C T 1: 161,838,674 (GRCm39) probably null Het
Dsg3 A G 18: 20,657,653 (GRCm39) D241G probably damaging Het
Dst T C 1: 34,295,722 (GRCm39) S6015P probably benign Het
Dvl2 T C 11: 69,896,514 (GRCm39) S183P probably benign Het
Exoc6b T C 6: 84,768,246 (GRCm39) N699S possibly damaging Het
Fat2 T C 11: 55,144,746 (GRCm39) R4043G probably benign Het
Gbp9 T A 5: 105,232,819 (GRCm39) T278S possibly damaging Het
Gm2a T A 11: 54,994,474 (GRCm39) I48N probably damaging Het
Gorasp2 T C 2: 70,514,379 (GRCm39) V232A probably benign Het
Gpa33 G A 1: 165,980,218 (GRCm39) D94N probably benign Het
Il1rap A T 16: 26,498,869 (GRCm39) S123C probably damaging Het
Kctd17 T C 15: 78,319,887 (GRCm39) S102P probably damaging Het
Lamb1 A G 12: 31,350,333 (GRCm39) probably null Het
Mfsd1 T A 3: 67,495,273 (GRCm39) I131K possibly damaging Het
Pkhd1l1 G A 15: 44,438,013 (GRCm39) C3576Y probably damaging Het
Pla2g4a A T 1: 149,778,035 (GRCm39) probably benign Het
Ptpn11 T A 5: 121,272,878 (GRCm39) D575V possibly damaging Het
Reck A T 4: 43,938,898 (GRCm39) R755* probably null Het
Scgb2b21 A G 7: 33,219,299 (GRCm39) V35A possibly damaging Het
Srpra G A 9: 35,125,574 (GRCm39) probably null Het
Stk11ip T C 1: 75,512,733 (GRCm39) S1025P probably benign Het
Tmprss9 G A 10: 80,730,699 (GRCm39) V742M probably damaging Het
Trh T C 6: 92,220,755 (GRCm39) T36A probably benign Het
Trim35 A G 14: 66,546,595 (GRCm39) E454G probably damaging Het
Vmn2r99 C T 17: 19,598,485 (GRCm39) Q170* probably null Het
Other mutations in Adam21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02186:Adam21 APN 12 81,605,983 (GRCm39) missense possibly damaging 0.61
IGL02311:Adam21 APN 12 81,607,666 (GRCm39) missense probably benign 0.01
IGL03225:Adam21 APN 12 81,606,043 (GRCm39) missense probably benign 0.00
BB009:Adam21 UTSW 12 81,606,938 (GRCm39) missense probably damaging 0.98
BB019:Adam21 UTSW 12 81,606,938 (GRCm39) missense probably damaging 0.98
R0305:Adam21 UTSW 12 81,607,059 (GRCm39) missense possibly damaging 0.96
R0634:Adam21 UTSW 12 81,607,126 (GRCm39) missense probably benign 0.01
R1415:Adam21 UTSW 12 81,606,321 (GRCm39) nonsense probably null
R1961:Adam21 UTSW 12 81,606,282 (GRCm39) nonsense probably null
R1996:Adam21 UTSW 12 81,606,376 (GRCm39) missense possibly damaging 0.79
R2159:Adam21 UTSW 12 81,607,241 (GRCm39) missense probably benign 0.17
R2215:Adam21 UTSW 12 81,607,064 (GRCm39) missense probably damaging 1.00
R3780:Adam21 UTSW 12 81,606,047 (GRCm39) missense probably damaging 1.00
R3964:Adam21 UTSW 12 81,607,583 (GRCm39) missense possibly damaging 0.46
R4356:Adam21 UTSW 12 81,605,594 (GRCm39) missense probably damaging 0.99
R4503:Adam21 UTSW 12 81,607,672 (GRCm39) missense probably benign
R4795:Adam21 UTSW 12 81,607,748 (GRCm39) missense probably benign 0.06
R4925:Adam21 UTSW 12 81,607,163 (GRCm39) missense probably benign
R4932:Adam21 UTSW 12 81,605,692 (GRCm39) missense probably benign 0.14
R5110:Adam21 UTSW 12 81,606,989 (GRCm39) missense probably benign 0.40
R5831:Adam21 UTSW 12 81,605,875 (GRCm39) missense probably benign 0.06
R6289:Adam21 UTSW 12 81,607,480 (GRCm39) missense probably damaging 1.00
R6500:Adam21 UTSW 12 81,606,380 (GRCm39) missense probably benign 0.01
R7077:Adam21 UTSW 12 81,605,893 (GRCm39) missense probably damaging 1.00
R7083:Adam21 UTSW 12 81,607,015 (GRCm39) missense possibly damaging 0.81
R7173:Adam21 UTSW 12 81,606,008 (GRCm39) missense probably benign 0.24
R7176:Adam21 UTSW 12 81,607,022 (GRCm39) missense possibly damaging 0.94
R7232:Adam21 UTSW 12 81,607,330 (GRCm39) missense probably damaging 0.99
R7371:Adam21 UTSW 12 81,607,064 (GRCm39) missense probably damaging 1.00
R7486:Adam21 UTSW 12 81,605,657 (GRCm39) missense probably benign 0.00
R7522:Adam21 UTSW 12 81,605,722 (GRCm39) missense possibly damaging 0.78
R7918:Adam21 UTSW 12 81,607,378 (GRCm39) missense possibly damaging 0.64
R7932:Adam21 UTSW 12 81,606,938 (GRCm39) missense probably damaging 0.98
R8040:Adam21 UTSW 12 81,607,211 (GRCm39) missense probably benign 0.04
R8486:Adam21 UTSW 12 81,607,550 (GRCm39) missense probably benign 0.08
R8750:Adam21 UTSW 12 81,607,247 (GRCm39) nonsense probably null
R8881:Adam21 UTSW 12 81,606,650 (GRCm39) missense probably benign 0.02
R9084:Adam21 UTSW 12 81,606,160 (GRCm39) missense probably damaging 1.00
R9541:Adam21 UTSW 12 81,607,724 (GRCm39) missense probably benign
R9564:Adam21 UTSW 12 81,605,833 (GRCm39) missense probably damaging 1.00
Z1088:Adam21 UTSW 12 81,607,460 (GRCm39) missense probably damaging 1.00
Z1176:Adam21 UTSW 12 81,606,517 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02