Incidental Mutation 'IGL03132:Trim35'
ID 410379
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim35
Ensembl Gene ENSMUSG00000022043
Gene Name tripartite motif-containing 35
Synonyms A430106H13Rik, Hls5, Mair, 0710005M05Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL03132
Quality Score
Status
Chromosome 14
Chromosomal Location 66534480-66548873 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 66546595 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 454 (E454G)
Ref Sequence ENSEMBL: ENSMUSP00000022623 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022623]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000022623
AA Change: E454G

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000022623
Gene: ENSMUSG00000022043
AA Change: E454G

DomainStartEndE-ValueType
low complexity region 3 15 N/A INTRINSIC
low complexity region 18 29 N/A INTRINSIC
RING 36 75 6.89e-8 SMART
BBOX 111 152 1.27e-6 SMART
coiled coil region 219 267 N/A INTRINSIC
PRY 316 367 4.41e-15 SMART
Pfam:SPRY 370 495 3.5e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121006
SMART Domains Protein: ENSMUSP00000112877
Gene: ENSMUSG00000022043

DomainStartEndE-ValueType
low complexity region 12 23 N/A INTRINSIC
RING 30 69 6.89e-8 SMART
BBOX 105 146 1.27e-6 SMART
coiled coil region 212 260 N/A INTRINSIC
low complexity region 330 343 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb1 G A 6: 88,815,941 (GRCm39) R177C probably benign Het
Adam21 C A 12: 81,607,148 (GRCm39) G205* probably null Het
Baz2b T A 2: 59,738,097 (GRCm39) probably benign Het
Col6a3 C T 1: 90,731,615 (GRCm39) G939D probably damaging Het
Csf1r A G 18: 61,261,171 (GRCm39) E749G probably benign Het
Dnm3 C T 1: 161,838,674 (GRCm39) probably null Het
Dsg3 A G 18: 20,657,653 (GRCm39) D241G probably damaging Het
Dst T C 1: 34,295,722 (GRCm39) S6015P probably benign Het
Dvl2 T C 11: 69,896,514 (GRCm39) S183P probably benign Het
Exoc6b T C 6: 84,768,246 (GRCm39) N699S possibly damaging Het
Fat2 T C 11: 55,144,746 (GRCm39) R4043G probably benign Het
Gbp9 T A 5: 105,232,819 (GRCm39) T278S possibly damaging Het
Gm2a T A 11: 54,994,474 (GRCm39) I48N probably damaging Het
Gorasp2 T C 2: 70,514,379 (GRCm39) V232A probably benign Het
Gpa33 G A 1: 165,980,218 (GRCm39) D94N probably benign Het
Il1rap A T 16: 26,498,869 (GRCm39) S123C probably damaging Het
Kctd17 T C 15: 78,319,887 (GRCm39) S102P probably damaging Het
Lamb1 A G 12: 31,350,333 (GRCm39) probably null Het
Mfsd1 T A 3: 67,495,273 (GRCm39) I131K possibly damaging Het
Pkhd1l1 G A 15: 44,438,013 (GRCm39) C3576Y probably damaging Het
Pla2g4a A T 1: 149,778,035 (GRCm39) probably benign Het
Ptpn11 T A 5: 121,272,878 (GRCm39) D575V possibly damaging Het
Reck A T 4: 43,938,898 (GRCm39) R755* probably null Het
Scgb2b21 A G 7: 33,219,299 (GRCm39) V35A possibly damaging Het
Srpra G A 9: 35,125,574 (GRCm39) probably null Het
Stk11ip T C 1: 75,512,733 (GRCm39) S1025P probably benign Het
Tmprss9 G A 10: 80,730,699 (GRCm39) V742M probably damaging Het
Trh T C 6: 92,220,755 (GRCm39) T36A probably benign Het
Vmn2r99 C T 17: 19,598,485 (GRCm39) Q170* probably null Het
Other mutations in Trim35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01652:Trim35 APN 14 66,546,250 (GRCm39) missense probably damaging 1.00
IGL02398:Trim35 APN 14 66,546,697 (GRCm39) missense probably damaging 1.00
R0759:Trim35 UTSW 14 66,546,236 (GRCm39) missense probably benign 0.02
R0799:Trim35 UTSW 14 66,546,650 (GRCm39) missense probably damaging 1.00
R0848:Trim35 UTSW 14 66,546,574 (GRCm39) missense probably benign 0.01
R1170:Trim35 UTSW 14 66,546,248 (GRCm39) missense probably benign 0.35
R1734:Trim35 UTSW 14 66,546,778 (GRCm39) missense probably damaging 0.99
R1751:Trim35 UTSW 14 66,541,617 (GRCm39) missense probably damaging 0.97
R1767:Trim35 UTSW 14 66,541,617 (GRCm39) missense probably damaging 0.97
R2259:Trim35 UTSW 14 66,546,711 (GRCm39) nonsense probably null
R3963:Trim35 UTSW 14 66,541,503 (GRCm39) missense probably damaging 1.00
R4572:Trim35 UTSW 14 66,545,322 (GRCm39) missense probably damaging 1.00
R5068:Trim35 UTSW 14 66,546,421 (GRCm39) unclassified probably benign
R5069:Trim35 UTSW 14 66,546,421 (GRCm39) unclassified probably benign
R5070:Trim35 UTSW 14 66,546,421 (GRCm39) unclassified probably benign
R5372:Trim35 UTSW 14 66,534,715 (GRCm39) missense possibly damaging 0.69
R5886:Trim35 UTSW 14 66,541,503 (GRCm39) missense probably damaging 1.00
R5886:Trim35 UTSW 14 66,541,502 (GRCm39) missense possibly damaging 0.92
R6018:Trim35 UTSW 14 66,546,199 (GRCm39) missense probably damaging 1.00
R6165:Trim35 UTSW 14 66,546,654 (GRCm39) missense probably damaging 1.00
R6326:Trim35 UTSW 14 66,540,653 (GRCm39) missense possibly damaging 0.52
R6476:Trim35 UTSW 14 66,546,244 (GRCm39) missense probably damaging 1.00
R7084:Trim35 UTSW 14 66,546,271 (GRCm39) missense probably damaging 0.98
R7192:Trim35 UTSW 14 66,534,895 (GRCm39) missense probably damaging 1.00
R7350:Trim35 UTSW 14 66,546,654 (GRCm39) missense probably damaging 1.00
R7546:Trim35 UTSW 14 66,540,696 (GRCm39) missense probably benign 0.02
R7644:Trim35 UTSW 14 66,534,546 (GRCm39) missense unknown
R7916:Trim35 UTSW 14 66,546,309 (GRCm39) missense probably damaging 1.00
R8406:Trim35 UTSW 14 66,534,724 (GRCm39) missense possibly damaging 0.91
R8524:Trim35 UTSW 14 66,544,493 (GRCm39) missense probably damaging 1.00
R8710:Trim35 UTSW 14 66,545,367 (GRCm39) missense probably damaging 0.99
Posted On 2016-08-02