Incidental Mutation 'IGL03135:Vmn2r60'
ID 410465
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r60
Ensembl Gene ENSMUSG00000090619
Gene Name vomeronasal 2, receptor 60
Synonyms Gprc2a-rs3, Casr-rs3, EG637898
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # IGL03135
Quality Score
Status
Chromosome 7
Chromosomal Location 42116471-42195776 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 42136594 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 274 (I274V)
Ref Sequence ENSEMBL: ENSMUSP00000128493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166447]
AlphaFold A0A3B2WBC8
Predicted Effect probably benign
Transcript: ENSMUST00000166447
AA Change: I274V

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
AA Change: I274V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 78 471 1.2e-44 PFAM
Pfam:NCD3G 514 567 5.1e-23 PFAM
Pfam:7tm_3 600 835 1.4e-51 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apmap A C 2: 150,587,115 (GRCm38) M196R possibly damaging Het
Arhgap27 T A 11: 103,339,065 (GRCm38) probably null Het
Arl8b A C 6: 108,818,545 (GRCm38) N148T probably benign Het
Baz1a A G 12: 54,929,590 (GRCm38) F434L probably damaging Het
Birc3 A G 9: 7,849,721 (GRCm38) probably benign Het
Brwd1 C A 16: 96,021,258 (GRCm38) R1249I probably damaging Het
Cab39l T C 14: 59,519,651 (GRCm38) F161L probably benign Het
Ccr8 A T 9: 120,094,623 (GRCm38) D268V possibly damaging Het
Col25a1 A T 3: 130,529,683 (GRCm38) probably benign Het
Cpn1 A G 19: 43,986,254 (GRCm38) L12P possibly damaging Het
Dnah6 A G 6: 73,145,004 (GRCm38) I1360T probably benign Het
Dnajb8 A G 6: 88,223,031 (GRCm38) E183G probably damaging Het
Dpp8 T A 9: 65,053,040 (GRCm38) probably null Het
Fsd1 C A 17: 55,990,416 (GRCm38) probably null Het
Grina T A 15: 76,247,962 (GRCm38) F28I possibly damaging Het
H2-M3 G A 17: 37,272,433 (GRCm38) D262N possibly damaging Het
Hdgfl3 G A 7: 81,893,839 (GRCm38) T188M probably damaging Het
Kif18b A G 11: 102,914,260 (GRCm38) I353T probably damaging Het
Lrrc41 C A 4: 116,088,531 (GRCm38) R148S probably benign Het
Lrrc8e T A 8: 4,235,776 (GRCm38) L667Q probably damaging Het
Lrrk1 A G 7: 66,262,890 (GRCm38) F1641L probably benign Het
Naaladl1 A T 19: 6,112,356 (GRCm38) T443S probably benign Het
Naga C A 15: 82,330,741 (GRCm38) V339F probably damaging Het
Nedd4l A G 18: 65,205,670 (GRCm38) K702E probably damaging Het
Nwd2 T A 5: 63,805,995 (GRCm38) L974H probably damaging Het
Parp14 A G 16: 35,858,011 (GRCm38) M529T probably damaging Het
Parp8 A G 13: 116,910,942 (GRCm38) V198A probably benign Het
Pcdhb19 A T 18: 37,498,535 (GRCm38) H461L probably benign Het
Ppp6r1 T C 7: 4,642,160 (GRCm38) D236G possibly damaging Het
Psg21 T C 7: 18,654,918 (GRCm38) D83G probably benign Het
Ptpru A G 4: 131,818,800 (GRCm38) C308R probably damaging Het
Ralgds T A 2: 28,549,088 (GRCm38) S696T probably damaging Het
Rttn T A 18: 89,015,150 (GRCm38) L695Q probably damaging Het
Scel A T 14: 103,586,514 (GRCm38) I393F probably benign Het
Serpina3j T A 12: 104,314,907 (GRCm38) I113N probably damaging Het
Slc4a3 C A 1: 75,547,935 (GRCm38) probably benign Het
Slc6a11 A T 6: 114,194,609 (GRCm38) probably null Het
Slc8a3 C T 12: 81,202,249 (GRCm38) V802M probably damaging Het
Smarcal1 T A 1: 72,616,501 (GRCm38) probably null Het
Tmprss11c A G 5: 86,237,650 (GRCm38) V308A probably damaging Het
Trim10 A G 17: 36,874,221 (GRCm38) R279G possibly damaging Het
Trim30a A G 7: 104,411,141 (GRCm38) V476A probably damaging Het
Trio T C 15: 27,832,011 (GRCm38) probably benign Het
Urgcp G A 11: 5,716,091 (GRCm38) T749I possibly damaging Het
Vps11 A G 9: 44,356,356 (GRCm38) F40L probably benign Het
Ywhab A G 2: 164,015,275 (GRCm38) I157V probably benign Het
Zfp638 G A 6: 83,942,875 (GRCm38) R485H probably damaging Het
Zfp944 A G 17: 22,339,756 (GRCm38) I170T probably benign Het
Other mutations in Vmn2r60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01622:Vmn2r60 APN 7 42,136,486 (GRCm38) missense probably benign 0.09
IGL01623:Vmn2r60 APN 7 42,136,486 (GRCm38) missense probably benign 0.09
IGL02363:Vmn2r60 APN 7 42,195,154 (GRCm38) missense probably benign 0.02
IGL02485:Vmn2r60 APN 7 42,195,466 (GRCm38) missense possibly damaging 0.54
IGL02651:Vmn2r60 APN 7 42,195,586 (GRCm38) missense probably damaging 0.99
IGL02660:Vmn2r60 APN 7 42,142,296 (GRCm38) nonsense probably null
IGL03307:Vmn2r60 APN 7 42,116,547 (GRCm38) missense probably benign 0.14
R0310:Vmn2r60 UTSW 7 42,195,140 (GRCm38) missense possibly damaging 0.54
R0314:Vmn2r60 UTSW 7 42,135,561 (GRCm38) splice site probably benign
R0328:Vmn2r60 UTSW 7 42,142,320 (GRCm38) splice site probably benign
R0464:Vmn2r60 UTSW 7 42,135,831 (GRCm38) missense probably damaging 0.99
R0755:Vmn2r60 UTSW 7 42,195,445 (GRCm38) missense probably damaging 1.00
R1119:Vmn2r60 UTSW 7 42,194,941 (GRCm38) missense possibly damaging 0.68
R1162:Vmn2r60 UTSW 7 42,195,771 (GRCm38) missense probably benign 0.29
R1241:Vmn2r60 UTSW 7 42,137,052 (GRCm38) missense probably benign 0.01
R1404:Vmn2r60 UTSW 7 42,136,787 (GRCm38) missense probably damaging 0.99
R1404:Vmn2r60 UTSW 7 42,136,787 (GRCm38) missense probably damaging 0.99
R1488:Vmn2r60 UTSW 7 42,136,713 (GRCm38) missense probably benign 0.17
R1623:Vmn2r60 UTSW 7 42,135,855 (GRCm38) nonsense probably null
R1628:Vmn2r60 UTSW 7 42,136,406 (GRCm38) nonsense probably null
R1883:Vmn2r60 UTSW 7 42,136,670 (GRCm38) missense probably damaging 0.99
R1884:Vmn2r60 UTSW 7 42,136,670 (GRCm38) missense probably damaging 0.99
R2182:Vmn2r60 UTSW 7 42,195,507 (GRCm38) missense probably benign 0.06
R2275:Vmn2r60 UTSW 7 42,136,827 (GRCm38) nonsense probably null
R2847:Vmn2r60 UTSW 7 42,136,433 (GRCm38) missense probably benign 0.07
R2885:Vmn2r60 UTSW 7 42,140,979 (GRCm38) missense possibly damaging 0.91
R2894:Vmn2r60 UTSW 7 42,135,796 (GRCm38) missense probably benign
R2921:Vmn2r60 UTSW 7 42,141,035 (GRCm38) missense probably damaging 0.98
R2922:Vmn2r60 UTSW 7 42,141,035 (GRCm38) missense probably damaging 0.98
R3772:Vmn2r60 UTSW 7 42,116,556 (GRCm38) missense probably benign 0.35
R3820:Vmn2r60 UTSW 7 42,135,701 (GRCm38) missense probably damaging 0.98
R3822:Vmn2r60 UTSW 7 42,135,701 (GRCm38) missense probably damaging 0.98
R3872:Vmn2r60 UTSW 7 42,136,454 (GRCm38) missense probably benign 0.19
R4222:Vmn2r60 UTSW 7 42,116,528 (GRCm38) missense probably benign 0.08
R4223:Vmn2r60 UTSW 7 42,116,528 (GRCm38) missense probably benign 0.08
R4224:Vmn2r60 UTSW 7 42,116,528 (GRCm38) missense probably benign 0.08
R4526:Vmn2r60 UTSW 7 42,195,243 (GRCm38) missense probably damaging 0.96
R4547:Vmn2r60 UTSW 7 42,135,663 (GRCm38) missense probably null 0.54
R4840:Vmn2r60 UTSW 7 42,135,861 (GRCm38) missense probably damaging 1.00
R5173:Vmn2r60 UTSW 7 42,195,511 (GRCm38) missense probably damaging 0.97
R5231:Vmn2r60 UTSW 7 42,137,024 (GRCm38) missense possibly damaging 0.93
R5480:Vmn2r60 UTSW 7 42,135,730 (GRCm38) missense probably damaging 0.98
R5521:Vmn2r60 UTSW 7 42,195,625 (GRCm38) missense probably damaging 0.99
R5834:Vmn2r60 UTSW 7 42,116,508 (GRCm38) missense probably benign 0.17
R6038:Vmn2r60 UTSW 7 42,194,962 (GRCm38) missense probably benign 0.04
R6038:Vmn2r60 UTSW 7 42,194,962 (GRCm38) missense probably benign 0.04
R6112:Vmn2r60 UTSW 7 42,195,423 (GRCm38) missense probably damaging 1.00
R6149:Vmn2r60 UTSW 7 42,136,976 (GRCm38) missense probably damaging 1.00
R6170:Vmn2r60 UTSW 7 42,135,621 (GRCm38) missense possibly damaging 0.94
R6383:Vmn2r60 UTSW 7 42,116,471 (GRCm38) start codon destroyed probably null 0.04
R6811:Vmn2r60 UTSW 7 42,194,886 (GRCm38) missense probably damaging 1.00
R6876:Vmn2r60 UTSW 7 42,135,663 (GRCm38) missense probably null 0.54
R6997:Vmn2r60 UTSW 7 42,142,292 (GRCm38) missense probably benign 0.00
R7040:Vmn2r60 UTSW 7 42,142,242 (GRCm38) missense probably benign 0.00
R7116:Vmn2r60 UTSW 7 42,137,063 (GRCm38) missense probably benign 0.00
R7128:Vmn2r60 UTSW 7 42,195,112 (GRCm38) missense probably damaging 0.96
R7232:Vmn2r60 UTSW 7 42,136,742 (GRCm38) missense possibly damaging 0.83
R7296:Vmn2r60 UTSW 7 42,136,402 (GRCm38) missense probably benign 0.01
R7376:Vmn2r60 UTSW 7 42,195,207 (GRCm38) missense probably damaging 1.00
R7526:Vmn2r60 UTSW 7 42,195,734 (GRCm38) frame shift probably null
R7527:Vmn2r60 UTSW 7 42,195,734 (GRCm38) frame shift probably null
R7528:Vmn2r60 UTSW 7 42,195,734 (GRCm38) frame shift probably null
R7764:Vmn2r60 UTSW 7 42,195,111 (GRCm38) missense probably damaging 0.99
R7843:Vmn2r60 UTSW 7 42,195,087 (GRCm38) missense probably benign 0.00
R8080:Vmn2r60 UTSW 7 42,141,097 (GRCm38) missense probably benign 0.30
R8290:Vmn2r60 UTSW 7 42,142,266 (GRCm38) missense probably damaging 1.00
R8342:Vmn2r60 UTSW 7 42,141,070 (GRCm38) missense possibly damaging 0.63
R8362:Vmn2r60 UTSW 7 42,195,530 (GRCm38) missense probably damaging 1.00
R8418:Vmn2r60 UTSW 7 42,195,426 (GRCm38) missense probably damaging 0.97
R8848:Vmn2r60 UTSW 7 42,136,745 (GRCm38) missense probably damaging 1.00
R8860:Vmn2r60 UTSW 7 42,142,230 (GRCm38) missense probably damaging 0.99
R8882:Vmn2r60 UTSW 7 42,141,094 (GRCm38) missense probably benign 0.00
R8913:Vmn2r60 UTSW 7 42,136,354 (GRCm38) missense probably benign 0.27
R9190:Vmn2r60 UTSW 7 42,195,511 (GRCm38) missense probably damaging 0.99
R9229:Vmn2r60 UTSW 7 42,142,299 (GRCm38) missense possibly damaging 0.95
R9295:Vmn2r60 UTSW 7 42,136,531 (GRCm38) missense probably benign 0.01
R9335:Vmn2r60 UTSW 7 42,194,908 (GRCm38) missense probably damaging 1.00
R9796:Vmn2r60 UTSW 7 42,135,748 (GRCm38) missense probably benign
RF024:Vmn2r60 UTSW 7 42,140,939 (GRCm38) missense probably benign 0.01
X0023:Vmn2r60 UTSW 7 42,141,114 (GRCm38) missense probably benign 0.01
Posted On 2016-08-02