Incidental Mutation 'IGL03135:Trim10'
ID 410468
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim10
Ensembl Gene ENSMUSG00000073400
Gene Name tripartite motif-containing 10
Synonyms Rnf9, Herf1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # IGL03135
Quality Score
Status
Chromosome 17
Chromosomal Location 37180466-37188725 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37185113 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 279 (R279G)
Ref Sequence ENSEMBL: ENSMUSP00000057928 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060524]
AlphaFold Q9WUH5
Predicted Effect possibly damaging
Transcript: ENSMUST00000060524
AA Change: R279G

PolyPhen 2 Score 0.783 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000057928
Gene: ENSMUSG00000073400
AA Change: R279G

DomainStartEndE-ValueType
RING 16 60 1.2e-7 SMART
BBOX 94 135 5.38e-10 SMART
coiled coil region 152 175 N/A INTRINSIC
low complexity region 187 207 N/A INTRINSIC
PRY 309 361 1.04e-25 SMART
SPRY 362 485 1.51e-23 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apmap A C 2: 150,429,035 (GRCm39) M196R possibly damaging Het
Arhgap27 T A 11: 103,229,891 (GRCm39) probably null Het
Arl8b A C 6: 108,795,506 (GRCm39) N148T probably benign Het
Baz1a A G 12: 54,976,375 (GRCm39) F434L probably damaging Het
Birc2 A G 9: 7,849,722 (GRCm39) probably benign Het
Brwd1 C A 16: 95,822,458 (GRCm39) R1249I probably damaging Het
Cab39l T C 14: 59,757,100 (GRCm39) F161L probably benign Het
Ccr8 A T 9: 119,923,689 (GRCm39) D268V possibly damaging Het
Col25a1 A T 3: 130,323,332 (GRCm39) probably benign Het
Cpn1 A G 19: 43,974,693 (GRCm39) L12P possibly damaging Het
Dnah6 A G 6: 73,121,987 (GRCm39) I1360T probably benign Het
Dnajb8 A G 6: 88,200,013 (GRCm39) E183G probably damaging Het
Dpp8 T A 9: 64,960,322 (GRCm39) probably null Het
Fsd1 C A 17: 56,297,416 (GRCm39) probably null Het
Grina T A 15: 76,132,162 (GRCm39) F28I possibly damaging Het
H2-M3 G A 17: 37,583,324 (GRCm39) D262N possibly damaging Het
Hdgfl3 G A 7: 81,543,587 (GRCm39) T188M probably damaging Het
Kif18b A G 11: 102,805,086 (GRCm39) I353T probably damaging Het
Lrrc41 C A 4: 115,945,728 (GRCm39) R148S probably benign Het
Lrrc8e T A 8: 4,285,776 (GRCm39) L667Q probably damaging Het
Lrrk1 A G 7: 65,912,638 (GRCm39) F1641L probably benign Het
Naaladl1 A T 19: 6,162,386 (GRCm39) T443S probably benign Het
Naga C A 15: 82,214,942 (GRCm39) V339F probably damaging Het
Nedd4l A G 18: 65,338,741 (GRCm39) K702E probably damaging Het
Nwd2 T A 5: 63,963,338 (GRCm39) L974H probably damaging Het
Parp14 A G 16: 35,678,381 (GRCm39) M529T probably damaging Het
Parp8 A G 13: 117,047,478 (GRCm39) V198A probably benign Het
Pcdhb19 A T 18: 37,631,588 (GRCm39) H461L probably benign Het
Ppp6r1 T C 7: 4,645,159 (GRCm39) D236G possibly damaging Het
Psg21 T C 7: 18,388,843 (GRCm39) D83G probably benign Het
Ptpru A G 4: 131,546,111 (GRCm39) C308R probably damaging Het
Ralgds T A 2: 28,439,100 (GRCm39) S696T probably damaging Het
Rttn T A 18: 89,033,274 (GRCm39) L695Q probably damaging Het
Scel A T 14: 103,823,950 (GRCm39) I393F probably benign Het
Serpina3j T A 12: 104,281,166 (GRCm39) I113N probably damaging Het
Slc4a3 C A 1: 75,524,579 (GRCm39) probably benign Het
Slc6a11 A T 6: 114,171,570 (GRCm39) probably null Het
Slc8a3 C T 12: 81,249,023 (GRCm39) V802M probably damaging Het
Smarcal1 T A 1: 72,655,660 (GRCm39) probably null Het
Tmprss11c A G 5: 86,385,509 (GRCm39) V308A probably damaging Het
Trim30a A G 7: 104,060,348 (GRCm39) V476A probably damaging Het
Trio T C 15: 27,832,097 (GRCm39) probably benign Het
Urgcp G A 11: 5,666,091 (GRCm39) T749I possibly damaging Het
Vmn2r60 A G 7: 41,786,018 (GRCm39) I274V probably benign Het
Vps11 A G 9: 44,267,653 (GRCm39) F40L probably benign Het
Ywhab A G 2: 163,857,195 (GRCm39) I157V probably benign Het
Zfp638 G A 6: 83,919,857 (GRCm39) R485H probably damaging Het
Zfp944 A G 17: 22,558,737 (GRCm39) I170T probably benign Het
Other mutations in Trim10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Trim10 APN 17 37,188,140 (GRCm39) missense probably benign 0.03
IGL00501:Trim10 APN 17 37,187,939 (GRCm39) missense probably benign 0.08
IGL00846:Trim10 APN 17 37,182,584 (GRCm39) missense probably damaging 1.00
IGL01536:Trim10 APN 17 37,188,180 (GRCm39) splice site probably null
IGL02814:Trim10 APN 17 37,188,228 (GRCm39) nonsense probably null
IGL03144:Trim10 APN 17 37,187,740 (GRCm39) missense probably damaging 1.00
IGL03298:Trim10 APN 17 37,187,917 (GRCm39) missense possibly damaging 0.87
PIT4378001:Trim10 UTSW 17 37,188,020 (GRCm39) missense probably damaging 0.98
R0102:Trim10 UTSW 17 37,181,074 (GRCm39) missense probably damaging 1.00
R0102:Trim10 UTSW 17 37,181,074 (GRCm39) missense probably damaging 1.00
R0834:Trim10 UTSW 17 37,183,283 (GRCm39) missense probably benign 0.00
R1517:Trim10 UTSW 17 37,183,346 (GRCm39) missense probably damaging 1.00
R1691:Trim10 UTSW 17 37,187,791 (GRCm39) missense probably damaging 1.00
R1696:Trim10 UTSW 17 37,188,073 (GRCm39) nonsense probably null
R2149:Trim10 UTSW 17 37,187,906 (GRCm39) missense probably benign 0.18
R3153:Trim10 UTSW 17 37,182,580 (GRCm39) missense probably damaging 1.00
R3154:Trim10 UTSW 17 37,182,580 (GRCm39) missense probably damaging 1.00
R5156:Trim10 UTSW 17 37,187,948 (GRCm39) missense probably damaging 0.99
R5327:Trim10 UTSW 17 37,181,081 (GRCm39) missense probably damaging 1.00
R5361:Trim10 UTSW 17 37,186,328 (GRCm39) missense probably benign 0.03
R5758:Trim10 UTSW 17 37,188,044 (GRCm39) missense possibly damaging 0.80
R5764:Trim10 UTSW 17 37,181,073 (GRCm39) missense probably damaging 0.97
R6032:Trim10 UTSW 17 37,182,606 (GRCm39) missense possibly damaging 0.87
R6032:Trim10 UTSW 17 37,182,606 (GRCm39) missense possibly damaging 0.87
R6179:Trim10 UTSW 17 37,187,923 (GRCm39) missense probably damaging 1.00
R6709:Trim10 UTSW 17 37,183,262 (GRCm39) missense probably damaging 0.99
R7172:Trim10 UTSW 17 37,180,955 (GRCm39) missense possibly damaging 0.78
R7197:Trim10 UTSW 17 37,187,846 (GRCm39) missense probably damaging 1.00
R7390:Trim10 UTSW 17 37,180,773 (GRCm39) start codon destroyed probably null 0.98
R7391:Trim10 UTSW 17 37,180,773 (GRCm39) start codon destroyed probably null 0.98
R7696:Trim10 UTSW 17 37,182,644 (GRCm39) missense probably damaging 1.00
R8830:Trim10 UTSW 17 37,180,846 (GRCm39) missense probably damaging 1.00
R8867:Trim10 UTSW 17 37,181,048 (GRCm39) missense probably benign 0.00
R8970:Trim10 UTSW 17 37,184,168 (GRCm39) missense probably benign 0.00
R9376:Trim10 UTSW 17 37,184,168 (GRCm39) missense probably benign 0.00
R9635:Trim10 UTSW 17 37,187,890 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02