Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03135:Zfp944'

410499

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp944

Ensembl Gene

ENSMUSG00000033972

Gene Name

zinc finger protein 944

Synonyms

6330416L07Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.223) question?

Stock #

IGL03135

Quality Score

Status

Chromosome

Chromosomal Location

22556970-22580381 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 22558737 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 170 (I170T)

Ref Sequence

ENSEMBL: ENSMUSP00000111197 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115535]

AlphaFold

E9PUS4

Predicted Effect

probably benign
Transcript: ENSMUST00000115535
AA Change: I170T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000111197
Gene: ENSMUSG00000033972
AA Change: I170T

Domain	Start	End	E-Value	Type
KRAB	13	76	2.08e-21	SMART
ZnF_C2H2	183	205	1.01e-1	SMART
ZnF_C2H2	211	233	1.07e0	SMART
ZnF_C2H2	239	261	1.95e-3	SMART
ZnF_C2H2	267	289	1.22e-4	SMART
ZnF_C2H2	295	317	2.24e-3	SMART
ZnF_C2H2	323	345	1.82e-3	SMART
ZnF_C2H2	351	373	5.99e-4	SMART
ZnF_C2H2	379	401	4.79e-3	SMART
ZnF_C2H2	407	429	2.99e-4	SMART
ZnF_C2H2	435	457	4.17e-3	SMART
ZnF_C2H2	463	485	1.36e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apmap	A	C	2: 150,429,035 (GRCm39)	M196R	possibly damaging	Het
Arhgap27	T	A	11: 103,229,891 (GRCm39)		probably null	Het
Arl8b	A	C	6: 108,795,506 (GRCm39)	N148T	probably benign	Het
Baz1a	A	G	12: 54,976,375 (GRCm39)	F434L	probably damaging	Het
Birc2	A	G	9: 7,849,722 (GRCm39)		probably benign	Het
Brwd1	C	A	16: 95,822,458 (GRCm39)	R1249I	probably damaging	Het
Cab39l	T	C	14: 59,757,100 (GRCm39)	F161L	probably benign	Het
Ccr8	A	T	9: 119,923,689 (GRCm39)	D268V	possibly damaging	Het
Col25a1	A	T	3: 130,323,332 (GRCm39)		probably benign	Het
Cpn1	A	G	19: 43,974,693 (GRCm39)	L12P	possibly damaging	Het
Dnah6	A	G	6: 73,121,987 (GRCm39)	I1360T	probably benign	Het
Dnajb8	A	G	6: 88,200,013 (GRCm39)	E183G	probably damaging	Het
Dpp8	T	A	9: 64,960,322 (GRCm39)		probably null	Het
Fsd1	C	A	17: 56,297,416 (GRCm39)		probably null	Het
Grina	T	A	15: 76,132,162 (GRCm39)	F28I	possibly damaging	Het
H2-M3	G	A	17: 37,583,324 (GRCm39)	D262N	possibly damaging	Het
Hdgfl3	G	A	7: 81,543,587 (GRCm39)	T188M	probably damaging	Het
Kif18b	A	G	11: 102,805,086 (GRCm39)	I353T	probably damaging	Het
Lrrc41	C	A	4: 115,945,728 (GRCm39)	R148S	probably benign	Het
Lrrc8e	T	A	8: 4,285,776 (GRCm39)	L667Q	probably damaging	Het
Lrrk1	A	G	7: 65,912,638 (GRCm39)	F1641L	probably benign	Het
Naaladl1	A	T	19: 6,162,386 (GRCm39)	T443S	probably benign	Het
Naga	C	A	15: 82,214,942 (GRCm39)	V339F	probably damaging	Het
Nedd4l	A	G	18: 65,338,741 (GRCm39)	K702E	probably damaging	Het
Nwd2	T	A	5: 63,963,338 (GRCm39)	L974H	probably damaging	Het
Parp14	A	G	16: 35,678,381 (GRCm39)	M529T	probably damaging	Het
Parp8	A	G	13: 117,047,478 (GRCm39)	V198A	probably benign	Het
Pcdhb19	A	T	18: 37,631,588 (GRCm39)	H461L	probably benign	Het
Ppp6r1	T	C	7: 4,645,159 (GRCm39)	D236G	possibly damaging	Het
Psg21	T	C	7: 18,388,843 (GRCm39)	D83G	probably benign	Het
Ptpru	A	G	4: 131,546,111 (GRCm39)	C308R	probably damaging	Het
Ralgds	T	A	2: 28,439,100 (GRCm39)	S696T	probably damaging	Het
Rttn	T	A	18: 89,033,274 (GRCm39)	L695Q	probably damaging	Het
Scel	A	T	14: 103,823,950 (GRCm39)	I393F	probably benign	Het
Serpina3j	T	A	12: 104,281,166 (GRCm39)	I113N	probably damaging	Het
Slc4a3	C	A	1: 75,524,579 (GRCm39)		probably benign	Het
Slc6a11	A	T	6: 114,171,570 (GRCm39)		probably null	Het
Slc8a3	C	T	12: 81,249,023 (GRCm39)	V802M	probably damaging	Het
Smarcal1	T	A	1: 72,655,660 (GRCm39)		probably null	Het
Tmprss11c	A	G	5: 86,385,509 (GRCm39)	V308A	probably damaging	Het
Trim10	A	G	17: 37,185,113 (GRCm39)	R279G	possibly damaging	Het
Trim30a	A	G	7: 104,060,348 (GRCm39)	V476A	probably damaging	Het
Trio	T	C	15: 27,832,097 (GRCm39)		probably benign	Het
Urgcp	G	A	11: 5,666,091 (GRCm39)	T749I	possibly damaging	Het
Vmn2r60	A	G	7: 41,786,018 (GRCm39)	I274V	probably benign	Het
Vps11	A	G	9: 44,267,653 (GRCm39)	F40L	probably benign	Het
Ywhab	A	G	2: 163,857,195 (GRCm39)	I157V	probably benign	Het
Zfp638	G	A	6: 83,919,857 (GRCm39)	R485H	probably damaging	Het

Other mutations in Zfp944

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00595:Zfp944	APN	17	22,558,186 (GRCm39)	missense	probably benign	0.10
IGL00917:Zfp944	APN	17	22,558,765 (GRCm39)	missense	probably benign	0.00
IGL01093:Zfp944	APN	17	22,562,615 (GRCm39)	splice site	probably benign
IGL02113:Zfp944	APN	17	22,558,047 (GRCm39)	missense	possibly damaging	0.88
IGL02694:Zfp944	APN	17	22,558,899 (GRCm39)	missense	probably benign	0.05
IGL03172:Zfp944	APN	17	22,559,018 (GRCm39)	missense	probably damaging	0.98
R0121:Zfp944	UTSW	17	22,558,249 (GRCm39)	missense	possibly damaging	0.69
R0336:Zfp944	UTSW	17	22,558,009 (GRCm39)	missense	probably damaging	1.00
R0755:Zfp944	UTSW	17	22,558,889 (GRCm39)	missense	possibly damaging	0.63
R1536:Zfp944	UTSW	17	22,558,697 (GRCm39)	nonsense	probably null
R1708:Zfp944	UTSW	17	22,558,026 (GRCm39)	missense	probably damaging	0.98
R1886:Zfp944	UTSW	17	22,558,960 (GRCm39)	missense	probably benign	0.04
R1928:Zfp944	UTSW	17	22,560,065 (GRCm39)	missense	probably damaging	0.96
R1950:Zfp944	UTSW	17	22,558,681 (GRCm39)	missense	probably benign	0.16
R2075:Zfp944	UTSW	17	22,558,178 (GRCm39)	nonsense	probably null
R2101:Zfp944	UTSW	17	22,558,809 (GRCm39)	missense	probably benign	0.41
R2433:Zfp944	UTSW	17	22,558,193 (GRCm39)	nonsense	probably null
R4698:Zfp944	UTSW	17	22,558,180 (GRCm39)	missense	probably damaging	1.00
R4986:Zfp944	UTSW	17	22,558,211 (GRCm39)	missense	probably damaging	1.00
R6451:Zfp944	UTSW	17	22,557,846 (GRCm39)	missense	probably benign	0.40
R6566:Zfp944	UTSW	17	22,558,726 (GRCm39)	missense	possibly damaging	0.96
R6752:Zfp944	UTSW	17	22,558,500 (GRCm39)	missense	probably benign	0.01
R7064:Zfp944	UTSW	17	22,558,560 (GRCm39)	missense	probably damaging	1.00
R8193:Zfp944	UTSW	17	22,558,861 (GRCm39)	nonsense	probably null
R8323:Zfp944	UTSW	17	22,558,235 (GRCm39)	missense	probably benign
R8328:Zfp944	UTSW	17	22,558,705 (GRCm39)	nonsense	probably null
R8902:Zfp944	UTSW	17	22,558,761 (GRCm39)	missense	probably benign	0.41
R8915:Zfp944	UTSW	17	22,558,507 (GRCm39)	missense	probably benign	0.05
R9130:Zfp944	UTSW	17	22,560,031 (GRCm39)	missense	probably damaging	1.00
R9248:Zfp944	UTSW	17	22,562,619 (GRCm39)	critical splice donor site	probably null

Posted On

2016-08-02