Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03136:Fkbp15'

410553

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fkbp15

Ensembl Gene

ENSMUSG00000066151

Gene Name

FK506 binding protein 15

Synonyms

FKBP133, C430014M02Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03136

Quality Score

Status

Chromosome

Chromosomal Location

62300342-62360548 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 62340229 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000103085 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084527] [ENSMUST00000084528] [ENSMUST00000098033] [ENSMUST00000107461]

Predicted Effect

probably benign
Transcript: ENSMUST00000084527

SMART Domains

Protein: ENSMUSP00000081575
Gene: ENSMUSG00000066151

Domain	Start	End	E-Value	Type
low complexity region	59	68	N/A	INTRINSIC
Pfam:FKBP_C	190	286	4.8e-21	PFAM
low complexity region	302	322	N/A	INTRINSIC
low complexity region	326	338	N/A	INTRINSIC
internal_repeat_1	403	431	1.88e-10	PROSPERO
internal_repeat_1	472	500	1.88e-10	PROSPERO
coiled coil region	560	662	N/A	INTRINSIC
coiled coil region	684	790	N/A	INTRINSIC
coiled coil region	816	865	N/A	INTRINSIC
coiled coil region	916	943	N/A	INTRINSIC
low complexity region	952	964	N/A	INTRINSIC
low complexity region	983	994	N/A	INTRINSIC
low complexity region	1034	1045	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000084528

SMART Domains

Protein: ENSMUSP00000081576
Gene: ENSMUSG00000066151

Domain	Start	End	E-Value	Type
low complexity region	59	68	N/A	INTRINSIC
Pfam:FKBP_C	190	286	2.4e-21	PFAM
low complexity region	302	322	N/A	INTRINSIC
low complexity region	326	338	N/A	INTRINSIC
internal_repeat_1	403	431	2.74e-10	PROSPERO
internal_repeat_1	472	500	2.74e-10	PROSPERO
coiled coil region	560	662	N/A	INTRINSIC
coiled coil region	684	745	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000098033

SMART Domains

Protein: ENSMUSP00000095641
Gene: ENSMUSG00000066151

Domain	Start	End	E-Value	Type
low complexity region	59	68	N/A	INTRINSIC
Pfam:FKBP_C	190	286	1.9e-21	PFAM
low complexity region	302	322	N/A	INTRINSIC
low complexity region	326	338	N/A	INTRINSIC
internal_repeat_1	403	431	1.79e-8	PROSPERO
internal_repeat_1	472	500	1.79e-8	PROSPERO
coiled coil region	560	608	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107461

SMART Domains

Protein: ENSMUSP00000103085
Gene: ENSMUSG00000066151

Domain	Start	End	E-Value	Type
low complexity region	59	68	N/A	INTRINSIC
Pfam:FKBP_C	190	286	2e-21	PFAM
low complexity region	302	322	N/A	INTRINSIC
low complexity region	326	338	N/A	INTRINSIC
internal_repeat_1	403	431	1.86e-8	PROSPERO
internal_repeat_1	472	500	1.86e-8	PROSPERO
coiled coil region	560	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131977

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730522E02Rik	A	G	11: 25,769,122	L7S	unknown	Het
Abr	C	T	11: 76,425,295	W571*	probably null	Het
Adam18	A	T	8: 24,641,836	C420S	probably damaging	Het
Akap5	G	T	12: 76,329,875	E694*	probably null	Het
Bbs1	T	C	19: 4,890,991	K565R	probably benign	Het
Brix1	A	G	15: 10,478,766	F189S	probably damaging	Het
Cnot4	C	A	6: 35,051,241	R480L	probably damaging	Het
Ctu2	A	G	8: 122,479,201		probably benign	Het
Dhcr7	A	G	7: 143,847,366	H422R	probably damaging	Het
Dock1	A	G	7: 135,168,389	M1793V	probably benign	Het
Dock7	A	G	4: 99,003,791	F853L	probably damaging	Het
Ftsj3	C	T	11: 106,253,813	D117N	probably damaging	Het
Gphn	A	G	12: 78,481,333	I142V	possibly damaging	Het
Hsd3b1	G	A	3: 98,852,985	A230V	probably damaging	Het
Hydin	G	A	8: 110,418,524	A836T	probably benign	Het
Ift52	G	T	2: 163,025,334	E71*	probably null	Het
Ms4a14	T	C	19: 11,304,411	D261G	possibly damaging	Het
Nid1	G	A	13: 13,500,499	V935I	probably benign	Het
Nrap	T	C	19: 56,342,255	K1008E	possibly damaging	Het
Nup210	A	C	6: 91,028,861	V1340G	probably benign	Het
Olfr1442	T	A	19: 12,674,967	I254N	probably damaging	Het
Olfr169	A	T	16: 19,566,353	F177I	probably damaging	Het
Olfr974	T	C	9: 39,943,036	Y259H	probably damaging	Het
Pcdhb15	C	A	18: 37,475,014	T433N	probably damaging	Het
Pdcd6ip	T	A	9: 113,691,499	N139I	probably damaging	Het
Pgbd1	A	G	13: 21,433,439	V80A	possibly damaging	Het
Pigw	A	G	11: 84,877,777	I242T	probably benign	Het
Prtg	T	G	9: 72,856,985	V580G	possibly damaging	Het
Ptpn13	T	A	5: 103,543,463	N1065K	possibly damaging	Het
Qrich1	G	A	9: 108,544,918	R577H	probably damaging	Het
Ryr3	G	A	2: 112,675,974		probably benign	Het
Selenoi	T	C	5: 30,257,727	Y197H	probably damaging	Het
Slc47a2	A	G	11: 61,310,765	C343R	probably benign	Het
Smurf2	A	T	11: 106,831,048	D527E	probably benign	Het
Spam1	C	T	6: 24,797,011		probably benign	Het
Stkld1	T	C	2: 26,951,423	V460A	probably benign	Het
Tgoln1	G	A	6: 72,614,113	R339W	probably damaging	Het
Tprg	T	C	16: 25,412,762		probably benign	Het
Treml1	T	G	17: 48,364,851		probably benign	Het
Ttc39b	A	T	4: 83,237,280	V497E	probably damaging	Het
Vmn1r223	A	G	13: 23,249,763	T176A	possibly damaging	Het
Vmn2r75	A	T	7: 86,148,703	I634N	possibly damaging	Het
Vps13c	A	G	9: 67,950,310	E2608G	probably damaging	Het
Zfp575	A	G	7: 24,585,956	C87R	probably damaging	Het
Zfp790	T	A	7: 29,829,895	Y668*	probably null	Het

Other mutations in Fkbp15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00659:Fkbp15	APN	4	62333680	splice site	probably benign
IGL01326:Fkbp15	APN	4	62323250	missense	probably damaging	0.98
IGL01822:Fkbp15	APN	4	62352504	missense	probably benign
IGL01925:Fkbp15	APN	4	62323213	missense	probably damaging	1.00
IGL02190:Fkbp15	APN	4	62304822	missense	possibly damaging	0.69
IGL02276:Fkbp15	APN	4	62336466	nonsense	probably null
IGL02310:Fkbp15	APN	4	62340316	missense	probably damaging	1.00
IGL02954:Fkbp15	APN	4	62321065	splice site	probably benign
IGL02967:Fkbp15	APN	4	62304390	missense	probably damaging	0.96
IGL03185:Fkbp15	APN	4	62332186	splice site	probably null
IGL03280:Fkbp15	APN	4	62303267	unclassified	probably benign
dura	UTSW	4	62324126	missense	probably damaging	0.96
mater	UTSW	4	62326136	missense	probably benign	0.22
R0419:Fkbp15	UTSW	4	62326136	missense	probably benign	0.22
R0838:Fkbp15	UTSW	4	62324126	missense	probably damaging	0.96
R1241:Fkbp15	UTSW	4	62304609	missense	possibly damaging	0.87
R1394:Fkbp15	UTSW	4	62327872	missense	probably benign	0.00
R1622:Fkbp15	UTSW	4	62323202	missense	possibly damaging	0.94
R1682:Fkbp15	UTSW	4	62324194	missense	probably damaging	0.98
R1823:Fkbp15	UTSW	4	62337091	missense	probably damaging	1.00
R1994:Fkbp15	UTSW	4	62304381	missense	probably benign	0.00
R2132:Fkbp15	UTSW	4	62327899	missense	probably damaging	1.00
R2133:Fkbp15	UTSW	4	62327899	missense	probably damaging	1.00
R2425:Fkbp15	UTSW	4	62312365	missense	probably benign	0.00
R2938:Fkbp15	UTSW	4	62304663	missense	probably benign	0.23
R3034:Fkbp15	UTSW	4	62306892	splice site	probably null
R3957:Fkbp15	UTSW	4	62334252	missense	probably benign	0.01
R3963:Fkbp15	UTSW	4	62340677	missense	probably damaging	1.00
R4235:Fkbp15	UTSW	4	62336456	missense	probably benign	0.38
R4334:Fkbp15	UTSW	4	62303219	missense	possibly damaging	0.95
R4366:Fkbp15	UTSW	4	62336414	missense	probably benign	0.38
R4717:Fkbp15	UTSW	4	62308069	missense	probably damaging	1.00
R4790:Fkbp15	UTSW	4	62307997	missense	probably benign	0.05
R5075:Fkbp15	UTSW	4	62321029	missense	probably damaging	0.96
R5176:Fkbp15	UTSW	4	62312323	missense	possibly damaging	0.68
R5419:Fkbp15	UTSW	4	62327877	missense	probably damaging	0.98
R5503:Fkbp15	UTSW	4	62327887	missense	probably benign	0.05
R5731:Fkbp15	UTSW	4	62306929	missense	probably benign	0.01
R5733:Fkbp15	UTSW	4	62306929	missense	probably benign	0.01
R5820:Fkbp15	UTSW	4	62345546	missense	probably benign	0.00
R5878:Fkbp15	UTSW	4	62306908	missense	probably benign
R5898:Fkbp15	UTSW	4	62326057	critical splice donor site	probably null
R5914:Fkbp15	UTSW	4	62327810	splice site	probably null
R6113:Fkbp15	UTSW	4	62340647	missense	probably benign	0.38
R6377:Fkbp15	UTSW	4	62324192	missense	probably damaging	1.00
R6427:Fkbp15	UTSW	4	62323202	missense	probably benign	0.01
R6464:Fkbp15	UTSW	4	62308078	missense	possibly damaging	0.92
R6528:Fkbp15	UTSW	4	62332270	missense	probably damaging	1.00
R6790:Fkbp15	UTSW	4	62304759	missense	probably benign	0.01
R6880:Fkbp15	UTSW	4	62336495	missense	possibly damaging	0.71
R6911:Fkbp15	UTSW	4	62340290	missense	probably damaging	1.00
R7371:Fkbp15	UTSW	4	62321056	missense	possibly damaging	0.89
R7410:Fkbp15	UTSW	4	62340299	missense	probably damaging	1.00
R7660:Fkbp15	UTSW	4	62314341	missense	probably benign	0.08
X0013:Fkbp15	UTSW	4	62312370	missense	probably benign	0.36

Posted On

2016-08-02