Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03137:Ankub1'

410571

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ankub1

Ensembl Gene

ENSMUSG00000074591

Gene Name

ankyrin repeat and ubiquitin domain containing 1

Synonyms

LOC242037, Gm410

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03137

Quality Score

Status

Chromosome

Chromosomal Location

57574843-57599958 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57597778 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 64 (D64G)

Ref Sequence

ENSEMBL: ENSMUSP00000142589 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099091] [ENSMUST00000197088] [ENSMUST00000200665]

AlphaFold

Q3UUE9

Predicted Effect

probably damaging
Transcript: ENSMUST00000099091
AA Change: D64G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000096689
Gene: ENSMUSG00000074591
AA Change: D64G

Domain	Start	End	E-Value	Type
Blast:UBQ	1	78	3e-41	BLAST
SCOP:d1euvb_	1	78	3e-9	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000197088
AA Change: D64G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000142589
Gene: ENSMUSG00000074591
AA Change: D64G

Domain	Start	End	E-Value	Type
Blast:UBQ	1	78	5e-40	BLAST
ANK	191	220	6.7e-2	SMART
Blast:ANK	239	268	5e-12	BLAST
ANK	273	303	2.6e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000200665

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apobec2	C	T	17: 48,730,303 (GRCm39)	W121*	probably null	Het
Arid2	A	G	15: 96,269,199 (GRCm39)	N1104S	probably benign	Het
Bltp1	T	A	3: 37,088,751 (GRCm39)	M569K	probably damaging	Het
Brap	T	C	5: 121,803,156 (GRCm39)		probably benign	Het
Cilp	A	C	9: 65,185,450 (GRCm39)	N515T	probably benign	Het
Cpeb2	T	A	5: 43,419,067 (GRCm39)		probably benign	Het
Creb1	C	T	1: 64,615,374 (GRCm39)	T242I	possibly damaging	Het
Ddx60	T	C	8: 62,441,117 (GRCm39)	V1062A	possibly damaging	Het
Dock8	A	G	19: 25,133,312 (GRCm39)	E1153G	probably benign	Het
Gk5	A	G	9: 96,058,345 (GRCm39)		probably benign	Het
Gm5478	G	T	15: 101,552,817 (GRCm39)	N60K	probably benign	Het
Hmcn2	T	A	2: 31,252,242 (GRCm39)	V904D	probably damaging	Het
Hnmt	T	A	2: 23,938,751 (GRCm39)	H29L	probably damaging	Het
Hsf1	A	G	15: 76,380,649 (GRCm39)		probably benign	Het
Igkv1-122	C	A	6: 67,994,400 (GRCm39)	T96K	probably damaging	Het
Iyd	T	C	10: 3,501,987 (GRCm39)	I211T	probably damaging	Het
Kcnn1	G	T	8: 71,303,381 (GRCm39)	H34N	probably damaging	Het
Krtap5-3	G	T	7: 141,755,946 (GRCm39)		probably benign	Het
Map3k19	C	T	1: 127,752,052 (GRCm39)	R433K	probably benign	Het
Mss51	A	C	14: 20,537,200 (GRCm39)	C89W	probably damaging	Het
Myh9	A	T	15: 77,675,289 (GRCm39)	I276N	probably damaging	Het
Myof	T	C	19: 37,963,337 (GRCm39)	E420G	probably damaging	Het
Nfatc2ip	C	A	7: 125,989,740 (GRCm39)	V215L	possibly damaging	Het
Or10ag52	A	T	2: 87,043,500 (GRCm39)	Y88F	probably benign	Het
Or51m1	T	C	7: 103,578,801 (GRCm39)	M257T	probably benign	Het
Or5d18	G	A	2: 87,864,754 (GRCm39)	A243V	probably benign	Het
Pcdhb4	T	C	18: 37,441,569 (GRCm39)	I293T	probably damaging	Het
Pdcd6ip	A	G	9: 113,486,213 (GRCm39)	S729P	possibly damaging	Het
Pick1	C	A	15: 79,129,501 (GRCm39)	H169N	possibly damaging	Het
Ppp4r4	A	C	12: 103,547,643 (GRCm39)	K212T	probably damaging	Het
Racgap1	A	G	15: 99,526,622 (GRCm39)	S314P	probably damaging	Het
Rasef	C	A	4: 73,652,720 (GRCm39)	E594*	probably null	Het
Ryr3	T	G	2: 112,740,742 (GRCm39)	K522Q	probably benign	Het
Shoc1	G	T	4: 59,094,162 (GRCm39)	F187L	probably benign	Het
Six5	T	C	7: 18,831,072 (GRCm39)		probably benign	Het
Slc26a9	G	T	1: 131,691,615 (GRCm39)	E619D	probably benign	Het
Sqor	A	G	2: 122,649,991 (GRCm39)	I412V	probably benign	Het
Srrt	T	A	5: 137,294,379 (GRCm39)		probably benign	Het
Sult1e1	C	T	5: 87,726,475 (GRCm39)	R213K	probably benign	Het
Tmc2	T	A	2: 130,082,050 (GRCm39)	L411H	probably damaging	Het
Tmem63b	T	A	17: 45,975,921 (GRCm39)	N511Y	probably damaging	Het
Ucp3	T	A	7: 100,131,969 (GRCm39)		probably benign	Het
Vmn1r201	A	T	13: 22,658,974 (GRCm39)	I63F	probably benign	Het
Vps13c	G	T	9: 67,797,662 (GRCm39)	L522F	probably damaging	Het
Wwp1	T	A	4: 19,678,408 (GRCm39)	T3S	probably damaging	Het
Zc3hav1	A	G	6: 38,309,329 (GRCm39)	S498P	probably benign	Het

Other mutations in Ankub1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01660:Ankub1	APN	3	57,597,817 (GRCm39)	missense	possibly damaging	0.93
R0506:Ankub1	UTSW	3	57,597,796 (GRCm39)	missense	probably damaging	0.97
R0892:Ankub1	UTSW	3	57,597,800 (GRCm39)	missense	probably benign	0.24
R2073:Ankub1	UTSW	3	57,599,713 (GRCm39)	missense	possibly damaging	0.68
R2104:Ankub1	UTSW	3	57,580,296 (GRCm39)	nonsense	probably null
R4869:Ankub1	UTSW	3	57,597,751 (GRCm39)	missense	probably damaging	1.00
R5714:Ankub1	UTSW	3	57,580,258 (GRCm39)	missense	probably benign	0.41
R6229:Ankub1	UTSW	3	57,572,528 (GRCm39)	missense	probably benign	0.00
R6929:Ankub1	UTSW	3	57,572,854 (GRCm39)	nonsense	probably null
R7086:Ankub1	UTSW	3	57,597,746 (GRCm39)	missense	probably damaging	0.99
R7200:Ankub1	UTSW	3	57,580,406 (GRCm39)	missense	probably benign	0.00
R7290:Ankub1	UTSW	3	57,580,345 (GRCm39)	missense	probably damaging	1.00
R7305:Ankub1	UTSW	3	57,599,938 (GRCm39)	start gained	probably benign
R7336:Ankub1	UTSW	3	57,573,108 (GRCm39)	missense	probably benign	0.00
R7407:Ankub1	UTSW	3	57,572,624 (GRCm39)	missense	probably benign
R7566:Ankub1	UTSW	3	57,573,039 (GRCm39)	nonsense	probably null
R7569:Ankub1	UTSW	3	57,573,039 (GRCm39)	nonsense	probably null
R7872:Ankub1	UTSW	3	57,572,807 (GRCm39)	missense	probably damaging	1.00
R8177:Ankub1	UTSW	3	57,597,837 (GRCm39)	missense	possibly damaging	0.82
R8734:Ankub1	UTSW	3	57,599,706 (GRCm39)	missense	probably benign	0.15
R8774:Ankub1	UTSW	3	57,597,802 (GRCm39)	missense	probably damaging	1.00
R8774-TAIL:Ankub1	UTSW	3	57,597,802 (GRCm39)	missense	probably damaging	1.00
R8973:Ankub1	UTSW	3	57,572,932 (GRCm39)	missense	possibly damaging	0.94

Posted On

2016-08-02