Incidental Mutation 'IGL03142:Vmn2r121'
ID 410705
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r121
Ensembl Gene ENSMUSG00000072049
Gene Name vomeronasal 2, receptor 121
Synonyms EG625699
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # IGL03142
Quality Score
Status
Chromosome X
Chromosomal Location 123037036-123045607 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 123042635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 174 (D174G)
Ref Sequence ENSEMBL: ENSMUSP00000092067 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094491]
AlphaFold A2BE32
Predicted Effect possibly damaging
Transcript: ENSMUST00000094491
AA Change: D174G

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000092067
Gene: ENSMUSG00000072049
AA Change: D174G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 75 448 3.2e-26 PFAM
Pfam:NCD3G 506 560 2.1e-19 PFAM
Pfam:7tm_3 593 828 3.8e-56 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc88c T C 12: 100,913,457 (GRCm39) S523G probably damaging Het
Ccnb1 A T 13: 100,920,039 (GRCm39) D157E probably damaging Het
Cep43 T A 17: 8,411,041 (GRCm39) S331R probably damaging Het
Cfap70 T C 14: 20,447,283 (GRCm39) T1055A probably damaging Het
Fn1 C A 1: 71,676,455 (GRCm39) R592L probably damaging Het
Frmpd4 T A X: 166,262,479 (GRCm39) D550V possibly damaging Het
Gcm2 A G 13: 41,256,711 (GRCm39) V346A probably benign Het
Gm10112 C T X: 110,209,673 (GRCm39) T4I probably damaging Het
Gm3115 T C 14: 4,084,302 (GRCm38) probably benign Het
Has2 A T 15: 56,545,491 (GRCm39) I37N possibly damaging Het
Hmgn3 A G 9: 83,028,482 (GRCm39) probably benign Het
Klhl29 T A 12: 5,187,603 (GRCm39) N254Y probably damaging Het
Kti12 A G 4: 108,705,362 (GRCm39) Y92C probably damaging Het
Lyset G A 12: 102,710,933 (GRCm39) S52N probably damaging Het
Mgat5 A C 1: 127,339,960 (GRCm39) Q447P probably damaging Het
Mlh3 C A 12: 85,297,075 (GRCm39) probably null Het
Mrpl45 T C 11: 97,206,751 (GRCm39) W18R probably benign Het
Mtor A G 4: 148,538,356 (GRCm39) D138G probably benign Het
Mycbp2 C T 14: 103,536,212 (GRCm39) C246Y probably damaging Het
Mylk4 A T 13: 32,904,582 (GRCm39) V415E probably damaging Het
Olfm3 A T 3: 114,890,679 (GRCm39) Q124L probably damaging Het
Or4d11 A T 19: 12,013,752 (GRCm39) M118K probably damaging Het
Pam C T 1: 97,822,111 (GRCm39) G298R probably damaging Het
Pappa2 A C 1: 158,682,501 (GRCm39) I849R probably damaging Het
Pde3a T A 6: 141,438,025 (GRCm39) D1031E probably benign Het
Pik3cb A T 9: 98,947,615 (GRCm39) S521T probably benign Het
Pkn1 A G 8: 84,397,652 (GRCm39) F824L possibly damaging Het
Pspn C T 17: 57,306,566 (GRCm39) R121Q probably benign Het
Ric1 A G 19: 29,578,380 (GRCm39) D1195G possibly damaging Het
Sin3b A G 8: 73,471,196 (GRCm39) D381G probably damaging Het
Slc37a3 T C 6: 39,336,919 (GRCm39) probably null Het
Smtn T A 11: 3,482,601 (GRCm39) K124* probably null Het
Tbce A G 13: 14,194,449 (GRCm39) V70A possibly damaging Het
Tti1 A G 2: 157,842,597 (GRCm39) Y811H probably damaging Het
Uggt2 T C 14: 119,235,603 (GRCm39) Y1424C probably damaging Het
Upf1 A G 8: 70,785,977 (GRCm39) V994A probably benign Het
Other mutations in Vmn2r121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r121 APN X 123,037,480 (GRCm39) missense possibly damaging 0.95
IGL00990:Vmn2r121 APN X 123,037,499 (GRCm39) missense probably benign 0.04
IGL00990:Vmn2r121 APN X 123,043,413 (GRCm39) missense probably benign 0.00
IGL01125:Vmn2r121 APN X 123,042,504 (GRCm39) missense probably damaging 0.99
IGL01450:Vmn2r121 APN X 123,040,888 (GRCm39) missense possibly damaging 0.57
IGL01619:Vmn2r121 APN X 123,041,997 (GRCm39) missense probably benign
IGL01797:Vmn2r121 APN X 123,041,048 (GRCm39) splice site probably benign
IGL02227:Vmn2r121 APN X 123,042,378 (GRCm39) missense probably benign 0.44
IGL02971:Vmn2r121 APN X 123,037,591 (GRCm39) missense probably damaging 1.00
IGL03058:Vmn2r121 APN X 123,042,618 (GRCm39) missense probably benign 0.00
IGL03183:Vmn2r121 APN X 123,042,023 (GRCm39) missense probably benign 0.03
E0370:Vmn2r121 UTSW X 123,037,617 (GRCm39) missense probably benign 0.01
R0196:Vmn2r121 UTSW X 123,041,879 (GRCm39) missense probably benign 0.03
R1381:Vmn2r121 UTSW X 123,037,837 (GRCm39) missense probably damaging 1.00
R1399:Vmn2r121 UTSW X 123,039,545 (GRCm39) missense possibly damaging 0.94
R1423:Vmn2r121 UTSW X 123,039,602 (GRCm39) missense possibly damaging 0.52
R1687:Vmn2r121 UTSW X 123,042,488 (GRCm39) missense probably benign 0.39
R2121:Vmn2r121 UTSW X 123,043,439 (GRCm39) splice site probably null
R2124:Vmn2r121 UTSW X 123,043,439 (GRCm39) splice site probably null
R3151:Vmn2r121 UTSW X 123,040,849 (GRCm39) missense probably benign 0.20
R4460:Vmn2r121 UTSW X 123,038,281 (GRCm39) missense probably benign 0.01
R4735:Vmn2r121 UTSW X 123,038,335 (GRCm39) missense probably benign
R5332:Vmn2r121 UTSW X 123,043,272 (GRCm39) missense probably benign
R6102:Vmn2r121 UTSW X 123,043,272 (GRCm39) missense probably benign
X0023:Vmn2r121 UTSW X 123,045,354 (GRCm39) missense possibly damaging 0.64
Posted On 2016-08-02