Incidental Mutation 'IGL03142:Hmgn3'
ID 410739
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hmgn3
Ensembl Gene ENSMUSG00000066456
Gene Name high mobility group nucleosomal binding domain 3
Synonyms 6330514M13Rik, HMGN3a, HMGN3b, TRIP7, 1110002A15Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.359) question?
Stock # IGL03142
Quality Score
Status
Chromosome 9
Chromosomal Location 82992001-83028738 bp(-) (GRCm39)
Type of Mutation critical splice donor site
DNA Base Change (assembly) A to G at 83028482 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140247 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161796] [ENSMUST00000162246] [ENSMUST00000185315] [ENSMUST00000187193] [ENSMUST00000190154]
AlphaFold Q9DCB1
Predicted Effect probably benign
Transcript: ENSMUST00000161796
SMART Domains Protein: ENSMUSP00000125616
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 76 3.32e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162246
SMART Domains Protein: ENSMUSP00000124278
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 94 5.21e-40 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000185315
SMART Domains Protein: ENSMUSP00000140356
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 94 1.16e-37 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187193
SMART Domains Protein: ENSMUSP00000140980
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 94 5.5e-40 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187589
Predicted Effect probably benign
Transcript: ENSMUST00000190154
SMART Domains Protein: ENSMUSP00000140247
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 94 1.16e-37 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194148
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit impaired glucose tolerance with decreased insulin serum levels and increased glucose serum levels during feeding. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc88c T C 12: 100,913,457 (GRCm39) S523G probably damaging Het
Ccnb1 A T 13: 100,920,039 (GRCm39) D157E probably damaging Het
Cep43 T A 17: 8,411,041 (GRCm39) S331R probably damaging Het
Cfap70 T C 14: 20,447,283 (GRCm39) T1055A probably damaging Het
Fn1 C A 1: 71,676,455 (GRCm39) R592L probably damaging Het
Frmpd4 T A X: 166,262,479 (GRCm39) D550V possibly damaging Het
Gcm2 A G 13: 41,256,711 (GRCm39) V346A probably benign Het
Gm10112 C T X: 110,209,673 (GRCm39) T4I probably damaging Het
Gm3115 T C 14: 4,084,302 (GRCm38) probably benign Het
Has2 A T 15: 56,545,491 (GRCm39) I37N possibly damaging Het
Klhl29 T A 12: 5,187,603 (GRCm39) N254Y probably damaging Het
Kti12 A G 4: 108,705,362 (GRCm39) Y92C probably damaging Het
Lyset G A 12: 102,710,933 (GRCm39) S52N probably damaging Het
Mgat5 A C 1: 127,339,960 (GRCm39) Q447P probably damaging Het
Mlh3 C A 12: 85,297,075 (GRCm39) probably null Het
Mrpl45 T C 11: 97,206,751 (GRCm39) W18R probably benign Het
Mtor A G 4: 148,538,356 (GRCm39) D138G probably benign Het
Mycbp2 C T 14: 103,536,212 (GRCm39) C246Y probably damaging Het
Mylk4 A T 13: 32,904,582 (GRCm39) V415E probably damaging Het
Olfm3 A T 3: 114,890,679 (GRCm39) Q124L probably damaging Het
Or4d11 A T 19: 12,013,752 (GRCm39) M118K probably damaging Het
Pam C T 1: 97,822,111 (GRCm39) G298R probably damaging Het
Pappa2 A C 1: 158,682,501 (GRCm39) I849R probably damaging Het
Pde3a T A 6: 141,438,025 (GRCm39) D1031E probably benign Het
Pik3cb A T 9: 98,947,615 (GRCm39) S521T probably benign Het
Pkn1 A G 8: 84,397,652 (GRCm39) F824L possibly damaging Het
Pspn C T 17: 57,306,566 (GRCm39) R121Q probably benign Het
Ric1 A G 19: 29,578,380 (GRCm39) D1195G possibly damaging Het
Sin3b A G 8: 73,471,196 (GRCm39) D381G probably damaging Het
Slc37a3 T C 6: 39,336,919 (GRCm39) probably null Het
Smtn T A 11: 3,482,601 (GRCm39) K124* probably null Het
Tbce A G 13: 14,194,449 (GRCm39) V70A possibly damaging Het
Tti1 A G 2: 157,842,597 (GRCm39) Y811H probably damaging Het
Uggt2 T C 14: 119,235,603 (GRCm39) Y1424C probably damaging Het
Upf1 A G 8: 70,785,977 (GRCm39) V994A probably benign Het
Vmn2r121 T C X: 123,042,635 (GRCm39) D174G possibly damaging Het
Other mutations in Hmgn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01810:Hmgn3 APN 9 82,992,437 (GRCm39) utr 3 prime probably benign
R0519:Hmgn3 UTSW 9 82,994,301 (GRCm39) missense probably damaging 1.00
R0601:Hmgn3 UTSW 9 83,028,482 (GRCm39) critical splice donor site probably null
R6008:Hmgn3 UTSW 9 82,994,284 (GRCm39) missense probably damaging 0.99
R8346:Hmgn3 UTSW 9 82,993,159 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02