Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03143:Ceacam3'

410744

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ceacam3

Ensembl Gene

ENSMUSG00000053228

Gene Name

CEA cell adhesion molecule 3

Synonyms

EG384557, cea12, Psg24

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03143

Quality Score

Status

Chromosome

Chromosomal Location

16884207-16898178 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 16892045 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Stop codon at position 263 (E263*)

Ref Sequence

ENSEMBL: ENSMUSP00000104131 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108491]

AlphaFold

E9Q6J4

Predicted Effect

probably null
Transcript: ENSMUST00000108491
AA Change: E263*

SMART Domains

Protein: ENSMUSP00000104131
Gene: ENSMUSG00000053228
AA Change: E263*

Domain	Start	End	E-Value	Type
IG	40	141	2.83e-3	SMART
IG	160	261	6.31e-1	SMART
IG	280	379	8.01e-3	SMART
IG	398	497	2.08e-1	SMART
IG	514	613	1.26e0	SMART
IGc2	631	695	7.64e-9	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr2	T	G	9: 121,738,333 (GRCm39)	L236R	probably damaging	Het
Agbl1	C	T	7: 76,069,793 (GRCm39)	Q442*	probably null	Het
Ahrr	G	A	13: 74,405,614 (GRCm39)	Q108*	probably null	Het
Ankrd23	T	C	1: 36,570,726 (GRCm39)		probably benign	Het
Art5	A	G	7: 101,747,104 (GRCm39)	I225T	probably damaging	Het
Asxl3	T	C	18: 22,656,031 (GRCm39)	V1347A	probably benign	Het
Birc6	A	G	17: 74,905,994 (GRCm39)	M1326V	possibly damaging	Het
Bpifb6	A	C	2: 153,744,655 (GRCm39)	N32T	probably damaging	Het
Brip1	T	A	11: 85,952,653 (GRCm39)	T1043S	possibly damaging	Het
Cbx5	A	T	15: 103,121,532 (GRCm39)	V35E	probably damaging	Het
Ccdc175	T	A	12: 72,182,832 (GRCm39)	M396L	probably benign	Het
Cyp4a12a	A	G	4: 115,159,200 (GRCm39)	T157A	probably benign	Het
Dennd11	A	T	6: 40,399,828 (GRCm39)		probably benign	Het
Derl3	T	C	10: 75,730,324 (GRCm39)	V129A	possibly damaging	Het
Dnajb1	T	C	8: 84,335,103 (GRCm39)	I48T	probably damaging	Het
Dop1b	G	A	16: 93,556,543 (GRCm39)	E349K	probably benign	Het
Fkbp10	A	T	11: 100,313,580 (GRCm39)	I285F	probably benign	Het
Frrs1	A	T	3: 116,692,836 (GRCm39)	T37S	probably damaging	Het
Gata2	A	G	6: 88,181,677 (GRCm39)	Y377C	probably damaging	Het
Gm9789	T	A	16: 88,954,883 (GRCm39)		probably benign	Het
Itpkb	T	A	1: 180,160,933 (GRCm39)	V353D	probably benign	Het
Kcng4	T	C	8: 120,352,509 (GRCm39)	E467G	probably damaging	Het
Kdm3a	A	T	6: 71,573,845 (GRCm39)	I906N	probably damaging	Het
Lama1	G	A	17: 68,111,531 (GRCm39)	G2261R	probably damaging	Het
Lamc1	A	T	1: 153,208,020 (GRCm39)	L89Q	probably benign	Het
Lef1	G	T	3: 130,993,965 (GRCm39)	E314*	probably null	Het
Lpin3	T	C	2: 160,745,518 (GRCm39)		probably benign	Het
Mrtfb	A	G	16: 13,218,676 (GRCm39)	N452D	possibly damaging	Het
Naaladl1	C	T	19: 6,164,896 (GRCm39)	T628I	possibly damaging	Het
Nell1	C	T	7: 49,929,281 (GRCm39)	Q259*	probably null	Het
Neu2	G	T	1: 87,524,698 (GRCm39)	E228*	probably null	Het
Or5b119	A	T	19: 13,456,835 (GRCm39)	H242Q	probably damaging	Het
Or5k15	A	G	16: 58,709,824 (GRCm39)	F253S	probably damaging	Het
Or8g21	T	G	9: 38,906,732 (GRCm39)		probably benign	Het
Or8k20	T	C	2: 86,106,580 (GRCm39)	N84D	probably benign	Het
Osbpl6	T	A	2: 76,378,716 (GRCm39)	D124E	probably damaging	Het
Palm	T	C	10: 79,652,617 (GRCm39)		probably benign	Het
Parp8	C	A	13: 117,047,497 (GRCm39)		probably benign	Het
Pax7	A	G	4: 139,556,798 (GRCm39)		probably benign	Het
Pcnx3	G	A	19: 5,735,423 (GRCm39)	R468W	probably damaging	Het
Pds5b	T	A	5: 150,702,722 (GRCm39)	V818D	probably damaging	Het
Piezo2	C	T	18: 63,241,147 (GRCm39)	V694I	probably damaging	Het
Plk1	A	G	7: 121,760,877 (GRCm39)		probably benign	Het
Polb	T	C	8: 23,130,367 (GRCm39)		probably benign	Het
Rad54b	A	G	4: 11,599,755 (GRCm39)	T320A	probably damaging	Het
Reg3b	G	A	6: 78,349,183 (GRCm39)	W103*	probably null	Het
Slc17a3	T	G	13: 24,039,962 (GRCm39)		probably null	Het
Snrnp200	C	T	2: 127,071,962 (GRCm39)		probably benign	Het
Stox2	T	A	8: 47,646,839 (GRCm39)	H207L	possibly damaging	Het
Tbx15	A	C	3: 99,259,514 (GRCm39)	M462L	possibly damaging	Het
Tcirg1	G	A	19: 3,948,811 (GRCm39)	T458I	probably damaging	Het
Tnfrsf25	A	G	4: 152,201,384 (GRCm39)		probably benign	Het
Trank1	A	G	9: 111,195,155 (GRCm39)	K1060E	probably damaging	Het
Ttc16	T	C	2: 32,664,457 (GRCm39)	D3G	possibly damaging	Het
Vmn1r199	A	C	13: 22,567,299 (GRCm39)	N155H	probably damaging	Het
Vmn1r202	G	A	13: 22,685,640 (GRCm39)	T259I	probably benign	Het

Other mutations in Ceacam3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01161:Ceacam3	APN	7	16,885,782 (GRCm39)	missense	probably benign	0.03
IGL01510:Ceacam3	APN	7	16,893,767 (GRCm39)	missense	probably benign	0.00
IGL01830:Ceacam3	APN	7	16,888,925 (GRCm39)	missense	possibly damaging	0.79
IGL02155:Ceacam3	APN	7	16,896,906 (GRCm39)	missense	possibly damaging	0.58
IGL02281:Ceacam3	APN	7	16,895,656 (GRCm39)	missense	probably benign	0.43
IGL02301:Ceacam3	APN	7	16,897,026 (GRCm39)	missense	probably damaging	1.00
IGL02320:Ceacam3	APN	7	16,895,865 (GRCm39)	missense	probably benign	0.43
IGL02514:Ceacam3	APN	7	16,896,906 (GRCm39)	missense	possibly damaging	0.58
IGL02929:Ceacam3	APN	7	16,892,115 (GRCm39)	missense	probably damaging	1.00
IGL03269:Ceacam3	APN	7	16,895,767 (GRCm39)	missense	probably damaging	0.99
R0408:Ceacam3	UTSW	7	16,885,808 (GRCm39)	critical splice donor site	probably benign
R0591:Ceacam3	UTSW	7	16,885,808 (GRCm39)	critical splice donor site	probably null
R1274:Ceacam3	UTSW	7	16,897,064 (GRCm39)	missense	probably damaging	0.98
R1376:Ceacam3	UTSW	7	16,897,088 (GRCm39)	missense	probably damaging	1.00
R1376:Ceacam3	UTSW	7	16,897,088 (GRCm39)	missense	probably damaging	1.00
R1490:Ceacam3	UTSW	7	16,897,071 (GRCm39)	missense	probably damaging	1.00
R1635:Ceacam3	UTSW	7	16,893,902 (GRCm39)	missense	probably damaging	1.00
R1769:Ceacam3	UTSW	7	16,892,301 (GRCm39)	missense	probably damaging	1.00
R2345:Ceacam3	UTSW	7	16,888,925 (GRCm39)	missense	possibly damaging	0.79
R2367:Ceacam3	UTSW	7	16,885,813 (GRCm39)	splice site	probably null
R2403:Ceacam3	UTSW	7	16,895,779 (GRCm39)	missense	probably damaging	1.00
R4030:Ceacam3	UTSW	7	16,892,267 (GRCm39)	missense	probably benign	0.43
R4240:Ceacam3	UTSW	7	16,893,949 (GRCm39)	missense	possibly damaging	0.95
R5305:Ceacam3	UTSW	7	16,885,501 (GRCm39)	missense	probably damaging	1.00
R5314:Ceacam3	UTSW	7	16,892,296 (GRCm39)	missense	possibly damaging	0.94
R5433:Ceacam3	UTSW	7	16,893,808 (GRCm39)	missense	possibly damaging	0.48
R5538:Ceacam3	UTSW	7	16,892,346 (GRCm39)	missense	probably damaging	1.00
R5638:Ceacam3	UTSW	7	16,893,860 (GRCm39)	missense	probably damaging	0.98
R5787:Ceacam3	UTSW	7	16,888,971 (GRCm39)	missense	possibly damaging	0.80
R5891:Ceacam3	UTSW	7	16,885,718 (GRCm39)	missense	probably damaging	1.00
R5918:Ceacam3	UTSW	7	16,893,670 (GRCm39)	missense	probably damaging	0.99
R6074:Ceacam3	UTSW	7	16,885,484 (GRCm39)	missense	probably benign	0.05
R6386:Ceacam3	UTSW	7	16,892,144 (GRCm39)	missense	probably benign	0.22
R6439:Ceacam3	UTSW	7	16,892,253 (GRCm39)	missense	possibly damaging	0.59
R6455:Ceacam3	UTSW	7	16,895,863 (GRCm39)	missense	possibly damaging	0.81
R7150:Ceacam3	UTSW	7	16,885,487 (GRCm39)	missense
R7196:Ceacam3	UTSW	7	16,888,881 (GRCm39)	missense
R7201:Ceacam3	UTSW	7	16,892,163 (GRCm39)	nonsense	probably null
R7731:Ceacam3	UTSW	7	16,892,275 (GRCm39)	missense
R7833:Ceacam3	UTSW	7	16,893,778 (GRCm39)	missense
R8202:Ceacam3	UTSW	7	16,896,953 (GRCm39)	missense
R8237:Ceacam3	UTSW	7	16,897,082 (GRCm39)	missense
R8420:Ceacam3	UTSW	7	16,895,608 (GRCm39)	missense
R8696:Ceacam3	UTSW	7	16,893,937 (GRCm39)	missense
R9381:Ceacam3	UTSW	7	16,893,715 (GRCm39)	missense
R9616:Ceacam3	UTSW	7	16,892,078 (GRCm39)	missense
R9633:Ceacam3	UTSW	7	16,895,688 (GRCm39)	missense
R9686:Ceacam3	UTSW	7	16,892,123 (GRCm39)	missense
R9727:Ceacam3	UTSW	7	16,892,262 (GRCm39)	missense

Posted On

2016-08-02