Incidental Mutation 'IGL03143:Rad54b'
| ID |
410756 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Rad54b
|
| Ensembl Gene |
ENSMUSG00000078773 |
| Gene Name |
RAD54 homolog B (S. cerevisiae) |
| Synonyms |
E130016E03Rik, E130016E03Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03143
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
11558930-11615806 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 11599755 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 320
(T320A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000066977
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000070755]
|
| AlphaFold |
Q6PFE3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000070755
AA Change: T320A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000066977
Gene: ENSMUSG00000078773
AA Change: T320A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
113 |
121 |
N/A |
INTRINSIC |
|
low complexity region
|
164 |
178 |
N/A |
INTRINSIC |
|
DEXDc
|
270 |
470 |
4.36e-36 |
SMART |
|
HELICc
|
652 |
736 |
6.14e-22 |
SMART |
|
| Predicted Effect |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000179731
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene have an increased sensitivity to ionizing radiation and other agents of DNA damage but outherwise have a normal phenotype. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ackr2 |
T |
G |
9: 121,738,333 (GRCm39) |
L236R |
probably damaging |
Het |
| Agbl1 |
C |
T |
7: 76,069,793 (GRCm39) |
Q442* |
probably null |
Het |
| Ahrr |
G |
A |
13: 74,405,614 (GRCm39) |
Q108* |
probably null |
Het |
| Ankrd23 |
T |
C |
1: 36,570,726 (GRCm39) |
|
probably benign |
Het |
| Art5 |
A |
G |
7: 101,747,104 (GRCm39) |
I225T |
probably damaging |
Het |
| Asxl3 |
T |
C |
18: 22,656,031 (GRCm39) |
V1347A |
probably benign |
Het |
| Birc6 |
A |
G |
17: 74,905,994 (GRCm39) |
M1326V |
possibly damaging |
Het |
| Bpifb6 |
A |
C |
2: 153,744,655 (GRCm39) |
N32T |
probably damaging |
Het |
| Brip1 |
T |
A |
11: 85,952,653 (GRCm39) |
T1043S |
possibly damaging |
Het |
| Cbx5 |
A |
T |
15: 103,121,532 (GRCm39) |
V35E |
probably damaging |
Het |
| Ccdc175 |
T |
A |
12: 72,182,832 (GRCm39) |
M396L |
probably benign |
Het |
| Ceacam3 |
G |
T |
7: 16,892,045 (GRCm39) |
E263* |
probably null |
Het |
| Cyp4a12a |
A |
G |
4: 115,159,200 (GRCm39) |
T157A |
probably benign |
Het |
| Dennd11 |
A |
T |
6: 40,399,828 (GRCm39) |
|
probably benign |
Het |
| Derl3 |
T |
C |
10: 75,730,324 (GRCm39) |
V129A |
possibly damaging |
Het |
| Dnajb1 |
T |
C |
8: 84,335,103 (GRCm39) |
I48T |
probably damaging |
Het |
| Dop1b |
G |
A |
16: 93,556,543 (GRCm39) |
E349K |
probably benign |
Het |
| Fkbp10 |
A |
T |
11: 100,313,580 (GRCm39) |
I285F |
probably benign |
Het |
| Frrs1 |
A |
T |
3: 116,692,836 (GRCm39) |
T37S |
probably damaging |
Het |
| Gata2 |
A |
G |
6: 88,181,677 (GRCm39) |
Y377C |
probably damaging |
Het |
| Gm9789 |
T |
A |
16: 88,954,883 (GRCm39) |
|
probably benign |
Het |
| Itpkb |
T |
A |
1: 180,160,933 (GRCm39) |
V353D |
probably benign |
Het |
| Kcng4 |
T |
C |
8: 120,352,509 (GRCm39) |
E467G |
probably damaging |
Het |
| Kdm3a |
A |
T |
6: 71,573,845 (GRCm39) |
I906N |
probably damaging |
Het |
| Lama1 |
G |
A |
17: 68,111,531 (GRCm39) |
G2261R |
probably damaging |
Het |
| Lamc1 |
A |
T |
1: 153,208,020 (GRCm39) |
L89Q |
probably benign |
Het |
| Lef1 |
G |
T |
3: 130,993,965 (GRCm39) |
E314* |
probably null |
Het |
| Lpin3 |
T |
C |
2: 160,745,518 (GRCm39) |
|
probably benign |
Het |
| Mrtfb |
A |
G |
16: 13,218,676 (GRCm39) |
N452D |
possibly damaging |
Het |
| Naaladl1 |
C |
T |
19: 6,164,896 (GRCm39) |
T628I |
possibly damaging |
Het |
| Nell1 |
C |
T |
7: 49,929,281 (GRCm39) |
Q259* |
probably null |
Het |
| Neu2 |
G |
T |
1: 87,524,698 (GRCm39) |
E228* |
probably null |
Het |
| Or5b119 |
A |
T |
19: 13,456,835 (GRCm39) |
H242Q |
probably damaging |
Het |
| Or5k15 |
A |
G |
16: 58,709,824 (GRCm39) |
F253S |
probably damaging |
Het |
| Or8g21 |
T |
G |
9: 38,906,732 (GRCm39) |
|
probably benign |
Het |
| Or8k20 |
T |
C |
2: 86,106,580 (GRCm39) |
N84D |
probably benign |
Het |
| Osbpl6 |
T |
A |
2: 76,378,716 (GRCm39) |
D124E |
probably damaging |
Het |
| Palm |
T |
C |
10: 79,652,617 (GRCm39) |
|
probably benign |
Het |
| Parp8 |
C |
A |
13: 117,047,497 (GRCm39) |
|
probably benign |
Het |
| Pax7 |
A |
G |
4: 139,556,798 (GRCm39) |
|
probably benign |
Het |
| Pcnx3 |
G |
A |
19: 5,735,423 (GRCm39) |
R468W |
probably damaging |
Het |
| Pds5b |
T |
A |
5: 150,702,722 (GRCm39) |
V818D |
probably damaging |
Het |
| Piezo2 |
C |
T |
18: 63,241,147 (GRCm39) |
V694I |
probably damaging |
Het |
| Plk1 |
A |
G |
7: 121,760,877 (GRCm39) |
|
probably benign |
Het |
| Polb |
T |
C |
8: 23,130,367 (GRCm39) |
|
probably benign |
Het |
| Reg3b |
G |
A |
6: 78,349,183 (GRCm39) |
W103* |
probably null |
Het |
| Slc17a3 |
T |
G |
13: 24,039,962 (GRCm39) |
|
probably null |
Het |
| Snrnp200 |
C |
T |
2: 127,071,962 (GRCm39) |
|
probably benign |
Het |
| Stox2 |
T |
A |
8: 47,646,839 (GRCm39) |
H207L |
possibly damaging |
Het |
| Tbx15 |
A |
C |
3: 99,259,514 (GRCm39) |
M462L |
possibly damaging |
Het |
| Tcirg1 |
G |
A |
19: 3,948,811 (GRCm39) |
T458I |
probably damaging |
Het |
| Tnfrsf25 |
A |
G |
4: 152,201,384 (GRCm39) |
|
probably benign |
Het |
| Trank1 |
A |
G |
9: 111,195,155 (GRCm39) |
K1060E |
probably damaging |
Het |
| Ttc16 |
T |
C |
2: 32,664,457 (GRCm39) |
D3G |
possibly damaging |
Het |
| Vmn1r199 |
A |
C |
13: 22,567,299 (GRCm39) |
N155H |
probably damaging |
Het |
| Vmn1r202 |
G |
A |
13: 22,685,640 (GRCm39) |
T259I |
probably benign |
Het |
|
| Other mutations in Rad54b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00770:Rad54b
|
APN |
4 |
11,593,765 (GRCm39) |
missense |
probably benign |
|
|
IGL00774:Rad54b
|
APN |
4 |
11,593,765 (GRCm39) |
missense |
probably benign |
|
|
IGL00956:Rad54b
|
APN |
4 |
11,597,833 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00961:Rad54b
|
APN |
4 |
11,599,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01064:Rad54b
|
APN |
4 |
11,604,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02150:Rad54b
|
APN |
4 |
11,610,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02326:Rad54b
|
APN |
4 |
11,612,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03105:Rad54b
|
APN |
4 |
11,615,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03288:Rad54b
|
APN |
4 |
11,569,833 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
kerplunk
|
UTSW |
4 |
11,612,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Schnipfel
|
UTSW |
4 |
11,583,689 (GRCm39) |
unclassified |
probably benign |
|
|
P0033:Rad54b
|
UTSW |
4 |
11,609,285 (GRCm39) |
unclassified |
probably benign |
|
|
R0076:Rad54b
|
UTSW |
4 |
11,609,480 (GRCm39) |
unclassified |
probably benign |
|
|
R0094:Rad54b
|
UTSW |
4 |
11,599,681 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0391:Rad54b
|
UTSW |
4 |
11,601,702 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0441:Rad54b
|
UTSW |
4 |
11,563,394 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0442:Rad54b
|
UTSW |
4 |
11,610,362 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0442:Rad54b
|
UTSW |
4 |
11,609,480 (GRCm39) |
unclassified |
probably benign |
|
|
R0449:Rad54b
|
UTSW |
4 |
11,606,131 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0519:Rad54b
|
UTSW |
4 |
11,599,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0843:Rad54b
|
UTSW |
4 |
11,609,471 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1118:Rad54b
|
UTSW |
4 |
11,563,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1439:Rad54b
|
UTSW |
4 |
11,606,152 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1763:Rad54b
|
UTSW |
4 |
11,604,989 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1812:Rad54b
|
UTSW |
4 |
11,612,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Rad54b
|
UTSW |
4 |
11,601,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1917:Rad54b
|
UTSW |
4 |
11,601,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1918:Rad54b
|
UTSW |
4 |
11,601,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1919:Rad54b
|
UTSW |
4 |
11,601,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2057:Rad54b
|
UTSW |
4 |
11,606,088 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2386:Rad54b
|
UTSW |
4 |
11,597,874 (GRCm39) |
missense |
probably benign |
|
|
R2437:Rad54b
|
UTSW |
4 |
11,606,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4299:Rad54b
|
UTSW |
4 |
11,597,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4391:Rad54b
|
UTSW |
4 |
11,615,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4672:Rad54b
|
UTSW |
4 |
11,609,449 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4673:Rad54b
|
UTSW |
4 |
11,609,449 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4826:Rad54b
|
UTSW |
4 |
11,599,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4930:Rad54b
|
UTSW |
4 |
11,615,579 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5796:Rad54b
|
UTSW |
4 |
11,615,446 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5901:Rad54b
|
UTSW |
4 |
11,595,919 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6185:Rad54b
|
UTSW |
4 |
11,593,804 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6355:Rad54b
|
UTSW |
4 |
11,604,989 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6576:Rad54b
|
UTSW |
4 |
11,601,577 (GRCm39) |
missense |
probably benign |
|
|
R6684:Rad54b
|
UTSW |
4 |
11,583,689 (GRCm39) |
unclassified |
probably benign |
|
|
R6821:Rad54b
|
UTSW |
4 |
11,612,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6947:Rad54b
|
UTSW |
4 |
11,569,859 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7177:Rad54b
|
UTSW |
4 |
11,599,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Rad54b
|
UTSW |
4 |
11,599,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Rad54b
|
UTSW |
4 |
11,610,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7511:Rad54b
|
UTSW |
4 |
11,578,956 (GRCm39) |
splice site |
probably null |
|
|
R7847:Rad54b
|
UTSW |
4 |
11,612,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7908:Rad54b
|
UTSW |
4 |
11,595,868 (GRCm39) |
missense |
probably null |
0.01 |
|
R8198:Rad54b
|
UTSW |
4 |
11,612,440 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9140:Rad54b
|
UTSW |
4 |
11,610,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9213:Rad54b
|
UTSW |
4 |
11,609,321 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation