Incidental Mutation 'IGL03143:Trank1'
ID 410762
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trank1
Ensembl Gene ENSMUSG00000062296
Gene Name tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Accession Numbers

Genbank: NM_001164659.1; Ensembl: ENSMUST00000078626

Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03143
Quality Score
Status
Chromosome 9
Chromosomal Location 111311739-111395775 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111366087 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 1060 (K1060E)
Ref Sequence ENSEMBL: ENSMUSP00000077697 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078626]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000078626
AA Change: K1060E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077697
Gene: ENSMUSG00000062296
AA Change: K1060E

DomainStartEndE-ValueType
low complexity region 4 30 N/A INTRINSIC
low complexity region 34 52 N/A INTRINSIC
low complexity region 113 129 N/A INTRINSIC
Blast:TPR 144 177 1e-15 BLAST
Blast:TPR 178 209 8e-13 BLAST
Blast:ANK 332 361 1e-6 BLAST
ANK 369 405 5.29e0 SMART
ANK 538 567 2.11e2 SMART
ANK 572 609 7.29e2 SMART
ANK 621 652 1.21e2 SMART
low complexity region 887 895 N/A INTRINSIC
low complexity region 1152 1172 N/A INTRINSIC
Blast:AAA 1351 1569 1e-6 BLAST
low complexity region 2166 2177 N/A INTRINSIC
low complexity region 2395 2411 N/A INTRINSIC
low complexity region 2636 2649 N/A INTRINSIC
low complexity region 2966 2983 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ackr2 T G 9: 121,909,267 (GRCm38) L236R probably damaging Het
Agbl1 C T 7: 76,420,045 (GRCm38) Q442* probably null Het
Ahrr G A 13: 74,257,495 (GRCm38) Q108* probably null Het
Ankrd23 T C 1: 36,531,645 (GRCm38) probably benign Het
Art5 A G 7: 102,097,897 (GRCm38) I225T probably damaging Het
Asxl3 T C 18: 22,522,974 (GRCm38) V1347A probably benign Het
Birc6 A G 17: 74,598,999 (GRCm38) M1326V possibly damaging Het
Bpifb6 A C 2: 153,902,735 (GRCm38) N32T probably damaging Het
Brip1 T A 11: 86,061,827 (GRCm38) T1043S possibly damaging Het
Cbx5 A T 15: 103,213,105 (GRCm38) V35E probably damaging Het
Ccdc175 T A 12: 72,136,058 (GRCm38) M396L probably benign Het
Ceacam3 G T 7: 17,158,120 (GRCm38) E263* probably null Het
Cyp4a12a A G 4: 115,302,003 (GRCm38) T157A probably benign Het
Derl3 T C 10: 75,894,490 (GRCm38) V129A possibly damaging Het
Dnajb1 T C 8: 83,608,474 (GRCm38) I48T probably damaging Het
Dopey2 G A 16: 93,759,655 (GRCm38) E349K probably benign Het
E330009J07Rik A T 6: 40,422,894 (GRCm38) probably benign Het
Fkbp10 A T 11: 100,422,754 (GRCm38) I285F probably benign Het
Frrs1 A T 3: 116,899,187 (GRCm38) T37S probably damaging Het
Gata2 A G 6: 88,204,695 (GRCm38) Y377C probably damaging Het
Gm9789 T A 16: 89,157,995 (GRCm38) probably benign Het
Itpkb T A 1: 180,333,368 (GRCm38) V353D probably benign Het
Kcng4 T C 8: 119,625,770 (GRCm38) E467G probably damaging Het
Kdm3a A T 6: 71,596,861 (GRCm38) I906N probably damaging Het
Lama1 G A 17: 67,804,536 (GRCm38) G2261R probably damaging Het
Lamc1 A T 1: 153,332,274 (GRCm38) L89Q probably benign Het
Lef1 G T 3: 131,200,316 (GRCm38) E314* probably null Het
Lpin3 T C 2: 160,903,598 (GRCm38) probably benign Het
Mkl2 A G 16: 13,400,812 (GRCm38) N452D possibly damaging Het
Naaladl1 C T 19: 6,114,866 (GRCm38) T628I possibly damaging Het
Nell1 C T 7: 50,279,533 (GRCm38) Q259* probably null Het
Neu2 G T 1: 87,596,976 (GRCm38) E228* probably null Het
Olfr1051 T C 2: 86,276,236 (GRCm38) N84D probably benign Het
Olfr1475 A T 19: 13,479,471 (GRCm38) H242Q probably damaging Het
Olfr178 A G 16: 58,889,461 (GRCm38) F253S probably damaging Het
Olfr935 T G 9: 38,995,436 (GRCm38) probably benign Het
Osbpl6 T A 2: 76,548,372 (GRCm38) D124E probably damaging Het
Palm T C 10: 79,816,783 (GRCm38) probably benign Het
Parp8 C A 13: 116,910,961 (GRCm38) probably benign Het
Pax7 A G 4: 139,829,487 (GRCm38) probably benign Het
Pcnx3 G A 19: 5,685,395 (GRCm38) R468W probably damaging Het
Pds5b T A 5: 150,779,257 (GRCm38) V818D probably damaging Het
Piezo2 C T 18: 63,108,076 (GRCm38) V694I probably damaging Het
Plk1 A G 7: 122,161,654 (GRCm38) probably benign Het
Polb T C 8: 22,640,351 (GRCm38) probably benign Het
Rad54b A G 4: 11,599,755 (GRCm38) T320A probably damaging Het
Reg3b G A 6: 78,372,200 (GRCm38) W103* probably null Het
Slc17a3 T G 13: 23,855,979 (GRCm38) probably null Het
Snrnp200 C T 2: 127,230,042 (GRCm38) probably benign Het
Stox2 T A 8: 47,193,804 (GRCm38) H207L possibly damaging Het
Tbx15 A C 3: 99,352,198 (GRCm38) M462L possibly damaging Het
Tcirg1 G A 19: 3,898,811 (GRCm38) T458I probably damaging Het
Tnfrsf25 A G 4: 152,116,927 (GRCm38) probably benign Het
Ttc16 T C 2: 32,774,445 (GRCm38) D3G possibly damaging Het
Vmn1r199 A C 13: 22,383,129 (GRCm38) N155H probably damaging Het
Vmn1r202 G A 13: 22,501,470 (GRCm38) T259I probably benign Het
Other mutations in Trank1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00234:Trank1 APN 9 111,392,609 (GRCm38) missense probably damaging 1.00
IGL00467:Trank1 APN 9 111,364,666 (GRCm38) splice site probably benign
IGL00569:Trank1 APN 9 111,345,511 (GRCm38) missense possibly damaging 0.69
IGL00585:Trank1 APN 9 111,349,290 (GRCm38) missense possibly damaging 0.82
IGL01070:Trank1 APN 9 111,366,793 (GRCm38) missense probably damaging 1.00
IGL01134:Trank1 APN 9 111,391,781 (GRCm38) missense probably benign
IGL01154:Trank1 APN 9 111,386,400 (GRCm38) missense probably benign 0.00
IGL01355:Trank1 APN 9 111,365,520 (GRCm38) missense possibly damaging 0.94
IGL01407:Trank1 APN 9 111,364,722 (GRCm38) missense probably damaging 0.99
IGL01410:Trank1 APN 9 111,365,049 (GRCm38) missense probably benign 0.00
IGL01410:Trank1 APN 9 111,365,259 (GRCm38) missense probably benign 0.00
IGL01504:Trank1 APN 9 111,373,544 (GRCm38) missense probably damaging 1.00
IGL01744:Trank1 APN 9 111,349,363 (GRCm38) missense probably damaging 1.00
IGL02043:Trank1 APN 9 111,363,960 (GRCm38) missense probably damaging 0.98
IGL02104:Trank1 APN 9 111,390,712 (GRCm38) missense possibly damaging 0.85
IGL02193:Trank1 APN 9 111,367,276 (GRCm38) missense probably benign 0.43
IGL02581:Trank1 APN 9 111,383,125 (GRCm38) missense probably benign 0.00
IGL02630:Trank1 APN 9 111,373,075 (GRCm38) missense possibly damaging 0.70
IGL02839:Trank1 APN 9 111,364,756 (GRCm38) missense probably damaging 1.00
IGL02897:Trank1 APN 9 111,367,517 (GRCm38) missense probably damaging 0.99
IGL03065:Trank1 APN 9 111,390,293 (GRCm38) missense possibly damaging 0.64
IGL03123:Trank1 APN 9 111,367,407 (GRCm38) missense probably damaging 1.00
IGL03323:Trank1 APN 9 111,352,116 (GRCm38) missense probably damaging 1.00
1mM(1):Trank1 UTSW 9 111,392,981 (GRCm38) missense probably damaging 1.00
PIT4486001:Trank1 UTSW 9 111,390,107 (GRCm38) missense probably damaging 1.00
PIT4812001:Trank1 UTSW 9 111,347,912 (GRCm38) missense probably damaging 1.00
R0035:Trank1 UTSW 9 111,366,776 (GRCm38) missense probably benign 0.00
R0064:Trank1 UTSW 9 111,343,195 (GRCm38) missense probably damaging 1.00
R0064:Trank1 UTSW 9 111,343,195 (GRCm38) missense probably damaging 1.00
R0089:Trank1 UTSW 9 111,392,910 (GRCm38) missense probably benign 0.00
R0207:Trank1 UTSW 9 111,366,253 (GRCm38) missense probably damaging 1.00
R0255:Trank1 UTSW 9 111,366,024 (GRCm38) missense possibly damaging 0.92
R0334:Trank1 UTSW 9 111,392,940 (GRCm38) missense probably damaging 1.00
R0334:Trank1 UTSW 9 111,365,353 (GRCm38) missense probably benign 0.00
R0383:Trank1 UTSW 9 111,391,477 (GRCm38) missense probably benign 0.08
R0421:Trank1 UTSW 9 111,391,839 (GRCm38) missense probably damaging 1.00
R0494:Trank1 UTSW 9 111,391,293 (GRCm38) missense probably benign 0.19
R0518:Trank1 UTSW 9 111,333,808 (GRCm38) missense probably damaging 1.00
R0560:Trank1 UTSW 9 111,391,086 (GRCm38) missense possibly damaging 0.88
R0637:Trank1 UTSW 9 111,390,441 (GRCm38) missense probably damaging 1.00
R0731:Trank1 UTSW 9 111,365,488 (GRCm38) missense probably damaging 1.00
R0761:Trank1 UTSW 9 111,366,613 (GRCm38) missense probably damaging 1.00
R0766:Trank1 UTSW 9 111,347,469 (GRCm38) missense probably benign 0.45
R0827:Trank1 UTSW 9 111,349,417 (GRCm38) unclassified probably benign
R1005:Trank1 UTSW 9 111,333,721 (GRCm38) missense probably benign 0.13
R1108:Trank1 UTSW 9 111,365,307 (GRCm38) missense probably benign 0.00
R1155:Trank1 UTSW 9 111,366,970 (GRCm38) missense possibly damaging 0.95
R1470:Trank1 UTSW 9 111,343,232 (GRCm38) missense possibly damaging 0.91
R1470:Trank1 UTSW 9 111,343,232 (GRCm38) missense possibly damaging 0.91
R1596:Trank1 UTSW 9 111,366,290 (GRCm38) missense possibly damaging 0.93
R1601:Trank1 UTSW 9 111,373,477 (GRCm38) missense probably damaging 1.00
R1751:Trank1 UTSW 9 111,391,479 (GRCm38) missense probably benign
R1754:Trank1 UTSW 9 111,392,871 (GRCm38) missense probably benign 0.00
R1767:Trank1 UTSW 9 111,391,479 (GRCm38) missense probably benign
R1768:Trank1 UTSW 9 111,392,927 (GRCm38) missense probably damaging 0.96
R1809:Trank1 UTSW 9 111,392,825 (GRCm38) missense probably benign 0.34
R1912:Trank1 UTSW 9 111,390,709 (GRCm38) missense probably benign 0.00
R1920:Trank1 UTSW 9 111,347,928 (GRCm38) critical splice donor site probably null
R1960:Trank1 UTSW 9 111,391,628 (GRCm38) missense probably damaging 1.00
R1993:Trank1 UTSW 9 111,378,832 (GRCm38) missense probably benign 0.20
R2012:Trank1 UTSW 9 111,365,028 (GRCm38) missense probably benign
R2025:Trank1 UTSW 9 111,392,039 (GRCm38) missense probably benign 0.01
R2050:Trank1 UTSW 9 111,364,788 (GRCm38) missense probably damaging 1.00
R2857:Trank1 UTSW 9 111,366,933 (GRCm38) missense probably benign 0.00
R2912:Trank1 UTSW 9 111,392,483 (GRCm38) missense probably damaging 0.98
R2962:Trank1 UTSW 9 111,352,080 (GRCm38) missense probably damaging 1.00
R3030:Trank1 UTSW 9 111,391,530 (GRCm38) missense possibly damaging 0.63
R3821:Trank1 UTSW 9 111,378,819 (GRCm38) missense probably damaging 1.00
R3822:Trank1 UTSW 9 111,378,819 (GRCm38) missense probably damaging 1.00
R3892:Trank1 UTSW 9 111,364,759 (GRCm38) missense probably benign 0.03
R4105:Trank1 UTSW 9 111,352,197 (GRCm38) missense probably damaging 1.00
R4166:Trank1 UTSW 9 111,373,524 (GRCm38) nonsense probably null
R4237:Trank1 UTSW 9 111,367,035 (GRCm38) missense probably benign 0.04
R4239:Trank1 UTSW 9 111,367,035 (GRCm38) missense probably benign 0.04
R4394:Trank1 UTSW 9 111,365,197 (GRCm38) missense possibly damaging 0.86
R4417:Trank1 UTSW 9 111,365,968 (GRCm38) missense probably benign 0.17
R4611:Trank1 UTSW 9 111,362,261 (GRCm38) missense probably damaging 1.00
R4694:Trank1 UTSW 9 111,392,061 (GRCm38) missense probably benign 0.40
R4731:Trank1 UTSW 9 111,390,410 (GRCm38) missense probably damaging 1.00
R4843:Trank1 UTSW 9 111,366,078 (GRCm38) missense probably benign 0.00
R4852:Trank1 UTSW 9 111,391,895 (GRCm38) missense possibly damaging 0.68
R4859:Trank1 UTSW 9 111,365,010 (GRCm38) missense probably benign 0.17
R4868:Trank1 UTSW 9 111,365,641 (GRCm38) missense probably damaging 1.00
R5080:Trank1 UTSW 9 111,389,221 (GRCm38) missense probably damaging 0.99
R5156:Trank1 UTSW 9 111,390,694 (GRCm38) missense probably damaging 1.00
R5174:Trank1 UTSW 9 111,365,559 (GRCm38) missense probably benign 0.00
R5234:Trank1 UTSW 9 111,386,467 (GRCm38) missense probably damaging 1.00
R5386:Trank1 UTSW 9 111,362,402 (GRCm38) missense probably benign 0.12
R5419:Trank1 UTSW 9 111,391,301 (GRCm38) missense probably damaging 1.00
R5435:Trank1 UTSW 9 111,391,890 (GRCm38) missense probably benign 0.00
R5444:Trank1 UTSW 9 111,392,958 (GRCm38) missense probably benign 0.04
R5543:Trank1 UTSW 9 111,366,112 (GRCm38) missense probably damaging 0.97
R5560:Trank1 UTSW 9 111,390,567 (GRCm38) missense probably damaging 1.00
R5772:Trank1 UTSW 9 111,366,676 (GRCm38) missense possibly damaging 0.86
R5774:Trank1 UTSW 9 111,391,226 (GRCm38) missense probably damaging 1.00
R5843:Trank1 UTSW 9 111,365,860 (GRCm38) missense possibly damaging 0.59
R5858:Trank1 UTSW 9 111,392,536 (GRCm38) missense probably benign
R5878:Trank1 UTSW 9 111,366,685 (GRCm38) missense possibly damaging 0.93
R5900:Trank1 UTSW 9 111,391,716 (GRCm38) missense probably damaging 1.00
R5917:Trank1 UTSW 9 111,362,417 (GRCm38) missense probably benign 0.38
R5954:Trank1 UTSW 9 111,365,133 (GRCm38) missense probably benign 0.13
R6041:Trank1 UTSW 9 111,377,796 (GRCm38) missense possibly damaging 0.94
R6112:Trank1 UTSW 9 111,391,737 (GRCm38) missense probably damaging 1.00
R6165:Trank1 UTSW 9 111,391,872 (GRCm38) missense probably benign 0.00
R6255:Trank1 UTSW 9 111,352,246 (GRCm38) critical splice donor site probably null
R6395:Trank1 UTSW 9 111,367,200 (GRCm38) missense probably damaging 1.00
R6567:Trank1 UTSW 9 111,347,521 (GRCm38) missense probably benign 0.02
R6644:Trank1 UTSW 9 111,364,834 (GRCm38) missense possibly damaging 0.85
R6724:Trank1 UTSW 9 111,365,916 (GRCm38) missense probably damaging 1.00
R6788:Trank1 UTSW 9 111,390,679 (GRCm38) missense probably damaging 1.00
R6831:Trank1 UTSW 9 111,377,899 (GRCm38) missense probably benign 0.00
R6934:Trank1 UTSW 9 111,373,090 (GRCm38) missense probably damaging 0.99
R7127:Trank1 UTSW 9 111,365,796 (GRCm38) missense possibly damaging 0.85
R7206:Trank1 UTSW 9 111,345,515 (GRCm38) critical splice donor site probably null
R7236:Trank1 UTSW 9 111,373,074 (GRCm38) missense possibly damaging 0.93
R7247:Trank1 UTSW 9 111,367,512 (GRCm38) missense probably damaging 1.00
R7292:Trank1 UTSW 9 111,377,870 (GRCm38) missense probably benign 0.02
R7310:Trank1 UTSW 9 111,367,126 (GRCm38) missense probably damaging 1.00
R7431:Trank1 UTSW 9 111,362,402 (GRCm38) missense probably benign 0.12
R7448:Trank1 UTSW 9 111,366,349 (GRCm38) missense probably benign 0.01
R7477:Trank1 UTSW 9 111,364,957 (GRCm38) missense probably benign 0.00
R7514:Trank1 UTSW 9 111,364,756 (GRCm38) missense probably damaging 1.00
R7595:Trank1 UTSW 9 111,365,991 (GRCm38) missense probably damaging 1.00
R7637:Trank1 UTSW 9 111,365,296 (GRCm38) missense possibly damaging 0.71
R7648:Trank1 UTSW 9 111,391,685 (GRCm38) missense probably benign
R7737:Trank1 UTSW 9 111,366,012 (GRCm38) nonsense probably null
R7784:Trank1 UTSW 9 111,364,103 (GRCm38) missense probably damaging 1.00
R7884:Trank1 UTSW 9 111,392,516 (GRCm38) missense probably benign
R7912:Trank1 UTSW 9 111,391,528 (GRCm38) missense probably benign 0.04
R7938:Trank1 UTSW 9 111,365,028 (GRCm38) missense probably benign
R7979:Trank1 UTSW 9 111,377,899 (GRCm38) missense probably benign 0.00
R8064:Trank1 UTSW 9 111,352,076 (GRCm38) nonsense probably null
R8100:Trank1 UTSW 9 111,392,793 (GRCm38) missense probably damaging 1.00
R8124:Trank1 UTSW 9 111,378,927 (GRCm38) missense probably benign 0.31
R8198:Trank1 UTSW 9 111,390,812 (GRCm38) missense probably benign 0.09
R8219:Trank1 UTSW 9 111,364,909 (GRCm38) missense probably damaging 1.00
R8223:Trank1 UTSW 9 111,365,889 (GRCm38) missense probably damaging 1.00
R8316:Trank1 UTSW 9 111,349,302 (GRCm38) missense probably benign 0.38
R8347:Trank1 UTSW 9 111,367,249 (GRCm38) missense probably damaging 1.00
R8436:Trank1 UTSW 9 111,391,382 (GRCm38) missense possibly damaging 0.86
R8489:Trank1 UTSW 9 111,390,275 (GRCm38) missense probably benign 0.01
R8682:Trank1 UTSW 9 111,365,344 (GRCm38) missense probably benign 0.01
R8768:Trank1 UTSW 9 111,389,276 (GRCm38) missense probably benign 0.00
R8770:Trank1 UTSW 9 111,390,824 (GRCm38) missense probably benign 0.00
R8829:Trank1 UTSW 9 111,347,523 (GRCm38) missense probably benign
R8838:Trank1 UTSW 9 111,364,905 (GRCm38) missense probably benign 0.03
R8855:Trank1 UTSW 9 111,312,221 (GRCm38) missense unknown
R8929:Trank1 UTSW 9 111,378,935 (GRCm38) missense possibly damaging 0.93
R9047:Trank1 UTSW 9 111,362,432 (GRCm38) missense probably damaging 0.99
R9090:Trank1 UTSW 9 111,345,479 (GRCm38) missense probably damaging 1.00
R9114:Trank1 UTSW 9 111,333,775 (GRCm38) missense probably damaging 1.00
R9133:Trank1 UTSW 9 111,391,702 (GRCm38) missense possibly damaging 0.93
R9177:Trank1 UTSW 9 111,392,511 (GRCm38) missense probably benign 0.00
R9178:Trank1 UTSW 9 111,367,200 (GRCm38) missense probably damaging 1.00
R9271:Trank1 UTSW 9 111,345,479 (GRCm38) missense probably damaging 1.00
R9314:Trank1 UTSW 9 111,365,981 (GRCm38) missense probably damaging 1.00
R9373:Trank1 UTSW 9 111,365,191 (GRCm38) missense probably benign 0.25
R9380:Trank1 UTSW 9 111,392,670 (GRCm38) missense probably benign 0.07
R9435:Trank1 UTSW 9 111,364,822 (GRCm38) missense probably benign 0.04
R9501:Trank1 UTSW 9 111,347,875 (GRCm38) missense probably benign 0.00
R9593:Trank1 UTSW 9 111,362,297 (GRCm38) missense probably benign 0.30
R9601:Trank1 UTSW 9 111,373,125 (GRCm38) missense probably benign 0.18
R9729:Trank1 UTSW 9 111,391,469 (GRCm38) missense probably damaging 1.00
X0064:Trank1 UTSW 9 111,343,236 (GRCm38) missense possibly damaging 0.57
Z1088:Trank1 UTSW 9 111,364,710 (GRCm38) missense probably damaging 0.99
Z1177:Trank1 UTSW 9 111,392,870 (GRCm38) missense possibly damaging 0.47
Z1177:Trank1 UTSW 9 111,367,377 (GRCm38) missense possibly damaging 0.83
Z1177:Trank1 UTSW 9 111,311,902 (GRCm38) missense unknown
Posted On 2016-08-02