Incidental Mutation 'IGL03148:Rars2'
ID |
410963 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Rars2
|
Ensembl Gene |
ENSMUSG00000028292 |
Gene Name |
arginyl-tRNA synthetase 2, mitochondrial |
Synonyms |
1500002I10Rik, PRO1992, Rarsl |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
IGL03148
|
Quality Score |
|
Status
|
|
Chromosome |
4 |
Chromosomal Location |
34614957-34660167 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 34650243 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 343
(I343F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000029968
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029968]
|
AlphaFold |
Q3U186 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000029968
AA Change: I343F
PolyPhen 2
Score 0.817 (Sensitivity: 0.84; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000029968 Gene: ENSMUSG00000028292 AA Change: I343F
Domain | Start | End | E-Value | Type |
Pfam:tRNA-synt_1d
|
110 |
449 |
1e-97 |
PFAM |
DALR_1
|
463 |
578 |
3.64e-31 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141519
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142045
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 31 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2300003K06Rik |
A |
G |
11: 99,728,079 (GRCm39) |
S255P |
unknown |
Het |
Adamtsl2 |
T |
A |
2: 26,974,071 (GRCm39) |
Y125N |
probably damaging |
Het |
Ankrd9 |
T |
C |
12: 110,943,293 (GRCm39) |
E214G |
probably benign |
Het |
Bhmt2 |
T |
A |
13: 93,803,161 (GRCm39) |
D124V |
possibly damaging |
Het |
Ccdc150 |
A |
G |
1: 54,317,874 (GRCm39) |
H271R |
possibly damaging |
Het |
Clcn1 |
T |
G |
6: 42,276,925 (GRCm39) |
|
probably null |
Het |
Col6a3 |
T |
A |
1: 90,755,588 (GRCm39) |
I234F |
probably benign |
Het |
Cpa5 |
T |
A |
6: 30,630,436 (GRCm39) |
M330K |
probably damaging |
Het |
Csmd2 |
G |
A |
4: 128,278,062 (GRCm39) |
C995Y |
probably damaging |
Het |
D630003M21Rik |
T |
C |
2: 158,059,144 (GRCm39) |
E252G |
probably damaging |
Het |
Dhrs1 |
A |
T |
14: 55,978,748 (GRCm39) |
Y133* |
probably null |
Het |
Dnaaf10 |
G |
A |
11: 17,179,845 (GRCm39) |
G282E |
probably damaging |
Het |
Dock10 |
T |
C |
1: 80,518,075 (GRCm39) |
I1300V |
probably benign |
Het |
Efcab12 |
T |
C |
6: 115,787,952 (GRCm39) |
Y670C |
probably damaging |
Het |
Frg1 |
T |
G |
8: 41,864,321 (GRCm39) |
K66N |
probably benign |
Het |
Gbp2b |
C |
A |
3: 142,312,642 (GRCm39) |
H342N |
probably benign |
Het |
Gria4 |
T |
A |
9: 4,464,295 (GRCm39) |
I556F |
possibly damaging |
Het |
Kcnh1 |
T |
G |
1: 191,959,307 (GRCm39) |
I287S |
probably damaging |
Het |
Map1b |
A |
G |
13: 99,578,203 (GRCm39) |
L150P |
probably damaging |
Het |
Map3k4 |
C |
T |
17: 12,457,045 (GRCm39) |
R1299Q |
probably benign |
Het |
Mapk10 |
T |
C |
5: 103,073,971 (GRCm39) |
N407D |
probably damaging |
Het |
Mcemp1 |
T |
A |
8: 3,717,390 (GRCm39) |
|
probably null |
Het |
Nav1 |
A |
C |
1: 135,397,762 (GRCm39) |
N802K |
possibly damaging |
Het |
Pcdhb2 |
T |
A |
18: 37,429,831 (GRCm39) |
N601K |
probably damaging |
Het |
Pi4ka |
T |
A |
16: 17,172,053 (GRCm39) |
H564L |
probably damaging |
Het |
Pnp |
T |
A |
14: 51,188,185 (GRCm39) |
|
probably benign |
Het |
Ppp2r2a |
G |
T |
14: 67,259,744 (GRCm39) |
N317K |
probably benign |
Het |
Pramel47 |
A |
G |
5: 95,489,177 (GRCm39) |
T207A |
possibly damaging |
Het |
Rnf213 |
T |
C |
11: 119,355,833 (GRCm39) |
F4092S |
probably damaging |
Het |
Tcp11 |
A |
G |
17: 28,289,444 (GRCm39) |
V209A |
possibly damaging |
Het |
Tet2 |
T |
C |
3: 133,187,124 (GRCm39) |
S1102G |
probably benign |
Het |
|
Other mutations in Rars2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02121:Rars2
|
APN |
4 |
34,657,219 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02143:Rars2
|
APN |
4 |
34,623,404 (GRCm39) |
splice site |
probably benign |
|
IGL02378:Rars2
|
APN |
4 |
34,656,199 (GRCm39) |
missense |
possibly damaging |
0.51 |
IGL03035:Rars2
|
APN |
4 |
34,656,865 (GRCm39) |
critical splice donor site |
probably null |
|
R0238:Rars2
|
UTSW |
4 |
34,656,030 (GRCm39) |
missense |
probably benign |
0.00 |
R0238:Rars2
|
UTSW |
4 |
34,656,030 (GRCm39) |
missense |
probably benign |
0.00 |
R0238:Rars2
|
UTSW |
4 |
34,645,838 (GRCm39) |
missense |
probably damaging |
1.00 |
R0238:Rars2
|
UTSW |
4 |
34,645,838 (GRCm39) |
missense |
probably damaging |
1.00 |
R0671:Rars2
|
UTSW |
4 |
34,630,505 (GRCm39) |
nonsense |
probably null |
|
R0967:Rars2
|
UTSW |
4 |
34,646,587 (GRCm39) |
missense |
probably benign |
0.01 |
R2276:Rars2
|
UTSW |
4 |
34,656,835 (GRCm39) |
missense |
probably damaging |
0.96 |
R3726:Rars2
|
UTSW |
4 |
34,645,787 (GRCm39) |
missense |
probably benign |
|
R4642:Rars2
|
UTSW |
4 |
34,656,229 (GRCm39) |
missense |
probably damaging |
1.00 |
R5144:Rars2
|
UTSW |
4 |
34,656,793 (GRCm39) |
missense |
probably benign |
0.00 |
R5714:Rars2
|
UTSW |
4 |
34,645,779 (GRCm39) |
missense |
probably benign |
0.00 |
R5919:Rars2
|
UTSW |
4 |
34,657,232 (GRCm39) |
missense |
probably damaging |
0.98 |
R5946:Rars2
|
UTSW |
4 |
34,656,855 (GRCm39) |
missense |
possibly damaging |
0.46 |
R7200:Rars2
|
UTSW |
4 |
34,645,747 (GRCm39) |
missense |
probably benign |
0.01 |
R8049:Rars2
|
UTSW |
4 |
34,650,217 (GRCm39) |
missense |
probably benign |
0.01 |
R8202:Rars2
|
UTSW |
4 |
34,656,180 (GRCm39) |
missense |
probably damaging |
1.00 |
R8558:Rars2
|
UTSW |
4 |
34,657,199 (GRCm39) |
missense |
probably damaging |
0.98 |
R8772:Rars2
|
UTSW |
4 |
34,623,488 (GRCm39) |
missense |
probably benign |
0.03 |
R9401:Rars2
|
UTSW |
4 |
34,654,819 (GRCm39) |
missense |
probably damaging |
1.00 |
R9553:Rars2
|
UTSW |
4 |
34,637,014 (GRCm39) |
missense |
probably damaging |
1.00 |
R9705:Rars2
|
UTSW |
4 |
34,646,561 (GRCm39) |
missense |
possibly damaging |
0.83 |
X0011:Rars2
|
UTSW |
4 |
34,652,176 (GRCm39) |
missense |
probably benign |
|
|
Posted On |
2016-08-02 |