Incidental Mutation 'IGL03149:Gm8237'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm8237
Ensembl Gene ENSMUSG00000090707
Gene Namepredicted gene 8237
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL03149
Quality Score
Chromosomal Location5857918-5880382 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 5864451 bp
Amino Acid Change Isoleucine to Threonine at position 37 (I37T)
Ref Sequence ENSEMBL: ENSMUSP00000127555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164484] [ENSMUST00000178594]
Predicted Effect probably benign
Transcript: ENSMUST00000164484
AA Change: I37T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000127555
Gene: ENSMUSG00000090707
AA Change: I37T

Pfam:Takusan 48 128 6.5e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178594
SMART Domains Protein: ENSMUSP00000136613
Gene: ENSMUSG00000090707

Pfam:Takusan 1 74 4.5e-27 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap10 A G 8: 77,409,538 probably benign Het
Arhgap42 A G 9: 9,008,084 I546T possibly damaging Het
Arsj A T 3: 126,439,404 probably benign Het
Ash2l A G 8: 25,818,622 V543A probably benign Het
B4galnt3 A G 6: 120,231,594 probably benign Het
Blvra T A 2: 127,082,951 V11E probably damaging Het
Calcb T C 7: 114,720,136 L51P probably damaging Het
Cd36 T A 5: 17,820,565 K52N probably benign Het
Cebpz T C 17: 78,922,553 N857S probably benign Het
Ces1b A G 8: 93,064,874 probably benign Het
Clspn T C 4: 126,576,502 probably benign Het
Cr2 A T 1: 195,166,366 L283H probably damaging Het
Ctc1 T C 11: 69,031,161 V811A possibly damaging Het
Ctsk T C 3: 95,501,419 S65P possibly damaging Het
Ddx51 A G 5: 110,653,734 N83D probably benign Het
Eci2 T C 13: 34,988,313 T146A probably benign Het
Erbin T C 13: 103,841,163 N629D possibly damaging Het
Etfbkmt A G 6: 149,144,283 E45G probably damaging Het
Fat4 A G 3: 38,991,685 N3951S probably damaging Het
Fktn T C 4: 53,744,653 V311A probably benign Het
Garem1 G T 18: 21,131,466 P534T probably damaging Het
Ikzf5 T C 7: 131,396,765 K13E probably damaging Het
Kl T A 5: 150,982,735 C523* probably null Het
Klhl7 G A 5: 24,159,689 V574I probably benign Het
Lyst T C 13: 13,681,444 V2450A probably benign Het
Map3k6 A T 4: 133,249,688 I819F probably damaging Het
Mphosph9 T C 5: 124,263,011 E891G probably damaging Het
Myo7b A G 18: 32,014,302 S63P probably damaging Het
Ndufaf7 C T 17: 78,945,010 R283C possibly damaging Het
Nepro G T 16: 44,727,099 A60S probably damaging Het
Nop56 T C 2: 130,277,525 S354P probably damaging Het
Nwd2 T A 5: 63,805,995 L974H probably damaging Het
Olfr1253 T C 2: 89,752,828 probably null Het
Olfr600 A T 7: 103,346,849 H26Q probably benign Het
Pacsin3 T A 2: 91,261,507 probably benign Het
Parp12 C T 6: 39,114,231 D142N probably benign Het
Pcdh15 G A 10: 74,630,695 D1449N probably damaging Het
Pcsk7 C T 9: 45,909,480 T70M probably benign Het
Pld4 T C 12: 112,766,829 F280L probably benign Het
Ppm1k C A 6: 57,524,774 A135S probably damaging Het
Prkcq A T 2: 11,232,545 Y45F probably benign Het
Prom1 T A 5: 44,029,734 I385F probably damaging Het
Prss12 A G 3: 123,505,387 N603D probably benign Het
Ptbp2 G T 3: 119,720,425 T501K possibly damaging Het
Ranbp17 C A 11: 33,243,183 R957L possibly damaging Het
Rasl10a T C 11: 5,058,429 Y42H possibly damaging Het
Serpina9 G A 12: 104,008,610 Q95* probably null Het
Serpinb1b C A 13: 33,085,292 Q3K possibly damaging Het
Sgo2b T A 8: 63,926,583 M1072L probably benign Het
Slc1a5 T C 7: 16,789,820 V250A probably damaging Het
Slc30a6 T C 17: 74,423,023 S303P probably damaging Het
Tbc1d2 A T 4: 46,637,619 I209N probably benign Het
Tmc4 T A 7: 3,667,178 I484L probably benign Het
Ttll5 G A 12: 85,918,984 E36K probably damaging Het
Unc93b1 A G 19: 3,944,041 M391V probably benign Het
Xpo5 T A 17: 46,215,814 probably null Het
Other mutations in Gm8237
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00264:Gm8237 APN 14 5864475 missense probably benign 0.01
IGL01380:Gm8237 APN 14 5863703 unclassified probably null
IGL02311:Gm8237 APN 14 5864425 splice site probably null
IGL02491:Gm8237 APN 14 5863577 nonsense probably null
R2520:Gm8237 UTSW 14 5863642 missense possibly damaging 0.52
Posted On2016-08-02