Incidental Mutation 'IGL03150:Trim25'
ID 411056
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim25
Ensembl Gene ENSMUSG00000000275
Gene Name tripartite motif-containing 25
Synonyms Zfp147, estrogen-responsive finger protein
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03150
Quality Score
Status
Chromosome 11
Chromosomal Location 88890202-88911119 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88890831 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 173 (C173R)
Ref Sequence ENSEMBL: ENSMUSP00000103528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000284] [ENSMUST00000100627] [ENSMUST00000107896]
AlphaFold Q61510
PDB Structure PRY-SPRY domain of Trim25 [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000000284
AA Change: C173R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000000284
Gene: ENSMUSG00000000275
AA Change: C173R

DomainStartEndE-ValueType
RING 13 53 8.04e-9 SMART
Blast:SPEC 189 288 5e-34 BLAST
PDB:4LTB|B 189 380 7e-69 PDB
PRY 453 505 3.44e-17 SMART
SPRY 506 626 9.62e-31 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000100627
AA Change: C173R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000098192
Gene: ENSMUSG00000000275
AA Change: C173R

DomainStartEndE-ValueType
RING 13 53 8.04e-9 SMART
Blast:BBOX 151 186 3e-8 BLAST
Blast:SPEC 189 288 2e-37 BLAST
PDB:4LTB|B 189 380 2e-71 PDB
Predicted Effect probably damaging
Transcript: ENSMUST00000107896
AA Change: C173R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103528
Gene: ENSMUSG00000000275
AA Change: C173R

DomainStartEndE-ValueType
RING 13 53 8.04e-9 SMART
Blast:SPEC 189 288 3e-34 BLAST
PDB:4LTB|B 189 380 8e-69 PDB
low complexity region 382 393 N/A INTRINSIC
PRY 461 513 3.44e-17 SMART
SPRY 514 634 9.62e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128078
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations result in a compromised response to estrogen resulting in functional but small uteri. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadat C T 8: 60,996,596 (GRCm39) S399L probably damaging Het
Bltp1 T C 3: 37,002,215 (GRCm39) S1387P probably damaging Het
Corin T C 5: 72,460,201 (GRCm39) D886G probably damaging Het
Cracd G A 5: 77,015,097 (GRCm39) E57K probably damaging Het
Eif2ak3 A T 6: 70,869,420 (GRCm39) K702N possibly damaging Het
Ercc6 G T 14: 32,280,531 (GRCm39) M709I probably damaging Het
Foxa1 T A 12: 57,589,082 (GRCm39) E379D probably benign Het
Fscb C T 12: 64,519,204 (GRCm39) G754D unknown Het
Gzmb C T 14: 56,497,839 (GRCm39) V134I probably benign Het
Iho1 G T 9: 108,282,155 (GRCm39) T511K probably damaging Het
Muc5b A G 7: 141,419,246 (GRCm39) T4010A possibly damaging Het
Necab3 A G 2: 154,396,662 (GRCm39) Y55H probably damaging Het
Nova1 T C 12: 46,747,455 (GRCm39) N274S possibly damaging Het
Nup54 C A 5: 92,576,023 (GRCm39) G156V probably damaging Het
Obscn A T 11: 58,942,549 (GRCm39) C4317S probably damaging Het
Papln T A 12: 83,829,758 (GRCm39) W960R probably damaging Het
Pax4 C A 6: 28,444,338 (GRCm39) G239W probably null Het
Pcdhb15 C A 18: 37,608,067 (GRCm39) T433N probably damaging Het
Ptprj A G 2: 90,290,955 (GRCm39) S502P probably damaging Het
Slit3 A G 11: 35,399,084 (GRCm39) R150G possibly damaging Het
Srgap2 A T 1: 131,238,338 (GRCm39) V658E probably damaging Het
Taar7e A T 10: 23,913,528 (GRCm39) D6V probably benign Het
Trmt1l T C 1: 151,329,643 (GRCm39) S529P probably benign Het
Ubn2 C T 6: 38,440,649 (GRCm39) P174S probably benign Het
Ubox5 A G 2: 130,442,060 (GRCm39) V209A probably benign Het
Vmn2r72 A G 7: 85,400,384 (GRCm39) F222L probably damaging Het
Xpot C T 10: 121,445,091 (GRCm39) A374T probably benign Het
Zfp451 A G 1: 33,816,535 (GRCm39) C472R probably damaging Het
Zfp777 A G 6: 48,021,059 (GRCm39) W232R probably damaging Het
Other mutations in Trim25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01707:Trim25 APN 11 88,890,517 (GRCm39) missense probably damaging 0.96
IGL02398:Trim25 APN 11 88,890,630 (GRCm39) missense probably damaging 1.00
R0003:Trim25 UTSW 11 88,906,598 (GRCm39) missense probably benign 0.01
R0184:Trim25 UTSW 11 88,890,466 (GRCm39) missense probably damaging 1.00
R0707:Trim25 UTSW 11 88,890,564 (GRCm39) missense probably benign 0.03
R1855:Trim25 UTSW 11 88,906,407 (GRCm39) missense probably benign 0.04
R1936:Trim25 UTSW 11 88,895,576 (GRCm39) missense probably benign 0.03
R2229:Trim25 UTSW 11 88,907,447 (GRCm39) missense probably damaging 0.97
R3401:Trim25 UTSW 11 88,901,707 (GRCm39) missense probably benign
R5159:Trim25 UTSW 11 88,890,358 (GRCm39) missense probably benign 0.20
R5378:Trim25 UTSW 11 88,900,093 (GRCm39) missense probably damaging 1.00
R6149:Trim25 UTSW 11 88,906,362 (GRCm39) missense probably benign 0.00
R6867:Trim25 UTSW 11 88,901,713 (GRCm39) missense probably benign 0.00
R6996:Trim25 UTSW 11 88,890,329 (GRCm39) missense probably benign 0.00
R7055:Trim25 UTSW 11 88,890,750 (GRCm39) missense probably benign
R7310:Trim25 UTSW 11 88,906,608 (GRCm39) missense probably benign 0.03
R7451:Trim25 UTSW 11 88,906,563 (GRCm39) missense possibly damaging 0.76
R7632:Trim25 UTSW 11 88,906,602 (GRCm39) missense probably null 0.91
R7767:Trim25 UTSW 11 88,899,943 (GRCm39) critical splice acceptor site probably null
R8132:Trim25 UTSW 11 88,907,432 (GRCm39) missense probably damaging 0.99
R8785:Trim25 UTSW 11 88,904,340 (GRCm39) missense probably benign 0.00
R8978:Trim25 UTSW 11 88,907,027 (GRCm39) missense probably benign 0.01
R9135:Trim25 UTSW 11 88,899,988 (GRCm39) missense probably benign
R9189:Trim25 UTSW 11 88,901,731 (GRCm39) missense probably benign 0.00
R9348:Trim25 UTSW 11 88,900,167 (GRCm39) nonsense probably null
R9667:Trim25 UTSW 11 88,907,188 (GRCm39) missense probably damaging 1.00
R9731:Trim25 UTSW 11 88,906,391 (GRCm39) missense probably benign 0.00
X0022:Trim25 UTSW 11 88,906,422 (GRCm39) missense probably benign 0.05
Posted On 2016-08-02