Incidental Mutation 'IGL03151:Zfp952'
ID411091
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp952
Ensembl Gene ENSMUSG00000053390
Gene Namezinc finger protein 952
SynonymsC920016K16Rik
Accession Numbers

Genbank: NM_001045559; MGI: 2441928

Is this an essential gene? Probably non essential (E-score: 0.108) question?
Stock #IGL03151
Quality Score
Status
Chromosome17
Chromosomal Location32993129-33005457 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 33003008 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 116 (S116P)
Ref Sequence ENSEMBL: ENSMUSP00000123066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087666] [ENSMUST00000157017]
Predicted Effect probably benign
Transcript: ENSMUST00000087666
AA Change: S154P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000084949
Gene: ENSMUSG00000053390
AA Change: S154P

DomainStartEndE-ValueType
KRAB 10 73 4.6e-14 SMART
ZnF_C2H2 251 273 3.44e-4 SMART
ZnF_C2H2 279 301 1.28e-3 SMART
ZnF_C2H2 307 329 1.36e-2 SMART
ZnF_C2H2 335 357 2.75e-3 SMART
ZnF_C2H2 363 385 9.44e-2 SMART
ZnF_C2H2 391 413 1.47e-3 SMART
ZnF_C2H2 419 441 2.91e-2 SMART
ZnF_C2H2 447 469 2.57e-3 SMART
ZnF_C2H2 475 497 1.43e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141815
Predicted Effect probably benign
Transcript: ENSMUST00000157017
AA Change: S116P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000123066
Gene: ENSMUSG00000053390
AA Change: S116P

DomainStartEndE-ValueType
Blast:KRAB 1 35 4e-17 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Gene trapped(2)

Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700074P13Rik A G 6: 40,926,012 F142S probably damaging Het
Acot1 G A 12: 84,014,552 A211T probably damaging Het
Ampd1 T C 3: 103,092,470 probably null Het
Armc3 T G 2: 19,238,698 L75R probably damaging Het
Atp9b T C 18: 80,776,850 D573G probably benign Het
Baz1a T A 12: 54,909,149 probably null Het
BC037034 A G 5: 138,262,672 L237S possibly damaging Het
C1ra A T 6: 124,519,771 I389F probably benign Het
Ccdc87 T A 19: 4,841,557 N692K probably benign Het
Ccr9 A G 9: 123,774,573 probably benign Het
Ces4a G T 8: 105,148,197 probably null Het
Dazap1 G A 10: 80,280,920 probably benign Het
Dock5 A G 14: 67,866,067 Y45H probably damaging Het
Eloa A T 4: 136,010,421 Y409* probably null Het
Fam170a A G 18: 50,281,641 E118G probably damaging Het
Fut2 C T 7: 45,650,769 G193E possibly damaging Het
Glra1 C T 11: 55,527,380 V180I probably damaging Het
Il17rb T C 14: 30,006,853 T28A probably benign Het
Ints9 T A 14: 65,032,340 V493E possibly damaging Het
Kcnq5 C T 1: 21,535,069 C204Y probably damaging Het
Npc1 A T 18: 12,219,275 N122K probably benign Het
Olfr124 G A 17: 37,805,268 G41D probably damaging Het
Podnl1 G A 8: 84,132,189 V548I probably benign Het
Prss21 A G 17: 23,869,402 T114A probably damaging Het
Rab10 G A 12: 3,249,812 T193M probably benign Het
Serpini1 T A 3: 75,613,296 S67T probably benign Het
Slc35b1 T C 11: 95,390,386 probably null Het
Sorbs2 A T 8: 45,799,713 H388L probably benign Het
Tfap2c T A 2: 172,557,190 C427* probably null Het
Ttn G T 2: 76,802,388 F14107L probably damaging Het
Upf1 G T 8: 70,335,387 T774K probably damaging Het
Vmn1r170 G A 7: 23,606,577 V135M probably benign Het
Vmn2r14 C T 5: 109,216,394 C552Y probably damaging Het
Zfp367 A G 13: 64,145,631 I147T probably damaging Het
Other mutations in Zfp952
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01865:Zfp952 APN 17 33002817 missense probably benign 0.00
IGL02560:Zfp952 APN 17 33002819 nonsense probably null
IGL03056:Zfp952 APN 17 33002766 missense probably damaging 0.98
0152:Zfp952 UTSW 17 33003221 splice site probably null
R0508:Zfp952 UTSW 17 33003005 missense possibly damaging 0.90
R1936:Zfp952 UTSW 17 33003669 missense possibly damaging 0.71
R3882:Zfp952 UTSW 17 33001975 nonsense probably null
R4560:Zfp952 UTSW 17 33003954 missense probably benign 0.33
R4649:Zfp952 UTSW 17 33002925 missense probably damaging 0.99
R7103:Zfp952 UTSW 17 33003632 missense possibly damaging 0.94
R7207:Zfp952 UTSW 17 33003515 missense possibly damaging 0.93
R7209:Zfp952 UTSW 17 33003470 missense possibly damaging 0.71
R7508:Zfp952 UTSW 17 33003782 missense probably benign 0.06
R7699:Zfp952 UTSW 17 33002009 missense possibly damaging 0.53
R8424:Zfp952 UTSW 17 33003217 missense probably benign 0.18
R8445:Zfp952 UTSW 17 33003578 missense possibly damaging 0.78
Z1177:Zfp952 UTSW 17 33003104 nonsense probably null
Posted On2016-08-02