Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03151:Zfp952'

411091

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp952

Ensembl Gene

ENSMUSG00000053390

Gene Name

zinc finger protein 952

Synonyms

C920016K16Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL03151

Quality Score

Status

Chromosome

Chromosomal Location

33212103-33224431 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 33221982 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 116 (S116P)

Ref Sequence

ENSEMBL: ENSMUSP00000123066 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087666] [ENSMUST00000157017]

AlphaFold

B0V2W4

Predicted Effect

probably benign
Transcript: ENSMUST00000087666
AA Change: S154P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000084949
Gene: ENSMUSG00000053390
AA Change: S154P

Domain	Start	End	E-Value	Type
KRAB	10	73	4.6e-14	SMART
ZnF_C2H2	251	273	3.44e-4	SMART
ZnF_C2H2	279	301	1.28e-3	SMART
ZnF_C2H2	307	329	1.36e-2	SMART
ZnF_C2H2	335	357	2.75e-3	SMART
ZnF_C2H2	363	385	9.44e-2	SMART
ZnF_C2H2	391	413	1.47e-3	SMART
ZnF_C2H2	419	441	2.91e-2	SMART
ZnF_C2H2	447	469	2.57e-3	SMART
ZnF_C2H2	475	497	1.43e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141815

Predicted Effect

probably benign
Transcript: ENSMUST00000157017
AA Change: S116P

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000123066
Gene: ENSMUSG00000053390
AA Change: S116P

Domain	Start	End	E-Value	Type
Blast:KRAB	1	35	4e-17	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(2) : Gene trapped(2)

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot1	G	A	12: 84,061,326 (GRCm39)	A211T	probably damaging	Het
Ampd1	T	C	3: 102,999,786 (GRCm39)		probably null	Het
Armc3	T	G	2: 19,243,509 (GRCm39)	L75R	probably damaging	Het
Atp9b	T	C	18: 80,820,065 (GRCm39)	D573G	probably benign	Het
Baz1a	T	A	12: 54,955,934 (GRCm39)		probably null	Het
C1ra	A	T	6: 124,496,730 (GRCm39)	I389F	probably benign	Het
Ccdc87	T	A	19: 4,891,585 (GRCm39)	N692K	probably benign	Het
Ccr9	A	G	9: 123,603,638 (GRCm39)		probably benign	Het
Ces4a	G	T	8: 105,874,829 (GRCm39)		probably null	Het
Dazap1	G	A	10: 80,116,754 (GRCm39)		probably benign	Het
Dock5	A	G	14: 68,103,516 (GRCm39)	Y45H	probably damaging	Het
Eloa	A	T	4: 135,737,732 (GRCm39)	Y409*	probably null	Het
Fam170a	A	G	18: 50,414,708 (GRCm39)	E118G	probably damaging	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
Glra1	C	T	11: 55,418,206 (GRCm39)	V180I	probably damaging	Het
Il17rb	T	C	14: 29,728,810 (GRCm39)	T28A	probably benign	Het
Ints9	T	A	14: 65,269,789 (GRCm39)	V493E	possibly damaging	Het
Kcnq5	C	T	1: 21,605,293 (GRCm39)	C204Y	probably damaging	Het
Npc1	A	T	18: 12,352,332 (GRCm39)	N122K	probably benign	Het
Or2b4	G	A	17: 38,116,159 (GRCm39)	G41D	probably damaging	Het
Podnl1	G	A	8: 84,858,818 (GRCm39)	V548I	probably benign	Het
Prss21	A	G	17: 24,088,376 (GRCm39)	T114A	probably damaging	Het
Prss59	A	G	6: 40,902,946 (GRCm39)	F142S	probably damaging	Het
Rab10	G	A	12: 3,299,812 (GRCm39)	T193M	probably benign	Het
Serpini1	T	A	3: 75,520,603 (GRCm39)	S67T	probably benign	Het
Slc35b1	T	C	11: 95,281,212 (GRCm39)		probably null	Het
Sorbs2	A	T	8: 46,252,750 (GRCm39)	H388L	probably benign	Het
Tfap2c	T	A	2: 172,399,110 (GRCm39)	C427*	probably null	Het
Trappc14	A	G	5: 138,260,934 (GRCm39)	L237S	possibly damaging	Het
Ttn	G	T	2: 76,632,732 (GRCm39)	F14107L	probably damaging	Het
Upf1	G	T	8: 70,788,037 (GRCm39)	T774K	probably damaging	Het
Vmn1r170	G	A	7: 23,306,002 (GRCm39)	V135M	probably benign	Het
Vmn2r14	C	T	5: 109,364,260 (GRCm39)	C552Y	probably damaging	Het
Zfp367	A	G	13: 64,293,445 (GRCm39)	I147T	probably damaging	Het

Other mutations in Zfp952

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01865:Zfp952	APN	17	33,221,791 (GRCm39)	missense	probably benign	0.00
IGL02560:Zfp952	APN	17	33,221,793 (GRCm39)	nonsense	probably null
IGL03056:Zfp952	APN	17	33,221,740 (GRCm39)	missense	probably damaging	0.98
0152:Zfp952	UTSW	17	33,222,195 (GRCm39)	splice site	probably null
R0508:Zfp952	UTSW	17	33,221,979 (GRCm39)	missense	possibly damaging	0.90
R1936:Zfp952	UTSW	17	33,222,643 (GRCm39)	missense	possibly damaging	0.71
R3882:Zfp952	UTSW	17	33,220,949 (GRCm39)	nonsense	probably null
R4560:Zfp952	UTSW	17	33,222,928 (GRCm39)	missense	probably benign	0.33
R4649:Zfp952	UTSW	17	33,221,899 (GRCm39)	missense	probably damaging	0.99
R7103:Zfp952	UTSW	17	33,222,606 (GRCm39)	missense	possibly damaging	0.94
R7207:Zfp952	UTSW	17	33,222,489 (GRCm39)	missense	possibly damaging	0.93
R7209:Zfp952	UTSW	17	33,222,444 (GRCm39)	missense	possibly damaging	0.71
R7508:Zfp952	UTSW	17	33,222,756 (GRCm39)	missense	probably benign	0.06
R7699:Zfp952	UTSW	17	33,220,983 (GRCm39)	missense	possibly damaging	0.53
R8424:Zfp952	UTSW	17	33,222,191 (GRCm39)	missense	probably benign	0.18
R8445:Zfp952	UTSW	17	33,222,552 (GRCm39)	missense	possibly damaging	0.78
R8711:Zfp952	UTSW	17	33,222,004 (GRCm39)	missense	possibly damaging	0.93
R8919:Zfp952	UTSW	17	33,220,628 (GRCm39)	missense	possibly damaging	0.71
R8970:Zfp952	UTSW	17	33,221,810 (GRCm39)	missense	probably benign
Z1177:Zfp952	UTSW	17	33,222,078 (GRCm39)	nonsense	probably null

Posted On

2016-08-02