Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03151:Ccr9'

411110

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccr9

Ensembl Gene

ENSMUSG00000029530

Gene Name

chemokine (C-C motif) receptor 9

Synonyms

Cmkbr10, GPR-9-6

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

IGL03151

Quality Score

Status

Chromosome

Chromosomal Location

123678439-123784330 bp(+) (GRCm38)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

A to G at 123774573 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000137144 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000111454] [ENSMUST00000163559] [ENSMUST00000166236] [ENSMUST00000168910] [ENSMUST00000180093]

Predicted Effect

probably benign
Transcript: ENSMUST00000111454

SMART Domains

Protein: ENSMUSP00000107081
Gene: ENSMUSG00000029530

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	47	320	1.2e-5	PFAM
Pfam:7tm_1	53	305	1.1e-51	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000163559

SMART Domains

Protein: ENSMUSP00000131782
Gene: ENSMUSG00000029530

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	59	332	5.9e-6	PFAM
Pfam:7tm_1	65	317	3.4e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000166236

SMART Domains

Protein: ENSMUSP00000127024
Gene: ENSMUSG00000029530

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	59	332	5.9e-6	PFAM
Pfam:7tm_1	65	317	4.6e-47	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000168910

SMART Domains

Protein: ENSMUSP00000126758
Gene: ENSMUSG00000029530

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	59	332	5.9e-6	PFAM
Pfam:7tm_1	65	317	3.4e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000172093

Predicted Effect

probably benign
Transcript: ENSMUST00000180093

SMART Domains

Protein: ENSMUSP00000137144
Gene: ENSMUSG00000029530

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	59	332	5.9e-6	PFAM
Pfam:7tm_1	65	317	3.4e-52	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214413

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215921

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous null mice have altered trafficing of lymphocytes to the intestine. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700074P13Rik	A	G	6: 40,926,012	F142S	probably damaging	Het
Acot1	G	A	12: 84,014,552	A211T	probably damaging	Het
Ampd1	T	C	3: 103,092,470		probably null	Het
Armc3	T	G	2: 19,238,698	L75R	probably damaging	Het
Atp9b	T	C	18: 80,776,850	D573G	probably benign	Het
Baz1a	T	A	12: 54,909,149		probably null	Het
BC037034	A	G	5: 138,262,672	L237S	possibly damaging	Het
C1ra	A	T	6: 124,519,771	I389F	probably benign	Het
Ccdc87	T	A	19: 4,841,557	N692K	probably benign	Het
Ces4a	G	T	8: 105,148,197		probably null	Het
Dazap1	G	A	10: 80,280,920		probably benign	Het
Dock5	A	G	14: 67,866,067	Y45H	probably damaging	Het
Eloa	A	T	4: 136,010,421	Y409*	probably null	Het
Fam170a	A	G	18: 50,281,641	E118G	probably damaging	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Glra1	C	T	11: 55,527,380	V180I	probably damaging	Het
Il17rb	T	C	14: 30,006,853	T28A	probably benign	Het
Ints9	T	A	14: 65,032,340	V493E	possibly damaging	Het
Kcnq5	C	T	1: 21,535,069	C204Y	probably damaging	Het
Npc1	A	T	18: 12,219,275	N122K	probably benign	Het
Olfr124	G	A	17: 37,805,268	G41D	probably damaging	Het
Podnl1	G	A	8: 84,132,189	V548I	probably benign	Het
Prss21	A	G	17: 23,869,402	T114A	probably damaging	Het
Rab10	G	A	12: 3,249,812	T193M	probably benign	Het
Serpini1	T	A	3: 75,613,296	S67T	probably benign	Het
Slc35b1	T	C	11: 95,390,386		probably null	Het
Sorbs2	A	T	8: 45,799,713	H388L	probably benign	Het
Tfap2c	T	A	2: 172,557,190	C427*	probably null	Het
Ttn	G	T	2: 76,802,388	F14107L	probably damaging	Het
Upf1	G	T	8: 70,335,387	T774K	probably damaging	Het
Vmn1r170	G	A	7: 23,606,577	V135M	probably benign	Het
Vmn2r14	C	T	5: 109,216,394	C552Y	probably damaging	Het
Zfp367	A	G	13: 64,145,631	I147T	probably damaging	Het
Zfp952	T	C	17: 33,003,008	S116P	probably benign	Het

Other mutations in Ccr9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Ccr9	APN	9	123780044	missense	probably benign	0.00
IGL00983:Ccr9	APN	9	123779286	missense	probably benign
IGL02466:Ccr9	APN	9	123779846	missense	probably damaging	1.00
IGL03302:Ccr9	APN	9	123779536	missense	probably damaging	1.00
hamlet	UTSW	9	123779439	missense	probably damaging	1.00
Laertes	UTSW	9	123779846	missense	probably damaging	1.00
Ophelia	UTSW	9	123779469	missense	probably damaging	1.00
R0310:Ccr9	UTSW	9	123774552	utr 5 prime	probably benign
R0393:Ccr9	UTSW	9	123779970	missense	probably benign	0.18
R0421:Ccr9	UTSW	9	123779606	missense	probably benign
R2069:Ccr9	UTSW	9	123779364	missense	probably benign	0.05
R3980:Ccr9	UTSW	9	123779376	missense	probably benign	0.14
R4645:Ccr9	UTSW	9	123779593	missense	probably benign	0.00
R4672:Ccr9	UTSW	9	123779687	missense	probably damaging	0.96
R4920:Ccr9	UTSW	9	123779439	missense	probably damaging	1.00
R5661:Ccr9	UTSW	9	123780099	missense	probably benign	0.04
R5964:Ccr9	UTSW	9	123779434	missense	probably benign	0.12
R7037:Ccr9	UTSW	9	123779971	missense	possibly damaging	0.52
R7500:Ccr9	UTSW	9	123779469	missense	probably damaging	1.00
R7620:Ccr9	UTSW	9	123779846	missense	probably damaging	1.00
R7670:Ccr9	UTSW	9	123779306	missense	probably damaging	0.98
R7762:Ccr9	UTSW	9	123779957	missense	probably benign	0.08
R8154:Ccr9	UTSW	9	123779831	missense	probably benign	0.00
R8283:Ccr9	UTSW	9	123779631	missense	probably damaging	1.00
R8525:Ccr9	UTSW	9	123779667	missense	probably benign	0.31
X0026:Ccr9	UTSW	9	123779501	missense	probably damaging	1.00

Posted On

2016-08-02