Incidental Mutation 'IGL03153:Lcor'
ID 411157
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lcor
Ensembl Gene ENSMUSG00000025019
Gene Name ligand dependent nuclear receptor corepressor
Synonyms LOC381224, A630025C20Rik, Gm340, 3110023F06Rik, Mlr2
Accession Numbers
Essential gene? Possibly essential (E-score: 0.560) question?
Stock # IGL03153
Quality Score
Status
Chromosome 19
Chromosomal Location 41471076-41574975 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 41546795 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 126 (S126R)
Ref Sequence ENSEMBL: ENSMUSP00000126441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067795] [ENSMUST00000163929]
AlphaFold Q6ZPI3
Predicted Effect probably damaging
Transcript: ENSMUST00000067795
AA Change: S126R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000067603
Gene: ENSMUSG00000025019
AA Change: S126R

DomainStartEndE-ValueType
low complexity region 36 48 N/A INTRINSIC
Pfam:HTH_psq 350 395 1.2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000163929
AA Change: S126R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000126441
Gene: ENSMUSG00000025019
AA Change: S126R

DomainStartEndE-ValueType
low complexity region 36 48 N/A INTRINSIC
Pfam:HTH_psq 350 395 5.1e-18 PFAM
Meta Mutation Damage Score 0.0834 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik A G 4: 62,465,563 (GRCm39) E419G possibly damaging Het
Abcg3 A G 5: 105,122,631 (GRCm39) probably benign Het
Adam17 T C 12: 21,395,698 (GRCm39) D256G probably damaging Het
Adgrb3 G A 1: 25,570,978 (GRCm39) R500* probably null Het
Aldh3a2 A G 11: 61,149,665 (GRCm39) Y234H probably damaging Het
Alpk3 A G 7: 80,743,143 (GRCm39) T987A probably benign Het
Amtn A G 5: 88,532,828 (GRCm39) K148E possibly damaging Het
Asap1 G A 15: 64,032,123 (GRCm39) T237M probably damaging Het
Ccdc124 A T 8: 71,321,573 (GRCm39) probably null Het
Cdon T C 9: 35,389,255 (GRCm39) Y787H probably damaging Het
Cimip4 T C 15: 78,269,516 (GRCm39) D188G probably damaging Het
Coro7 A G 16: 4,453,246 (GRCm39) probably null Het
Dram2 T A 3: 106,462,490 (GRCm39) probably benign Het
Drd5 T C 5: 38,477,124 (GRCm39) V39A probably benign Het
Ern1 A G 11: 106,300,924 (GRCm39) L490P possibly damaging Het
Fat1 A G 8: 45,483,160 (GRCm39) T3083A possibly damaging Het
Irgm1 A G 11: 48,757,094 (GRCm39) I239T probably damaging Het
Klhl10 A T 11: 100,347,758 (GRCm39) T605S probably benign Het
Lgi4 G T 7: 30,759,983 (GRCm39) V60F probably damaging Het
Lin37 G A 7: 30,256,585 (GRCm39) R84W probably damaging Het
Lmf1 A G 17: 25,804,624 (GRCm39) S97G possibly damaging Het
Oasl2 A G 5: 115,039,393 (GRCm39) T194A probably benign Het
Or5ac17 A G 16: 59,036,566 (GRCm39) S137P probably benign Het
Pnpo A T 11: 96,834,661 (GRCm39) F12I probably damaging Het
Prdm4 T C 10: 85,743,860 (GRCm39) T132A probably benign Het
Ptbp2 T C 3: 119,545,593 (GRCm39) T118A probably benign Het
Ptf1a T A 2: 19,451,456 (GRCm39) probably benign Het
Rev3l T A 10: 39,682,874 (GRCm39) F331I probably damaging Het
Rfx6 C A 10: 51,599,217 (GRCm39) S524* probably null Het
Scube3 A G 17: 28,386,032 (GRCm39) S758G possibly damaging Het
Slc44a2 T C 9: 21,254,496 (GRCm39) I257T probably benign Het
Spon1 A T 7: 113,629,579 (GRCm39) I408F probably damaging Het
Srpk1 C A 17: 28,811,240 (GRCm39) D541Y possibly damaging Het
Tenm4 A T 7: 96,522,969 (GRCm39) I1467F probably damaging Het
Uggt1 A C 1: 36,241,899 (GRCm39) V345G possibly damaging Het
Vmn1r23 A T 6: 57,902,917 (GRCm39) I287K probably damaging Het
Whamm A G 7: 81,239,280 (GRCm39) probably benign Het
Zeb1 A G 18: 5,770,511 (GRCm39) D888G probably damaging Het
Zfp263 A G 16: 3,564,744 (GRCm39) N253S possibly damaging Het
Zfp446 C A 7: 12,711,834 (GRCm39) A19E probably benign Het
Other mutations in Lcor
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00737:Lcor APN 19 41,541,139 (GRCm39) missense probably damaging 0.97
IGL02079:Lcor APN 19 41,544,126 (GRCm39) missense probably benign 0.40
IGL02100:Lcor APN 19 41,547,193 (GRCm39) missense possibly damaging 0.93
IGL02444:Lcor APN 19 41,547,450 (GRCm39) missense probably damaging 0.99
IGL02578:Lcor APN 19 41,547,589 (GRCm39) missense probably damaging 1.00
IGL03072:Lcor APN 19 41,547,253 (GRCm39) missense possibly damaging 0.85
IGL03118:Lcor APN 19 41,546,808 (GRCm39) missense probably damaging 0.99
BB003:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
BB013:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
R0006:Lcor UTSW 19 41,573,338 (GRCm39) missense probably benign 0.00
R0686:Lcor UTSW 19 41,570,811 (GRCm39) missense possibly damaging 0.73
R1104:Lcor UTSW 19 41,574,502 (GRCm39) missense probably damaging 0.99
R1278:Lcor UTSW 19 41,573,122 (GRCm39) missense probably benign 0.07
R1606:Lcor UTSW 19 41,573,513 (GRCm39) missense probably benign 0.35
R1756:Lcor UTSW 19 41,547,705 (GRCm39) missense probably benign
R1833:Lcor UTSW 19 41,573,387 (GRCm39) missense probably benign 0.00
R1889:Lcor UTSW 19 41,547,567 (GRCm39) missense probably damaging 0.99
R1905:Lcor UTSW 19 41,572,013 (GRCm39) missense possibly damaging 0.73
R1913:Lcor UTSW 19 41,546,913 (GRCm39) missense probably benign 0.40
R1983:Lcor UTSW 19 41,546,806 (GRCm39) missense probably damaging 0.98
R2697:Lcor UTSW 19 41,572,466 (GRCm39) missense probably benign 0.43
R2881:Lcor UTSW 19 41,571,488 (GRCm39) missense probably damaging 1.00
R3885:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3886:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3888:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R3889:Lcor UTSW 19 41,546,795 (GRCm39) missense probably damaging 0.98
R4720:Lcor UTSW 19 41,574,334 (GRCm39) missense probably benign 0.04
R4864:Lcor UTSW 19 41,573,803 (GRCm39) missense probably benign
R4908:Lcor UTSW 19 41,572,601 (GRCm39) missense probably benign 0.00
R5160:Lcor UTSW 19 41,544,053 (GRCm39) missense probably damaging 0.99
R5193:Lcor UTSW 19 41,570,969 (GRCm39) missense probably damaging 1.00
R5215:Lcor UTSW 19 41,574,371 (GRCm39) missense probably damaging 1.00
R5276:Lcor UTSW 19 41,573,478 (GRCm39) missense probably damaging 0.98
R5319:Lcor UTSW 19 41,574,791 (GRCm39) missense probably damaging 0.99
R5321:Lcor UTSW 19 41,573,643 (GRCm39) missense probably damaging 1.00
R5432:Lcor UTSW 19 41,573,042 (GRCm39) missense probably damaging 1.00
R5605:Lcor UTSW 19 41,571,302 (GRCm39) missense probably damaging 1.00
R5941:Lcor UTSW 19 41,574,839 (GRCm39) missense probably damaging 1.00
R6020:Lcor UTSW 19 41,571,986 (GRCm39) missense possibly damaging 0.88
R6024:Lcor UTSW 19 41,572,396 (GRCm39) missense possibly damaging 0.84
R6112:Lcor UTSW 19 41,547,520 (GRCm39) missense possibly damaging 0.92
R6149:Lcor UTSW 19 41,573,641 (GRCm39) missense probably damaging 1.00
R6260:Lcor UTSW 19 41,570,810 (GRCm39) missense possibly damaging 0.73
R6260:Lcor UTSW 19 41,570,809 (GRCm39) missense probably null 0.91
R6476:Lcor UTSW 19 41,571,518 (GRCm39) missense probably benign 0.04
R7051:Lcor UTSW 19 41,574,191 (GRCm39) missense probably benign 0.05
R7285:Lcor UTSW 19 41,572,754 (GRCm39) missense possibly damaging 0.91
R7372:Lcor UTSW 19 41,573,945 (GRCm39) missense probably damaging 1.00
R7762:Lcor UTSW 19 41,572,106 (GRCm39) missense probably benign 0.02
R7777:Lcor UTSW 19 41,547,234 (GRCm39) missense probably benign 0.33
R7833:Lcor UTSW 19 41,573,024 (GRCm39) missense probably benign 0.02
R7926:Lcor UTSW 19 41,571,008 (GRCm39) missense probably benign
R8164:Lcor UTSW 19 41,573,849 (GRCm39) missense probably damaging 1.00
R8319:Lcor UTSW 19 41,571,343 (GRCm39) missense probably damaging 1.00
R8323:Lcor UTSW 19 41,572,036 (GRCm39) missense probably benign 0.01
R8327:Lcor UTSW 19 41,570,996 (GRCm39) missense probably damaging 1.00
R8423:Lcor UTSW 19 41,573,888 (GRCm39) missense possibly damaging 0.95
R8556:Lcor UTSW 19 41,546,863 (GRCm39) frame shift probably null
R8780:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8781:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8788:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R8798:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9013:Lcor UTSW 19 41,573,189 (GRCm39) missense probably damaging 1.00
R9035:Lcor UTSW 19 41,573,399 (GRCm39) missense probably benign 0.00
R9065:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9067:Lcor UTSW 19 41,573,698 (GRCm39) missense probably damaging 1.00
R9083:Lcor UTSW 19 41,574,839 (GRCm39) missense probably damaging 0.99
R9105:Lcor UTSW 19 41,573,311 (GRCm39) missense possibly damaging 0.88
R9487:Lcor UTSW 19 41,573,685 (GRCm39) missense probably damaging 1.00
R9573:Lcor UTSW 19 41,573,471 (GRCm39) missense probably damaging 1.00
R9704:Lcor UTSW 19 41,572,498 (GRCm39) missense possibly damaging 0.61
X0013:Lcor UTSW 19 41,572,971 (GRCm39) missense probably damaging 0.99
Posted On 2016-08-02