Incidental Mutation 'IGL03153:Oasl2'
ID 411158
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oasl2
Ensembl Gene ENSMUSG00000029561
Gene Name 2'-5' oligoadenylate synthetase-like 2
Synonyms M1204, Mmu-OASL
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03153
Quality Score
Status
Chromosome 5
Chromosomal Location 115034997-115050295 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 115039393 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 194 (T194A)
Ref Sequence ENSEMBL: ENSMUSP00000031542 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031542] [ENSMUST00000124716] [ENSMUST00000146072] [ENSMUST00000150361]
AlphaFold Q9Z2F2
Predicted Effect probably benign
Transcript: ENSMUST00000031542
AA Change: T194A

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000031542
Gene: ENSMUSG00000029561
AA Change: T194A

DomainStartEndE-ValueType
low complexity region 63 73 N/A INTRINSIC
Pfam:OAS1_C 169 351 8.4e-77 PFAM
SCOP:d1euvb_ 355 427 4e-4 SMART
Blast:UBQ 355 430 9e-30 BLAST
UBQ 435 506 8.88e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000124716
SMART Domains Protein: ENSMUSP00000115070
Gene: ENSMUSG00000029561

DomainStartEndE-ValueType
Pfam:OAS1_C 1 131 1.2e-48 PFAM
SCOP:d1euvb_ 135 207 6e-5 SMART
Blast:UBQ 135 210 9e-32 BLAST
Blast:UBQ 215 240 5e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129707
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137828
Predicted Effect probably benign
Transcript: ENSMUST00000144064
Predicted Effect probably benign
Transcript: ENSMUST00000146072
SMART Domains Protein: ENSMUSP00000117795
Gene: ENSMUSG00000029561

DomainStartEndE-ValueType
PDB:1PX5|B 6 101 4e-10 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201445
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201919
Predicted Effect probably benign
Transcript: ENSMUST00000150361
SMART Domains Protein: ENSMUSP00000119042
Gene: ENSMUSG00000029561

DomainStartEndE-ValueType
PDB:1PX5|B 6 140 3e-13 PDB
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933430I17Rik A G 4: 62,465,563 (GRCm39) E419G possibly damaging Het
Abcg3 A G 5: 105,122,631 (GRCm39) probably benign Het
Adam17 T C 12: 21,395,698 (GRCm39) D256G probably damaging Het
Adgrb3 G A 1: 25,570,978 (GRCm39) R500* probably null Het
Aldh3a2 A G 11: 61,149,665 (GRCm39) Y234H probably damaging Het
Alpk3 A G 7: 80,743,143 (GRCm39) T987A probably benign Het
Amtn A G 5: 88,532,828 (GRCm39) K148E possibly damaging Het
Asap1 G A 15: 64,032,123 (GRCm39) T237M probably damaging Het
Ccdc124 A T 8: 71,321,573 (GRCm39) probably null Het
Cdon T C 9: 35,389,255 (GRCm39) Y787H probably damaging Het
Cimip4 T C 15: 78,269,516 (GRCm39) D188G probably damaging Het
Coro7 A G 16: 4,453,246 (GRCm39) probably null Het
Dram2 T A 3: 106,462,490 (GRCm39) probably benign Het
Drd5 T C 5: 38,477,124 (GRCm39) V39A probably benign Het
Ern1 A G 11: 106,300,924 (GRCm39) L490P possibly damaging Het
Fat1 A G 8: 45,483,160 (GRCm39) T3083A possibly damaging Het
Irgm1 A G 11: 48,757,094 (GRCm39) I239T probably damaging Het
Klhl10 A T 11: 100,347,758 (GRCm39) T605S probably benign Het
Lcor T A 19: 41,546,795 (GRCm39) S126R probably damaging Het
Lgi4 G T 7: 30,759,983 (GRCm39) V60F probably damaging Het
Lin37 G A 7: 30,256,585 (GRCm39) R84W probably damaging Het
Lmf1 A G 17: 25,804,624 (GRCm39) S97G possibly damaging Het
Or5ac17 A G 16: 59,036,566 (GRCm39) S137P probably benign Het
Pnpo A T 11: 96,834,661 (GRCm39) F12I probably damaging Het
Prdm4 T C 10: 85,743,860 (GRCm39) T132A probably benign Het
Ptbp2 T C 3: 119,545,593 (GRCm39) T118A probably benign Het
Ptf1a T A 2: 19,451,456 (GRCm39) probably benign Het
Rev3l T A 10: 39,682,874 (GRCm39) F331I probably damaging Het
Rfx6 C A 10: 51,599,217 (GRCm39) S524* probably null Het
Scube3 A G 17: 28,386,032 (GRCm39) S758G possibly damaging Het
Slc44a2 T C 9: 21,254,496 (GRCm39) I257T probably benign Het
Spon1 A T 7: 113,629,579 (GRCm39) I408F probably damaging Het
Srpk1 C A 17: 28,811,240 (GRCm39) D541Y possibly damaging Het
Tenm4 A T 7: 96,522,969 (GRCm39) I1467F probably damaging Het
Uggt1 A C 1: 36,241,899 (GRCm39) V345G possibly damaging Het
Vmn1r23 A T 6: 57,902,917 (GRCm39) I287K probably damaging Het
Whamm A G 7: 81,239,280 (GRCm39) probably benign Het
Zeb1 A G 18: 5,770,511 (GRCm39) D888G probably damaging Het
Zfp263 A G 16: 3,564,744 (GRCm39) N253S possibly damaging Het
Zfp446 C A 7: 12,711,834 (GRCm39) A19E probably benign Het
Other mutations in Oasl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02054:Oasl2 APN 5 115,035,867 (GRCm39) missense probably damaging 1.00
IGL02649:Oasl2 APN 5 115,035,753 (GRCm39) missense probably damaging 1.00
IGL02810:Oasl2 APN 5 115,035,852 (GRCm39) missense probably damaging 1.00
R0179:Oasl2 UTSW 5 115,048,973 (GRCm39) missense probably benign
R1318:Oasl2 UTSW 5 115,039,442 (GRCm39) missense probably benign 0.01
R1831:Oasl2 UTSW 5 115,039,367 (GRCm39) missense probably benign 0.00
R1941:Oasl2 UTSW 5 115,049,423 (GRCm39) utr 3 prime probably benign
R2068:Oasl2 UTSW 5 115,049,298 (GRCm39) missense probably benign 0.01
R2104:Oasl2 UTSW 5 115,049,063 (GRCm39) nonsense probably null
R2170:Oasl2 UTSW 5 115,044,861 (GRCm39) missense probably damaging 0.99
R2437:Oasl2 UTSW 5 115,049,357 (GRCm39) missense probably benign
R2882:Oasl2 UTSW 5 115,049,084 (GRCm39) missense probably damaging 1.00
R3960:Oasl2 UTSW 5 115,043,098 (GRCm39) missense probably benign 0.03
R3962:Oasl2 UTSW 5 115,035,808 (GRCm39) missense probably benign 0.01
R4609:Oasl2 UTSW 5 115,037,857 (GRCm39) missense possibly damaging 0.47
R4761:Oasl2 UTSW 5 115,037,836 (GRCm39) missense probably benign 0.00
R5242:Oasl2 UTSW 5 115,043,122 (GRCm39) missense possibly damaging 0.92
R5691:Oasl2 UTSW 5 115,037,828 (GRCm39) missense possibly damaging 0.93
R6594:Oasl2 UTSW 5 115,044,836 (GRCm39) missense probably benign 0.30
R7053:Oasl2 UTSW 5 115,049,291 (GRCm39) missense possibly damaging 0.82
R7062:Oasl2 UTSW 5 115,049,152 (GRCm39) nonsense probably null
R7688:Oasl2 UTSW 5 115,035,909 (GRCm39) missense probably benign 0.01
R7753:Oasl2 UTSW 5 115,043,118 (GRCm39) missense probably benign
R8026:Oasl2 UTSW 5 115,040,329 (GRCm39) unclassified probably benign
R8160:Oasl2 UTSW 5 115,039,347 (GRCm39) unclassified probably benign
R8479:Oasl2 UTSW 5 115,035,852 (GRCm39) missense probably damaging 1.00
R9429:Oasl2 UTSW 5 115,043,040 (GRCm39) missense probably benign
R9585:Oasl2 UTSW 5 115,035,901 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02