Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03155:Vmn1r222'

411208

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r222

Ensembl Gene

ENSMUSG00000061022

Gene Name

vomeronasal 1 receptor 222

Synonyms

V1rh16

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL03155

Quality Score

Status

Chromosome

Chromosomal Location

23232066-23233119 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23232693 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Tryptophan at position 117 (R117W)

Ref Sequence

ENSEMBL: ENSMUSP00000076365 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077116]

Predicted Effect

probably damaging
Transcript: ENSMUST00000077116
AA Change: R117W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000076365
Gene: ENSMUSG00000061022
AA Change: R117W

Domain	Start	End	E-Value	Type
Pfam:V1R	32	297	3.6e-39	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225143

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adra1d	C	T	2: 131,546,081	R518H	probably benign	Het
Akr7a5	T	A	4: 139,314,526	C190*	probably null	Het
Cct2	A	T	10: 117,060,671	L209Q	probably damaging	Het
Chordc1	T	A	9: 18,304,320	S123T	possibly damaging	Het
Crtap	T	C	9: 114,380,049	D309G	possibly damaging	Het
Csf2	T	C	11: 54,247,671	T115A	possibly damaging	Het
Dgkb	T	A	12: 38,139,459	I287N	probably damaging	Het
Dyrk1b	G	A	7: 28,182,687	D98N	probably benign	Het
Eif4g1	T	C	16: 20,692,417	S1550P	probably damaging	Het
Fam83e	A	G	7: 45,727,075	E404G	possibly damaging	Het
Fryl	G	A	5: 73,076,695	P1496S	probably benign	Het
Fsip1	A	T	2: 118,251,739	N71K	probably benign	Het
Gm5092	A	T	17: 21,094,708		noncoding transcript	Het
Gnb1l	T	A	16: 18,540,532		probably null	Het
Got1l1	T	C	8: 27,199,332	Y233C	probably damaging	Het
Katnbl1	T	A	2: 112,409,232		probably null	Het
Kcnn2	A	G	18: 45,685,315	E493G	probably damaging	Het
Kif26b	C	T	1: 178,874,128	R691W	probably damaging	Het
Lrp2	A	T	2: 69,455,452		probably benign	Het
Mast3	A	G	8: 70,789,217	S107P	probably damaging	Het
Mrc1	A	G	2: 14,331,101	N1433D	probably benign	Het
Mycbp2	G	A	14: 103,155,453	S3114L	probably benign	Het
Naip6	T	A	13: 100,316,424	H43L	possibly damaging	Het
Nin	A	T	12: 70,031,770	C1681S	probably damaging	Het
Nnmt	C	T	9: 48,592,052	V225M	probably damaging	Het
Olfr1233	A	T	2: 89,339,966	M112K	probably damaging	Het
Olfr694	A	T	7: 106,689,239	M164K	probably damaging	Het
Phf21a	T	G	2: 92,320,266	V64G	probably damaging	Het
Ptprd	A	T	4: 76,066,219	S800R	possibly damaging	Het
Scarf2	C	T	16: 17,807,549	P823S	probably benign	Het
Scn5a	T	C	9: 119,512,182	T1212A	possibly damaging	Het
Slc38a10	C	T	11: 120,105,119	V1043I	probably damaging	Het
Stxbp5	A	T	10: 9,816,290	L370Q	probably null	Het
Tas1r2	T	C	4: 139,669,156	V602A	possibly damaging	Het
Tatdn1	T	C	15: 58,916,196		probably benign	Het
Tdrd6	A	T	17: 43,625,507	L1550Q	probably damaging	Het
Tet3	G	T	6: 83,368,383	R1556S	probably damaging	Het
Tnpo2	T	A	8: 85,045,080	I249N	probably benign	Het
Tnxb	G	T	17: 34,713,595	V2263F	probably damaging	Het
Trim75	C	T	8: 64,983,340	V153M	possibly damaging	Het
Ttc21a	T	A	9: 119,943,976		probably null	Het
Tuft1	T	A	3: 94,634,514	I61L	possibly damaging	Het
Usp43	T	C	11: 67,876,489	D680G	probably damaging	Het
Vac14	A	G	8: 110,636,343	I274V	possibly damaging	Het
Vmn1r83	T	C	7: 12,321,690	M147V	probably benign	Het
Vmn2r43	T	A	7: 8,255,069	I382L	possibly damaging	Het
Vmn2r63	C	T	7: 42,903,454	V793I	probably damaging	Het
Vopp1	A	G	6: 57,762,507	Y19H	possibly damaging	Het
Yeats2	T	C	16: 20,229,573		probably null	Het

Other mutations in Vmn1r222

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01539:Vmn1r222	APN	13	23232889	missense	probably benign	0.45
IGL01960:Vmn1r222	APN	13	23232145	missense	probably benign	0.00
IGL02082:Vmn1r222	APN	13	23232329	missense	probably damaging	1.00
IGL02616:Vmn1r222	APN	13	23232141	missense	possibly damaging	0.73
IGL03333:Vmn1r222	APN	13	23233007	missense	probably benign	0.18
IGL03391:Vmn1r222	APN	13	23232462	missense	possibly damaging	0.94
R0137:Vmn1r222	UTSW	13	23232804	missense	probably damaging	1.00
R1584:Vmn1r222	UTSW	13	23232762	missense	probably damaging	1.00
R2352:Vmn1r222	UTSW	13	23232513	missense	probably benign	0.35
R3079:Vmn1r222	UTSW	13	23232461	missense	possibly damaging	0.75
R3080:Vmn1r222	UTSW	13	23232461	missense	possibly damaging	0.75
R3963:Vmn1r222	UTSW	13	23232932	missense	probably benign	0.01
R4448:Vmn1r222	UTSW	13	23232293	missense	probably benign	0.11
R4448:Vmn1r222	UTSW	13	23232660	missense	probably damaging	0.99
R4979:Vmn1r222	UTSW	13	23232432	missense	possibly damaging	0.78
R5054:Vmn1r222	UTSW	13	23232731	missense	probably damaging	0.98
R5182:Vmn1r222	UTSW	13	23232497	missense	probably damaging	1.00
R5230:Vmn1r222	UTSW	13	23233002	missense	probably benign
R5462:Vmn1r222	UTSW	13	23232875	missense	probably benign	0.05
R5611:Vmn1r222	UTSW	13	23232573	missense	probably damaging	1.00
R5677:Vmn1r222	UTSW	13	23232780	missense	probably damaging	1.00
R6298:Vmn1r222	UTSW	13	23232795	missense	probably benign	0.15
R6655:Vmn1r222	UTSW	13	23232716	missense	probably damaging	1.00
R6748:Vmn1r222	UTSW	13	23232947	missense	probably benign	0.00
R6912:Vmn1r222	UTSW	13	23232204	missense	probably benign	0.44
R7663:Vmn1r222	UTSW	13	23232431	missense	possibly damaging	0.78
R7764:Vmn1r222	UTSW	13	23232359	missense	probably damaging	1.00
R8675:Vmn1r222	UTSW	13	23232437	missense	probably damaging	1.00
R8774:Vmn1r222	UTSW	13	23232248	missense	probably benign	0.02
R8774-TAIL:Vmn1r222	UTSW	13	23232248	missense	probably benign	0.02
Z1177:Vmn1r222	UTSW	13	23232460	missense	possibly damaging	0.94

Posted On

2016-08-02