Incidental Mutation 'IGL03155:Yeats2'
ID 411253
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Yeats2
Ensembl Gene ENSMUSG00000041215
Gene Name YEATS domain containing 2
Synonyms
Accession Numbers

Ncbi RefSeq: NM_001145930.1, NM_001033237.2, NM_001145931.1; MGI:2447762

Is this an essential gene? Probably essential (E-score: 0.966) question?
Stock # IGL03155
Quality Score
Status
Chromosome 16
Chromosomal Location 20141063-20232573 bp(+) (GRCm38)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 20229573 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040880] [ENSMUST00000090052] [ENSMUST00000115560] [ENSMUST00000232019] [ENSMUST00000232338]
AlphaFold Q3TUF7
Predicted Effect probably benign
Transcript: ENSMUST00000040880
SMART Domains Protein: ENSMUSP00000043332
Gene: ENSMUSG00000041205

DomainStartEndE-ValueType
Pfam:STOP 1 191 1.5e-48 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000090052
SMART Domains Protein: ENSMUSP00000087506
Gene: ENSMUSG00000041215

DomainStartEndE-ValueType
Pfam:YEATS 179 262 2.6e-27 PFAM
low complexity region 299 309 N/A INTRINSIC
low complexity region 312 333 N/A INTRINSIC
low complexity region 409 429 N/A INTRINSIC
low complexity region 458 467 N/A INTRINSIC
internal_repeat_1 471 675 3.72e-6 PROSPERO
low complexity region 683 702 N/A INTRINSIC
low complexity region 738 775 N/A INTRINSIC
internal_repeat_1 785 978 3.72e-6 PROSPERO
low complexity region 1240 1249 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115560
SMART Domains Protein: ENSMUSP00000111222
Gene: ENSMUSG00000041215

DomainStartEndE-ValueType
Pfam:YEATS 232 314 2.1e-28 PFAM
low complexity region 352 362 N/A INTRINSIC
low complexity region 365 386 N/A INTRINSIC
low complexity region 462 482 N/A INTRINSIC
low complexity region 511 520 N/A INTRINSIC
internal_repeat_1 524 728 4.68e-6 PROSPERO
low complexity region 736 755 N/A INTRINSIC
low complexity region 791 828 N/A INTRINSIC
internal_repeat_1 838 1031 4.68e-6 PROSPERO
low complexity region 1293 1302 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231997
Predicted Effect probably null
Transcript: ENSMUST00000232019
Predicted Effect probably benign
Transcript: ENSMUST00000232338
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232671
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Allele List at MGI

All alleles(34) : Targeted(1) Gene trapped(33)

Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adra1d C T 2: 131,546,081 R518H probably benign Het
Akr7a5 T A 4: 139,314,526 C190* probably null Het
Cct2 A T 10: 117,060,671 L209Q probably damaging Het
Chordc1 T A 9: 18,304,320 S123T possibly damaging Het
Crtap T C 9: 114,380,049 D309G possibly damaging Het
Csf2 T C 11: 54,247,671 T115A possibly damaging Het
Dgkb T A 12: 38,139,459 I287N probably damaging Het
Dyrk1b G A 7: 28,182,687 D98N probably benign Het
Eif4g1 T C 16: 20,692,417 S1550P probably damaging Het
Fam83e A G 7: 45,727,075 E404G possibly damaging Het
Fryl G A 5: 73,076,695 P1496S probably benign Het
Fsip1 A T 2: 118,251,739 N71K probably benign Het
Gm5092 A T 17: 21,094,708 noncoding transcript Het
Gnb1l T A 16: 18,540,532 probably null Het
Got1l1 T C 8: 27,199,332 Y233C probably damaging Het
Katnbl1 T A 2: 112,409,232 probably null Het
Kcnn2 A G 18: 45,685,315 E493G probably damaging Het
Kif26b C T 1: 178,874,128 R691W probably damaging Het
Lrp2 A T 2: 69,455,452 probably benign Het
Mast3 A G 8: 70,789,217 S107P probably damaging Het
Mrc1 A G 2: 14,331,101 N1433D probably benign Het
Mycbp2 G A 14: 103,155,453 S3114L probably benign Het
Naip6 T A 13: 100,316,424 H43L possibly damaging Het
Nin A T 12: 70,031,770 C1681S probably damaging Het
Nnmt C T 9: 48,592,052 V225M probably damaging Het
Olfr1233 A T 2: 89,339,966 M112K probably damaging Het
Olfr694 A T 7: 106,689,239 M164K probably damaging Het
Phf21a T G 2: 92,320,266 V64G probably damaging Het
Ptprd A T 4: 76,066,219 S800R possibly damaging Het
Scarf2 C T 16: 17,807,549 P823S probably benign Het
Scn5a T C 9: 119,512,182 T1212A possibly damaging Het
Slc38a10 C T 11: 120,105,119 V1043I probably damaging Het
Stxbp5 A T 10: 9,816,290 L370Q probably null Het
Tas1r2 T C 4: 139,669,156 V602A possibly damaging Het
Tatdn1 T C 15: 58,916,196 probably benign Het
Tdrd6 A T 17: 43,625,507 L1550Q probably damaging Het
Tet3 G T 6: 83,368,383 R1556S probably damaging Het
Tnpo2 T A 8: 85,045,080 I249N probably benign Het
Tnxb G T 17: 34,713,595 V2263F probably damaging Het
Trim75 C T 8: 64,983,340 V153M possibly damaging Het
Ttc21a T A 9: 119,943,976 probably null Het
Tuft1 T A 3: 94,634,514 I61L possibly damaging Het
Usp43 T C 11: 67,876,489 D680G probably damaging Het
Vac14 A G 8: 110,636,343 I274V possibly damaging Het
Vmn1r222 T A 13: 23,232,693 R117W probably damaging Het
Vmn1r83 T C 7: 12,321,690 M147V probably benign Het
Vmn2r43 T A 7: 8,255,069 I382L possibly damaging Het
Vmn2r63 C T 7: 42,903,454 V793I probably damaging Het
Vopp1 A G 6: 57,762,507 Y19H possibly damaging Het
Other mutations in Yeats2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Yeats2 APN 16 20186304 missense probably damaging 0.99
IGL01128:Yeats2 APN 16 20161968 splice site probably benign
IGL01139:Yeats2 APN 16 20214393 missense probably damaging 1.00
IGL01394:Yeats2 APN 16 20162032 missense probably damaging 0.99
IGL01482:Yeats2 APN 16 20222921 missense probably damaging 1.00
IGL01924:Yeats2 APN 16 20206167 missense probably damaging 1.00
IGL01925:Yeats2 APN 16 20179680 splice site probably benign
IGL02106:Yeats2 APN 16 20193220 missense possibly damaging 0.79
IGL02370:Yeats2 APN 16 20150471 missense probably damaging 0.99
IGL02447:Yeats2 APN 16 20193679 missense probably benign 0.00
IGL02669:Yeats2 APN 16 20186283 missense probably benign 0.13
tyrion UTSW 16 20213401 splice site probably benign
P0045:Yeats2 UTSW 16 20156945 missense possibly damaging 0.47
R0051:Yeats2 UTSW 16 20193724 nonsense probably null
R0051:Yeats2 UTSW 16 20193724 nonsense probably null
R0118:Yeats2 UTSW 16 20156942 nonsense probably null
R0157:Yeats2 UTSW 16 20221677 makesense probably null
R0184:Yeats2 UTSW 16 20203685 missense possibly damaging 0.79
R0194:Yeats2 UTSW 16 20152969 start codon destroyed probably null 1.00
R0612:Yeats2 UTSW 16 20186425 missense probably benign 0.00
R0655:Yeats2 UTSW 16 20193824 nonsense probably null
R0826:Yeats2 UTSW 16 20193216 nonsense probably null
R1526:Yeats2 UTSW 16 20206086 missense probably damaging 1.00
R1535:Yeats2 UTSW 16 20189365 missense probably damaging 0.99
R1749:Yeats2 UTSW 16 20186268 nonsense probably null
R1842:Yeats2 UTSW 16 20171238 missense probably damaging 1.00
R1843:Yeats2 UTSW 16 20229564 missense probably benign 0.01
R1926:Yeats2 UTSW 16 20214426 missense probably benign
R2000:Yeats2 UTSW 16 20186391 missense probably benign 0.20
R2017:Yeats2 UTSW 16 20159181 missense probably benign 0.01
R2076:Yeats2 UTSW 16 20186282 missense possibly damaging 0.47
R2153:Yeats2 UTSW 16 20154166 missense probably damaging 1.00
R2167:Yeats2 UTSW 16 20213401 splice site probably benign
R2981:Yeats2 UTSW 16 20186301 missense probably damaging 0.99
R3160:Yeats2 UTSW 16 20193645 missense probably damaging 1.00
R3161:Yeats2 UTSW 16 20193645 missense probably damaging 1.00
R3162:Yeats2 UTSW 16 20193645 missense probably damaging 1.00
R3774:Yeats2 UTSW 16 20150495 missense probably damaging 1.00
R4250:Yeats2 UTSW 16 20156935 missense possibly damaging 0.90
R4305:Yeats2 UTSW 16 20208422 missense probably damaging 1.00
R4455:Yeats2 UTSW 16 20161993 missense possibly damaging 0.88
R4458:Yeats2 UTSW 16 20213321 missense probably damaging 0.99
R4811:Yeats2 UTSW 16 20152895 splice site probably null
R4902:Yeats2 UTSW 16 20207668 missense probably benign 0.00
R5043:Yeats2 UTSW 16 20208465 missense probably damaging 1.00
R5047:Yeats2 UTSW 16 20208465 missense probably damaging 1.00
R5319:Yeats2 UTSW 16 20186425 missense probably benign 0.01
R5328:Yeats2 UTSW 16 20171205 missense probably damaging 1.00
R5360:Yeats2 UTSW 16 20154162 missense probably damaging 0.97
R5416:Yeats2 UTSW 16 20211569 missense probably benign 0.01
R5672:Yeats2 UTSW 16 20162029 missense probably damaging 1.00
R5684:Yeats2 UTSW 16 20193803 missense possibly damaging 0.94
R5932:Yeats2 UTSW 16 20193163 missense probably benign 0.06
R5946:Yeats2 UTSW 16 20207763 nonsense probably null
R6168:Yeats2 UTSW 16 20179558 missense probably benign 0.01
R6169:Yeats2 UTSW 16 20219667 missense probably damaging 1.00
R6179:Yeats2 UTSW 16 20214475 missense probably benign 0.16
R6371:Yeats2 UTSW 16 20221710 missense possibly damaging 0.54
R6877:Yeats2 UTSW 16 20179594 missense probably benign 0.00
R7149:Yeats2 UTSW 16 20154189 missense probably damaging 1.00
R7405:Yeats2 UTSW 16 20222913 missense probably damaging 1.00
R8353:Yeats2 UTSW 16 20222887 nonsense probably null
R8367:Yeats2 UTSW 16 20222825 missense probably damaging 1.00
R8453:Yeats2 UTSW 16 20222887 nonsense probably null
R8506:Yeats2 UTSW 16 20152934 missense probably damaging 0.98
R8535:Yeats2 UTSW 16 20159176 missense probably damaging 1.00
R8828:Yeats2 UTSW 16 20150510 missense probably benign 0.45
R8905:Yeats2 UTSW 16 20190394 missense probably benign 0.02
R8924:Yeats2 UTSW 16 20150562 critical splice donor site probably null
R9087:Yeats2 UTSW 16 20211750 critical splice donor site probably null
R9276:Yeats2 UTSW 16 20157036 missense probably benign 0.34
R9338:Yeats2 UTSW 16 20213328 missense possibly damaging 0.69
R9338:Yeats2 UTSW 16 20222783 missense probably damaging 0.99
R9378:Yeats2 UTSW 16 20214478 missense probably benign
Posted On 2016-08-02