Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03156:Trmt13'

411262

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trmt13

Ensembl Gene

ENSMUSG00000033439

Gene Name

tRNA methyltransferase 13

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.143) question?

Stock #

IGL03156

Quality Score

Status

Chromosome

Chromosomal Location

116581093-116614587 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 116585802 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 232 (D232G)

Ref Sequence

ENSEMBL: ENSMUSP00000047320 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029573] [ENSMUST00000041524] [ENSMUST00000134761] [ENSMUST00000183638] [ENSMUST00000184963] [ENSMUST00000197190]

Predicted Effect

probably benign
Transcript: ENSMUST00000029573

SMART Domains

Protein: ENSMUSP00000029573
Gene: ENSMUSG00000027961

Domain	Start	End	E-Value	Type
LRR	105	127	1.15e1	SMART
LRR_TYP	128	151	7.26e-3	SMART
LRR	175	197	6.58e0	SMART
LRR	198	220	1e1	SMART
LRR	221	243	7.16e0	SMART
LRR	244	267	6.58e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000041524
AA Change: D232G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000047320
Gene: ENSMUSG00000033439
AA Change: D232G

Domain	Start	End	E-Value	Type
Pfam:zf-TRM13_CCCH	17	45	7.2e-17	PFAM
Pfam:zf-U11-48K	56	80	3.4e-12	PFAM
Pfam:TRM13	165	469	7e-96	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000134761

SMART Domains

Protein: ENSMUSP00000138761
Gene: ENSMUSG00000033439

Domain	Start	End	E-Value	Type
Pfam:zf-U11-48K	16	42	1.6e-13	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156161

Predicted Effect

probably benign
Transcript: ENSMUST00000183638

SMART Domains

Protein: ENSMUSP00000139223
Gene: ENSMUSG00000033439

Domain	Start	End	E-Value	Type
Pfam:zf-TRM13_CCCH	16	46	1.4e-17	PFAM
Pfam:zf-U11-48K	55	81	1.2e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000184963
AA Change: D232G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138868
Gene: ENSMUSG00000033439
AA Change: D232G

Domain	Start	End	E-Value	Type
Pfam:zf-TRM13_CCCH	16	46	2.9e-17	PFAM
Pfam:zf-U11-48K	55	81	2.3e-12	PFAM
Pfam:TRM13	165	285	3.4e-42	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000197190

SMART Domains

Protein: ENSMUSP00000143637
Gene: ENSMUSG00000033439

Domain	Start	End	E-Value	Type
Pfam:TRM13	116	179	5.2e-19	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199439

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017D01Rik	A	T	19: 11,105,750	I102K	possibly damaging	Het
4930430A15Rik	T	C	2: 111,200,412	D12G	possibly damaging	Het
Abca16	T	C	7: 120,423,851	I70T	possibly damaging	Het
Acot11	A	G	4: 106,754,136	Y365H	probably damaging	Het
Bdp1	A	G	13: 100,061,036	V947A	probably benign	Het
Ccdc159	G	T	9: 21,929,475	V113L	probably benign	Het
Cep350	T	C	1: 155,858,042	D3035G	probably damaging	Het
Clca1	T	A	3: 145,013,911	I433F	probably damaging	Het
Cntn5	T	C	9: 9,673,877	Y740C	probably damaging	Het
Dennd5a	C	A	7: 109,919,255		probably benign	Het
Des	G	A	1: 75,362,996	E333K	probably damaging	Het
Dnah7a	T	C	1: 53,605,824	R1018G	probably damaging	Het
Eif2b2	G	T	12: 85,219,721	A54S	probably damaging	Het
Gm7276	C	T	18: 77,185,603		probably benign	Het
Hsbp1l1	A	G	18: 80,235,519		probably benign	Het
Iars	G	A	13: 49,703,179	G303S	possibly damaging	Het
Il18r1	A	G	1: 40,498,368	E431G	possibly damaging	Het
Lrrc14b	A	G	13: 74,363,904	V19A	probably benign	Het
Map1lc3a	T	A	2: 155,277,009	I31N	probably damaging	Het
Obscn	T	C	11: 59,054,896	Y4163C	probably damaging	Het
Olfr478	T	A	7: 108,032,351		probably benign	Het
Pcsk1	A	G	13: 75,131,951	T632A	probably benign	Het
Ppp1r15a	A	G	7: 45,525,171	L71P	possibly damaging	Het
Ptgs2	T	G	1: 150,105,477	F504V	probably damaging	Het
Rimbp2	T	G	5: 128,771,757	R908S	probably damaging	Het
Rnh1	T	C	7: 141,163,183	N268S	probably damaging	Het
Sap30l	T	C	11: 57,806,168		probably null	Het
Scara3	C	T	14: 65,931,154	R338H	probably damaging	Het
Serpina12	T	C	12: 104,037,899	Y158C	probably damaging	Het
Tmem237	A	T	1: 59,109,127	D148E	probably damaging	Het
Zan	T	A	5: 137,463,939	T993S	unknown	Het
Zfp236	G	A	18: 82,680,702	L85F	probably damaging	Het
Zfp352	G	A	4: 90,224,087	D155N	possibly damaging	Het
Zfp867	T	C	11: 59,465,008		probably benign	Het
Zmiz2	T	C	11: 6,399,536	F399L	probably damaging	Het

Other mutations in Trmt13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00926:Trmt13	APN	3	116590235	nonsense	probably null
IGL01516:Trmt13	APN	3	116589810	unclassified	probably benign
IGL01732:Trmt13	APN	3	116581464	missense	probably damaging	1.00
IGL01783:Trmt13	APN	3	116582912	nonsense	probably null
IGL02470:Trmt13	APN	3	116590228	critical splice donor site	probably null
IGL02492:Trmt13	APN	3	116582543	missense	possibly damaging	0.53
IGL02531:Trmt13	APN	3	116592191	critical splice donor site	probably null
R0394:Trmt13	UTSW	3	116582650	missense	probably damaging	1.00
R0446:Trmt13	UTSW	3	116582626	missense	probably damaging	1.00
R2211:Trmt13	UTSW	3	116594754	missense	probably benign	0.00
R2942:Trmt13	UTSW	3	116585772	missense	probably damaging	1.00
R3124:Trmt13	UTSW	3	116590244	missense	probably benign	0.00
R3945:Trmt13	UTSW	3	116581518	missense	probably damaging	1.00
R3946:Trmt13	UTSW	3	116581518	missense	probably damaging	1.00
R4255:Trmt13	UTSW	3	116582688	nonsense	probably null
R4520:Trmt13	UTSW	3	116581613	splice site	probably null
R4609:Trmt13	UTSW	3	116594827	utr 5 prime	probably benign
R4678:Trmt13	UTSW	3	116589755	missense	probably damaging	1.00
R4679:Trmt13	UTSW	3	116589755	missense	probably damaging	1.00
R4703:Trmt13	UTSW	3	116594598	missense	probably benign	0.00
R6526:Trmt13	UTSW	3	116592215	missense	probably damaging	1.00
R7064:Trmt13	UTSW	3	116582697	missense	probably damaging	1.00
R7079:Trmt13	UTSW	3	116582831	missense	probably benign	0.00
R7308:Trmt13	UTSW	3	116594739	missense	probably benign	0.09
R8347:Trmt13	UTSW	3	116582768	missense	probably benign	0.00

Posted On

2016-08-02