Incidental Mutation 'IGL03156:Ccdc159'
ID411278
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccdc159
Ensembl Gene ENSMUSG00000006241
Gene Namecoiled-coil domain containing 159
Synonyms2510048L02Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03156
Quality Score
Status
Chromosome9
Chromosomal Location21927471-21935872 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 21929475 bp
ZygosityHeterozygous
Amino Acid Change Valine to Leucine at position 113 (V113L)
Ref Sequence ENSEMBL: ENSMUSP00000150744 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006403] [ENSMUST00000046831] [ENSMUST00000170304] [ENSMUST00000213698] [ENSMUST00000214569] [ENSMUST00000214734] [ENSMUST00000216710]
Predicted Effect probably benign
Transcript: ENSMUST00000006403
AA Change: V105L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000006403
Gene: ENSMUSG00000006241
AA Change: V105L

DomainStartEndE-ValueType
low complexity region 42 52 N/A INTRINSIC
coiled coil region 152 172 N/A INTRINSIC
low complexity region 217 227 N/A INTRINSIC
coiled coil region 261 288 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000046831
SMART Domains Protein: ENSMUSP00000048832
Gene: ENSMUSG00000040883

DomainStartEndE-ValueType
Pfam:DUF4149 17 119 1.2e-27 PFAM
transmembrane domain 164 186 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000170304
AA Change: V113L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000126474
Gene: ENSMUSG00000006241
AA Change: V113L

DomainStartEndE-ValueType
low complexity region 50 60 N/A INTRINSIC
coiled coil region 160 180 N/A INTRINSIC
low complexity region 225 235 N/A INTRINSIC
coiled coil region 269 296 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213698
Predicted Effect probably benign
Transcript: ENSMUST00000214569
Predicted Effect probably benign
Transcript: ENSMUST00000214734
AA Change: V113L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215650
Predicted Effect probably benign
Transcript: ENSMUST00000216710
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217263
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217589
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017D01Rik A T 19: 11,105,750 I102K possibly damaging Het
4930430A15Rik T C 2: 111,200,412 D12G possibly damaging Het
Abca16 T C 7: 120,423,851 I70T possibly damaging Het
Acot11 A G 4: 106,754,136 Y365H probably damaging Het
Bdp1 A G 13: 100,061,036 V947A probably benign Het
Cep350 T C 1: 155,858,042 D3035G probably damaging Het
Clca1 T A 3: 145,013,911 I433F probably damaging Het
Cntn5 T C 9: 9,673,877 Y740C probably damaging Het
Dennd5a C A 7: 109,919,255 probably benign Het
Des G A 1: 75,362,996 E333K probably damaging Het
Dnah7a T C 1: 53,605,824 R1018G probably damaging Het
Eif2b2 G T 12: 85,219,721 A54S probably damaging Het
Gm7276 C T 18: 77,185,603 probably benign Het
Hsbp1l1 A G 18: 80,235,519 probably benign Het
Iars G A 13: 49,703,179 G303S possibly damaging Het
Il18r1 A G 1: 40,498,368 E431G possibly damaging Het
Lrrc14b A G 13: 74,363,904 V19A probably benign Het
Map1lc3a T A 2: 155,277,009 I31N probably damaging Het
Obscn T C 11: 59,054,896 Y4163C probably damaging Het
Olfr478 T A 7: 108,032,351 probably benign Het
Pcsk1 A G 13: 75,131,951 T632A probably benign Het
Ppp1r15a A G 7: 45,525,171 L71P possibly damaging Het
Ptgs2 T G 1: 150,105,477 F504V probably damaging Het
Rimbp2 T G 5: 128,771,757 R908S probably damaging Het
Rnh1 T C 7: 141,163,183 N268S probably damaging Het
Sap30l T C 11: 57,806,168 probably null Het
Scara3 C T 14: 65,931,154 R338H probably damaging Het
Serpina12 T C 12: 104,037,899 Y158C probably damaging Het
Tmem237 A T 1: 59,109,127 D148E probably damaging Het
Trmt13 T C 3: 116,585,802 D232G probably benign Het
Zan T A 5: 137,463,939 T993S unknown Het
Zfp236 G A 18: 82,680,702 L85F probably damaging Het
Zfp352 G A 4: 90,224,087 D155N possibly damaging Het
Zfp867 T C 11: 59,465,008 probably benign Het
Zmiz2 T C 11: 6,399,536 F399L probably damaging Het
Other mutations in Ccdc159
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00425:Ccdc159 APN 9 21929469 missense possibly damaging 0.83
IGL02322:Ccdc159 APN 9 21929373 missense possibly damaging 0.46
IGL03382:Ccdc159 APN 9 21931696 splice site probably null
R1622:Ccdc159 UTSW 9 21929370 missense possibly damaging 0.66
R2076:Ccdc159 UTSW 9 21929506 splice site probably null
R3905:Ccdc159 UTSW 9 21934519 critical splice donor site probably null
R4083:Ccdc159 UTSW 9 21929403 missense possibly damaging 0.83
R4625:Ccdc159 UTSW 9 21929466 missense probably benign
R4700:Ccdc159 UTSW 9 21927731 splice site probably null
R5004:Ccdc159 UTSW 9 21932945 missense probably damaging 1.00
R5743:Ccdc159 UTSW 9 21929390 missense probably benign 0.19
R6245:Ccdc159 UTSW 9 21935568 missense probably damaging 0.99
R7263:Ccdc159 UTSW 9 21931711 missense probably benign 0.04
R8171:Ccdc159 UTSW 9 21933711 missense possibly damaging 0.82
Posted On2016-08-02