Incidental Mutation 'IGL03156:Olfr478'
ID411288
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr478
Ensembl Gene ENSMUSG00000094426
Gene Nameolfactory receptor 478
SynonymsGA_x6K02T2PBJ9-10361879-10360935, MOR204-13
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.136) question?
Stock #IGL03156
Quality Score
Status
Chromosome7
Chromosomal Location108029965-108033989 bp(-) (GRCm38)
Type of Mutationutr 5 prime
DNA Base Change (assembly) T to A at 108032351 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147713 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049719] [ENSMUST00000210173]
Predicted Effect probably benign
Transcript: ENSMUST00000049719
SMART Domains Protein: ENSMUSP00000058931
Gene: ENSMUSG00000094426

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.1e-54 PFAM
Pfam:7tm_1 44 293 1e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000210173
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017D01Rik A T 19: 11,105,750 I102K possibly damaging Het
4930430A15Rik T C 2: 111,200,412 D12G possibly damaging Het
Abca16 T C 7: 120,423,851 I70T possibly damaging Het
Acot11 A G 4: 106,754,136 Y365H probably damaging Het
Bdp1 A G 13: 100,061,036 V947A probably benign Het
Ccdc159 G T 9: 21,929,475 V113L probably benign Het
Cep350 T C 1: 155,858,042 D3035G probably damaging Het
Clca1 T A 3: 145,013,911 I433F probably damaging Het
Cntn5 T C 9: 9,673,877 Y740C probably damaging Het
Dennd5a C A 7: 109,919,255 probably benign Het
Des G A 1: 75,362,996 E333K probably damaging Het
Dnah7a T C 1: 53,605,824 R1018G probably damaging Het
Eif2b2 G T 12: 85,219,721 A54S probably damaging Het
Gm7276 C T 18: 77,185,603 probably benign Het
Hsbp1l1 A G 18: 80,235,519 probably benign Het
Iars G A 13: 49,703,179 G303S possibly damaging Het
Il18r1 A G 1: 40,498,368 E431G possibly damaging Het
Lrrc14b A G 13: 74,363,904 V19A probably benign Het
Map1lc3a T A 2: 155,277,009 I31N probably damaging Het
Obscn T C 11: 59,054,896 Y4163C probably damaging Het
Pcsk1 A G 13: 75,131,951 T632A probably benign Het
Ppp1r15a A G 7: 45,525,171 L71P possibly damaging Het
Ptgs2 T G 1: 150,105,477 F504V probably damaging Het
Rimbp2 T G 5: 128,771,757 R908S probably damaging Het
Rnh1 T C 7: 141,163,183 N268S probably damaging Het
Sap30l T C 11: 57,806,168 probably null Het
Scara3 C T 14: 65,931,154 R338H probably damaging Het
Serpina12 T C 12: 104,037,899 Y158C probably damaging Het
Tmem237 A T 1: 59,109,127 D148E probably damaging Het
Trmt13 T C 3: 116,585,802 D232G probably benign Het
Zan T A 5: 137,463,939 T993S unknown Het
Zfp236 G A 18: 82,680,702 L85F probably damaging Het
Zfp352 G A 4: 90,224,087 D155N possibly damaging Het
Zfp867 T C 11: 59,465,008 probably benign Het
Zmiz2 T C 11: 6,399,536 F399L probably damaging Het
Other mutations in Olfr478
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Olfr478 APN 7 108031680 missense probably damaging 1.00
IGL01457:Olfr478 APN 7 108032121 missense possibly damaging 0.90
IGL03271:Olfr478 APN 7 108031507 missense probably damaging 0.96
IGL03399:Olfr478 APN 7 108031582 missense probably benign 0.02
R0660:Olfr478 UTSW 7 108031615 missense probably damaging 1.00
R0722:Olfr478 UTSW 7 108032334 missense probably benign 0.00
R1468:Olfr478 UTSW 7 108032388 splice site probably null
R1468:Olfr478 UTSW 7 108032388 splice site probably null
R2172:Olfr478 UTSW 7 108031467 missense probably damaging 1.00
R4274:Olfr478 UTSW 7 108031544 missense probably benign 0.01
R5164:Olfr478 UTSW 7 108032280 missense possibly damaging 0.47
R5501:Olfr478 UTSW 7 108032153 nonsense probably null
R7586:Olfr478 UTSW 7 108031921 missense probably benign 0.00
R7846:Olfr478 UTSW 7 108031992 missense probably benign 0.21
R8005:Olfr478 UTSW 7 108032263 missense possibly damaging 0.54
R8444:Olfr478 UTSW 7 108031863 missense probably benign
Z1176:Olfr478 UTSW 7 108031446 missense probably damaging 1.00
Posted On2016-08-02