Incidental Mutation 'R0097:Vav2'
ID 41137
Institutional Source Beutler Lab
Gene Symbol Vav2
Ensembl Gene ENSMUSG00000009621
Gene Name vav 2 oncogene
Synonyms 2810040F13Rik
MMRRC Submission 038383-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.338) question?
Stock # R0097 (G1)
Quality Score 195
Status Validated
Chromosome 2
Chromosomal Location 27152116-27317045 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 27189374 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000138964 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056176] [ENSMUST00000185188]
AlphaFold Q60992
Predicted Effect probably benign
Transcript: ENSMUST00000056176
SMART Domains Protein: ENSMUSP00000062782
Gene: ENSMUSG00000009621

DomainStartEndE-ValueType
CH 3 115 1.87e-24 SMART
low complexity region 165 176 N/A INTRINSIC
RhoGEF 197 370 2.41e-57 SMART
PH 401 504 2.05e-10 SMART
C1 514 562 1.43e-11 SMART
SH3 579 641 1.26e-13 SMART
SH2 661 743 3.37e-25 SMART
low complexity region 759 777 N/A INTRINSIC
SH3 809 866 3.27e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132642
Predicted Effect probably benign
Transcript: ENSMUST00000185188
SMART Domains Protein: ENSMUSP00000138964
Gene: ENSMUSG00000009621

DomainStartEndE-ValueType
CH 3 129 3.71e-2 SMART
RhoGEF 163 336 2.41e-57 SMART
PH 367 475 1.78e-10 SMART
C1 485 533 1.43e-11 SMART
SH3 550 612 1.26e-13 SMART
SH2 632 714 1.26e-15 SMART
low complexity region 771 789 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.2%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Homozygous null mutants have defects in humoral immune response to type II thymus-independent antigens, in primary response to thymus-dependent antigens and inability to switch immunoglobulin class, form germinal centers and generate secondary responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A T 3: 124,206,129 (GRCm39) I353K probably benign Het
Albfm1 T A 5: 90,732,795 (GRCm39) S535R probably benign Het
Arfgap2 T A 2: 91,105,160 (GRCm39) V422E probably benign Het
Baz1b T C 5: 135,227,113 (GRCm39) S105P probably benign Het
Bbs10 T C 10: 111,134,705 (GRCm39) V41A probably damaging Het
Cacna1s T A 1: 136,028,360 (GRCm39) M899K possibly damaging Het
Ccnd2 G A 6: 127,123,015 (GRCm39) A180V probably benign Het
Ciao3 T C 17: 25,995,976 (GRCm39) S67P possibly damaging Het
Cldnd1 A G 16: 58,550,078 (GRCm39) N87S possibly damaging Het
Cyp2c54 T A 19: 40,036,102 (GRCm39) probably benign Het
Cyp2c54 G T 19: 40,036,103 (GRCm39) probably benign Het
Dab2ip G A 2: 35,608,928 (GRCm39) V629M possibly damaging Het
Ddx41 A T 13: 55,683,691 (GRCm39) probably benign Het
Dmrta1 A T 4: 89,577,109 (GRCm39) R188S probably benign Het
Eml3 T A 19: 8,914,015 (GRCm39) F465L probably benign Het
Gm9938 T A 19: 23,701,828 (GRCm39) probably benign Het
Gpr87 G A 3: 59,086,506 (GRCm39) T333I probably damaging Het
Krt81 C A 15: 101,361,508 (GRCm39) R24L possibly damaging Het
Llgl2 T A 11: 115,735,323 (GRCm39) Y59* probably null Het
Lzic A G 4: 149,572,533 (GRCm39) E41G probably damaging Het
Mprip T A 11: 59,649,317 (GRCm39) L1007Q possibly damaging Het
Mtfr2 T A 10: 20,224,122 (GRCm39) S19T probably damaging Het
Mycbp2 A T 14: 103,393,198 (GRCm39) M3121K probably damaging Het
Myocd T A 11: 65,069,840 (GRCm39) M667L possibly damaging Het
Ncam2 A G 16: 81,314,425 (GRCm39) D467G probably damaging Het
Neb T C 2: 52,094,906 (GRCm39) N4882S probably damaging Het
Neu2 A G 1: 87,525,188 (GRCm39) D391G probably benign Het
Nol4 C A 18: 22,852,198 (GRCm39) A456S probably benign Het
Or5m13 T C 2: 85,749,184 (GRCm39) V305A probably benign Het
Padi6 C T 4: 140,458,268 (GRCm39) V513M probably benign Het
Pign G A 1: 105,515,701 (GRCm39) probably benign Het
Plpp2 T C 10: 79,366,371 (GRCm39) E91G possibly damaging Het
Pnp T A 14: 51,188,873 (GRCm39) V222D probably damaging Het
Pnp2 C T 14: 51,200,958 (GRCm39) R148C probably benign Het
Pramel30 T C 4: 144,057,857 (GRCm39) S155P probably benign Het
Prss38 A G 11: 59,266,434 (GRCm39) L8S possibly damaging Het
Rab5b A T 10: 128,518,809 (GRCm39) F108I probably damaging Het
Rbbp5 T A 1: 132,418,227 (GRCm39) H15Q possibly damaging Het
Rhox4f A C X: 36,789,122 (GRCm39) V15G probably benign Het
Rsl1 A C 13: 67,329,966 (GRCm39) Q138P probably damaging Het
Ryr3 T C 2: 112,630,400 (GRCm39) D2157G probably damaging Het
Secisbp2l T C 2: 125,613,376 (GRCm39) D206G probably damaging Het
Sh3pxd2b T A 11: 32,353,978 (GRCm39) I182N probably damaging Het
Slc3a1 A T 17: 85,340,288 (GRCm39) I237F probably damaging Het
Svs3b T C 2: 164,098,159 (GRCm39) E54G probably damaging Het
T A T 17: 8,658,733 (GRCm39) probably benign Het
Tenm4 A T 7: 96,542,133 (GRCm39) D1882V probably damaging Het
Tgfbr1 T A 4: 47,403,451 (GRCm39) L283* probably null Het
Tppp3 C T 8: 106,194,554 (GRCm39) A149T probably benign Het
Ubp1 T C 9: 113,802,575 (GRCm39) probably benign Het
Ushbp1 C T 8: 71,843,357 (GRCm39) C314Y probably damaging Het
Vmn1r228 T C 17: 20,996,625 (GRCm39) M298V probably benign Het
Zmpste24 A T 4: 120,952,740 (GRCm39) probably benign Het
Other mutations in Vav2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00565:Vav2 APN 2 27,167,250 (GRCm39) missense probably benign 0.35
IGL02394:Vav2 APN 2 27,187,671 (GRCm39) splice site probably benign
IGL03088:Vav2 APN 2 27,157,262 (GRCm39) missense possibly damaging 0.74
IGL03256:Vav2 APN 2 27,161,912 (GRCm39) splice site probably null
IGL03295:Vav2 APN 2 27,165,041 (GRCm39) missense possibly damaging 0.90
Assent UTSW 2 27,186,231 (GRCm39) missense probably damaging 1.00
R0097:Vav2 UTSW 2 27,189,374 (GRCm39) splice site probably benign
R0140:Vav2 UTSW 2 27,163,688 (GRCm39) splice site probably benign
R0331:Vav2 UTSW 2 27,186,187 (GRCm39) missense probably benign 0.09
R0619:Vav2 UTSW 2 27,186,133 (GRCm39) critical splice donor site probably null
R1191:Vav2 UTSW 2 27,182,792 (GRCm39) splice site probably null
R1723:Vav2 UTSW 2 27,208,976 (GRCm39) missense possibly damaging 0.94
R2107:Vav2 UTSW 2 27,157,315 (GRCm39) missense probably damaging 1.00
R2131:Vav2 UTSW 2 27,189,408 (GRCm39) missense possibly damaging 0.71
R2164:Vav2 UTSW 2 27,163,718 (GRCm39) missense probably damaging 0.96
R2268:Vav2 UTSW 2 27,182,667 (GRCm39) splice site probably null
R2927:Vav2 UTSW 2 27,316,403 (GRCm39) missense probably damaging 1.00
R3802:Vav2 UTSW 2 27,157,235 (GRCm39) splice site probably benign
R4050:Vav2 UTSW 2 27,181,415 (GRCm39) missense probably damaging 1.00
R4050:Vav2 UTSW 2 27,178,691 (GRCm39) missense probably benign 0.01
R4626:Vav2 UTSW 2 27,160,172 (GRCm39) missense possibly damaging 0.62
R4895:Vav2 UTSW 2 27,208,973 (GRCm39) missense probably damaging 0.99
R5441:Vav2 UTSW 2 27,160,122 (GRCm39) intron probably benign
R6009:Vav2 UTSW 2 27,161,912 (GRCm39) splice site probably null
R6501:Vav2 UTSW 2 27,186,231 (GRCm39) missense probably damaging 1.00
R6564:Vav2 UTSW 2 27,169,197 (GRCm39) splice site probably null
R7206:Vav2 UTSW 2 27,226,731 (GRCm39) missense probably benign 0.17
R7267:Vav2 UTSW 2 27,173,334 (GRCm39) missense probably damaging 0.99
R7541:Vav2 UTSW 2 27,165,014 (GRCm39) missense probably damaging 0.99
R7691:Vav2 UTSW 2 27,187,750 (GRCm39) critical splice acceptor site probably null
R7786:Vav2 UTSW 2 27,276,613 (GRCm39) missense probably damaging 1.00
R7822:Vav2 UTSW 2 27,172,299 (GRCm39) critical splice donor site probably null
R8434:Vav2 UTSW 2 27,159,050 (GRCm39) intron probably benign
R8535:Vav2 UTSW 2 27,161,841 (GRCm39) missense probably damaging 1.00
R9015:Vav2 UTSW 2 27,160,151 (GRCm39) nonsense probably null
R9088:Vav2 UTSW 2 27,187,708 (GRCm39) missense possibly damaging 0.84
R9097:Vav2 UTSW 2 27,181,850 (GRCm39) missense probably damaging 1.00
R9180:Vav2 UTSW 2 27,182,701 (GRCm39) missense probably damaging 1.00
R9192:Vav2 UTSW 2 27,172,394 (GRCm39) missense probably damaging 1.00
R9493:Vav2 UTSW 2 27,157,276 (GRCm39) missense probably damaging 1.00
R9545:Vav2 UTSW 2 27,173,351 (GRCm39) missense probably damaging 1.00
R9711:Vav2 UTSW 2 27,159,027 (GRCm39) missense probably damaging 1.00
R9790:Vav2 UTSW 2 27,181,825 (GRCm39) missense probably damaging 1.00
R9791:Vav2 UTSW 2 27,181,825 (GRCm39) missense probably damaging 1.00
X0064:Vav2 UTSW 2 27,172,363 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGGGGCTGTTACCCCAGTGT -3'
(R):5'- CTGGAAAGGTGTCATCCTGTTGTGT -3'

Sequencing Primer
(F):5'- agagtcacgggaagggag -3'
(R):5'- TCATCCTGTTGTGTGGGAC -3'
Posted On 2013-05-23