Incidental Mutation 'R0097:Olfr1025-ps1'
ID41140
Institutional Source Beutler Lab
Gene Symbol Olfr1025-ps1
Ensembl Gene ENSMUSG00000058884
Gene Nameolfactory receptor 1025, pseudogene 1
SynonymsMOR196-6_p, GA_x6K02T2Q125-47397266-47398205, MOR196-5P
MMRRC Submission 038383-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.096) question?
Stock #R0097 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location85915193-85921381 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 85918840 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 305 (V305A)
Ref Sequence ENSEMBL: ENSMUSP00000149785 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056718] [ENSMUST00000188749] [ENSMUST00000213474] [ENSMUST00000217615] [ENSMUST00000219615]
Predicted Effect probably benign
Transcript: ENSMUST00000056718
SMART Domains Protein: ENSMUSP00000049887
Gene: ENSMUSG00000042863

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 6.1e-58 PFAM
Pfam:7tm_1 41 290 9e-25 PFAM
Predicted Effect
SMART Domains Protein: ENSMUSP00000076311
Gene: ENSMUSG00000058884
AA Change: V305A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-57 PFAM
Pfam:7tm_1 41 290 2.6e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000188749
AA Change: V305A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000139860
Gene: ENSMUSG00000058884
AA Change: V305A

DomainStartEndE-ValueType
low complexity region 26 40 N/A INTRINSIC
Pfam:7tm_1 41 290 5.7e-30 PFAM
Pfam:7tm_4 139 283 7.8e-48 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213474
AA Change: V305A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000217615
Predicted Effect probably benign
Transcript: ENSMUST00000219615
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.2%
Validation Efficiency 100% (57/57)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A T 3: 124,412,480 I353K probably benign Het
5830473C10Rik T A 5: 90,584,936 S535R probably benign Het
Arfgap2 T A 2: 91,274,815 V422E probably benign Het
Baz1b T C 5: 135,198,259 S105P probably benign Het
Bbs10 T C 10: 111,298,844 V41A probably damaging Het
Cacna1s T A 1: 136,100,622 M899K possibly damaging Het
Ccnd2 G A 6: 127,146,052 A180V probably benign Het
Cldnd1 A G 16: 58,729,715 N87S possibly damaging Het
Cyp2c54 T A 19: 40,047,658 probably benign Het
Cyp2c54 G T 19: 40,047,659 probably benign Het
Dab2ip G A 2: 35,718,916 V629M possibly damaging Het
Ddx41 A T 13: 55,535,878 probably benign Het
Dmrta1 A T 4: 89,688,872 R188S probably benign Het
Eml3 T A 19: 8,936,651 F465L probably benign Het
Gm13128 T C 4: 144,331,287 S155P probably benign Het
Gm9938 T A 19: 23,724,464 probably benign Het
Gpr87 G A 3: 59,179,085 T333I probably damaging Het
Krt81 C A 15: 101,463,627 R24L possibly damaging Het
Llgl2 T A 11: 115,844,497 Y59* probably null Het
Lzic A G 4: 149,488,076 E41G probably damaging Het
Mprip T A 11: 59,758,491 L1007Q possibly damaging Het
Mtfr2 T A 10: 20,348,376 S19T probably damaging Het
Mycbp2 A T 14: 103,155,762 M3121K probably damaging Het
Myocd T A 11: 65,179,014 M667L possibly damaging Het
Narfl T C 17: 25,777,002 S67P possibly damaging Het
Ncam2 A G 16: 81,517,537 D467G probably damaging Het
Neb T C 2: 52,204,894 N4882S probably damaging Het
Neu2 A G 1: 87,597,466 D391G probably benign Het
Nol4 C A 18: 22,719,141 A456S probably benign Het
Padi6 C T 4: 140,730,957 V513M probably benign Het
Pign G A 1: 105,587,976 probably benign Het
Plpp2 T C 10: 79,530,537 E91G possibly damaging Het
Pnp T A 14: 50,951,416 V222D probably damaging Het
Pnp2 C T 14: 50,963,501 R148C probably benign Het
Prss38 A G 11: 59,375,608 L8S possibly damaging Het
Rab5b A T 10: 128,682,940 F108I probably damaging Het
Rbbp5 T A 1: 132,490,489 H15Q possibly damaging Het
Rhox4f A C X: 37,607,469 V15G probably benign Het
Rsl1 A C 13: 67,181,902 Q138P probably damaging Het
Ryr3 T C 2: 112,800,055 D2157G probably damaging Het
Secisbp2l T C 2: 125,771,456 D206G probably damaging Het
Sh3pxd2b T A 11: 32,403,978 I182N probably damaging Het
Slc3a1 A T 17: 85,032,860 I237F probably damaging Het
Svs3b T C 2: 164,256,239 E54G probably damaging Het
T A T 17: 8,439,901 probably benign Het
Tenm4 A T 7: 96,892,926 D1882V probably damaging Het
Tgfbr1 T A 4: 47,403,451 L283* probably null Het
Tppp3 C T 8: 105,467,922 A149T probably benign Het
Ubp1 T C 9: 113,973,507 probably benign Het
Ushbp1 C T 8: 71,390,713 C314Y probably damaging Het
Vav2 A T 2: 27,299,362 probably benign Het
Vmn1r228 T C 17: 20,776,363 M298V probably benign Het
Zmpste24 A T 4: 121,095,543 probably benign Het
Other mutations in Olfr1025-ps1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01660:Olfr1025-ps1 APN 2 85918564 missense probably benign 0.25
IGL02881:Olfr1025-ps1 APN 2 85918116 missense probably benign 0.00
R0097:Olfr1025-ps1 UTSW 2 85918840 missense probably benign 0.00
R0324:Olfr1025-ps1 UTSW 2 85917951 missense probably benign 0.22
R0392:Olfr1025-ps1 UTSW 2 85918762 missense possibly damaging 0.81
R0765:Olfr1025-ps1 UTSW 2 85918705 missense probably damaging 0.99
R1199:Olfr1025-ps1 UTSW 2 85918035 missense probably benign 0.00
R1894:Olfr1025-ps1 UTSW 2 85918255 missense probably benign 0.28
R2027:Olfr1025-ps1 UTSW 2 85918770 missense probably damaging 0.99
R2141:Olfr1025-ps1 UTSW 2 85918827 missense probably null
R3871:Olfr1025-ps1 UTSW 2 85918582 splice site probably null
R4837:Olfr1025-ps1 UTSW 2 85918404 missense probably benign 0.00
R4945:Olfr1025-ps1 UTSW 2 85918573 missense possibly damaging 0.81
R5056:Olfr1025-ps1 UTSW 2 85918136 missense probably damaging 1.00
R5441:Olfr1025-ps1 UTSW 2 85918590 missense probably benign 0.01
R5960:Olfr1025-ps1 UTSW 2 85918725 missense probably benign 0.07
R6807:Olfr1025-ps1 UTSW 2 85918038 missense possibly damaging 0.48
R7320:Olfr1025-ps1 UTSW 2 85918374 missense probably benign 0.00
R8523:Olfr1025-ps1 UTSW 2 85918063 missense probably damaging 0.97
V1662:Olfr1025-ps1 UTSW 2 85918594 missense probably benign 0.10
Z1176:Olfr1025-ps1 UTSW 2 85918501 missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TACAGCCATCCTGCGAATCCGTTC -3'
(R):5'- AGTCTACCTTTGCCAAAACAGCTCC -3'

Sequencing Primer
(F):5'- CAGAAGGGAGGCGCAAG -3'
(R):5'- ATAGAGTAATAGCAATATGTCTGTGC -3'
Posted On2013-05-23