Incidental Mutation 'IGL03162:Vpreb3'
ID 411463
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vpreb3
Ensembl Gene ENSMUSG00000000903
Gene Name V-set pre-B cell surrogate light chain 3
Synonyms 8HS-20, Vpreb-3
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03162
Quality Score
Status
Chromosome 10
Chromosomal Location 75778891-75785491 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 75785133 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 77 (Y77C)
Ref Sequence ENSEMBL: ENSMUSP00000113205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000926] [ENSMUST00000121151]
AlphaFold D3Z6J4
Predicted Effect probably damaging
Transcript: ENSMUST00000000926
AA Change: Y70C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000000926
Gene: ENSMUSG00000000903
AA Change: Y70C

DomainStartEndE-ValueType
IGv 36 117 1.81e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117331
Predicted Effect probably damaging
Transcript: ENSMUST00000121151
AA Change: Y77C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113205
Gene: ENSMUSG00000000903
AA Change: Y77C

DomainStartEndE-ValueType
IGv 43 124 1.81e-10 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg T A 15: 60,791,581 (GRCm39) D92V probably damaging Het
Acsl3 T C 1: 78,676,887 (GRCm39) probably null Het
Adam5 T C 8: 25,271,620 (GRCm39) T596A probably benign Het
Adh6a T A 3: 138,034,880 (GRCm39) Y336* probably null Het
Ak3 A T 19: 29,000,236 (GRCm39) V225D possibly damaging Het
Aldh1a7 T A 19: 20,685,645 (GRCm39) I302F probably benign Het
Amdhd1 T C 10: 93,367,337 (GRCm39) probably null Het
Arhgef18 G A 8: 3,491,301 (GRCm39) probably null Het
Caap1 A T 4: 94,389,261 (GRCm39) probably benign Het
Cdhr4 G A 9: 107,875,210 (GRCm39) G70D probably damaging Het
Celsr3 T C 9: 108,719,757 (GRCm39) F2445S probably damaging Het
Cenpc1 A G 5: 86,185,764 (GRCm39) V249A possibly damaging Het
Clca3a2 C A 3: 144,512,177 (GRCm39) V80F probably damaging Het
Col6a1 T A 10: 76,553,885 (GRCm39) probably benign Het
Commd10 T A 18: 47,220,117 (GRCm39) L198Q probably damaging Het
Cyp2d40 A G 15: 82,644,243 (GRCm39) L294P unknown Het
E2f6 T A 12: 16,868,909 (GRCm39) D77E probably benign Het
Elf5 T A 2: 103,260,751 (GRCm39) H38Q possibly damaging Het
Entrep1 T G 19: 23,965,824 (GRCm39) H225P probably damaging Het
Fcrl6 A G 1: 172,425,820 (GRCm39) V227A probably damaging Het
Fhip2b G T 14: 70,824,994 (GRCm39) D447E probably damaging Het
Gabarapl2 T A 8: 112,669,168 (GRCm39) V42D probably benign Het
Gm3543 A G 14: 41,802,022 (GRCm39) I154T possibly damaging Het
Gpr150 T A 13: 76,204,950 (GRCm39) probably benign Het
Gstp3 A G 19: 4,109,255 (GRCm39) probably benign Het
Gzmm C T 10: 79,528,790 (GRCm39) T64I probably damaging Het
Hs3st1 T A 5: 39,771,792 (GRCm39) K284* probably null Het
Ints7 A G 1: 191,353,524 (GRCm39) probably benign Het
Itih2 A T 2: 10,131,055 (GRCm39) I94N probably damaging Het
Kif26b A G 1: 178,744,497 (GRCm39) N1531S probably benign Het
Kif27 T C 13: 58,459,021 (GRCm39) S937G probably benign Het
Klhl2 A G 8: 65,207,426 (GRCm39) V311A probably damaging Het
Klrb1b T A 6: 128,795,892 (GRCm39) Q109L probably null Het
Lrig2 A G 3: 104,371,613 (GRCm39) F697L probably damaging Het
Lrrc66 T C 5: 73,764,725 (GRCm39) R773G probably benign Het
Mrgpra2b C T 7: 47,113,815 (GRCm39) V306I probably benign Het
Nipbl T C 15: 8,368,463 (GRCm39) H1127R probably benign Het
Nr3c2 A T 8: 77,944,213 (GRCm39) D816V probably damaging Het
Ntmt2 T A 1: 163,530,783 (GRCm39) I219L probably damaging Het
Or10a3 T C 7: 108,480,811 (GRCm39) M1V probably null Het
Or5w19 A C 2: 87,698,484 (GRCm39) M50L probably benign Het
Pdxdc1 A G 16: 13,675,281 (GRCm39) L350P probably damaging Het
Pkd1l2 G A 8: 117,792,484 (GRCm39) T436I probably benign Het
Pnpla7 T C 2: 24,905,301 (GRCm39) probably benign Het
Ppan T G 9: 20,802,608 (GRCm39) L283R probably damaging Het
Rbfox3 A C 11: 118,387,257 (GRCm39) S286A probably benign Het
Rbl2 A G 8: 91,812,330 (GRCm39) T273A probably benign Het
Recql4 G T 15: 76,590,296 (GRCm39) probably null Het
Slc22a26 T A 19: 7,779,466 (GRCm39) M117L probably benign Het
Sult2a2 T A 7: 13,468,822 (GRCm39) I96K probably damaging Het
Tcf15 G A 2: 151,990,626 (GRCm39) R175H probably benign Het
Uggt1 A T 1: 36,247,037 (GRCm39) V320D probably damaging Het
Vmn2r102 A G 17: 19,914,286 (GRCm39) N617S probably damaging Het
Zbbx A T 3: 74,978,930 (GRCm39) probably benign Het
Zfand6 A T 7: 84,283,185 (GRCm39) S57R probably benign Het
Zmym2 A G 14: 57,151,500 (GRCm39) I462V probably benign Het
Other mutations in Vpreb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Vpreb3 APN 10 75,784,231 (GRCm39) missense probably benign
IGL02051:Vpreb3 APN 10 75,784,244 (GRCm39) critical splice donor site probably null
R2319:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R2891:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R2892:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R2894:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R3438:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R3439:Vpreb3 UTSW 10 75,779,056 (GRCm39) unclassified probably benign
R3508:Vpreb3 UTSW 10 75,785,037 (GRCm39) missense probably benign 0.26
R3725:Vpreb3 UTSW 10 75,779,125 (GRCm39) critical splice donor site probably null
R3726:Vpreb3 UTSW 10 75,779,125 (GRCm39) critical splice donor site probably null
R3771:Vpreb3 UTSW 10 75,775,800 (GRCm39) missense probably benign 0.00
R4975:Vpreb3 UTSW 10 75,775,636 (GRCm39) missense probably damaging 1.00
Z1177:Vpreb3 UTSW 10 75,785,027 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02