Incidental Mutation 'IGL03163:Trcg1'
ID411500
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trcg1
Ensembl Gene ENSMUSG00000070298
Gene Nametaste receptor cell gene 1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #IGL03163
Quality Score
Status
Chromosome9
Chromosomal Location57236556-57249864 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 57248347 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 761 (L761P)
Ref Sequence ENSEMBL: ENSMUSP00000091357 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034846] [ENSMUST00000093837]
Predicted Effect probably benign
Transcript: ENSMUST00000034846
SMART Domains Protein: ENSMUSP00000034846
Gene: ENSMUSG00000032300

DomainStartEndE-ValueType
low complexity region 265 284 N/A INTRINSIC
low complexity region 293 299 N/A INTRINSIC
low complexity region 334 347 N/A INTRINSIC
low complexity region 649 675 N/A INTRINSIC
low complexity region 692 728 N/A INTRINSIC
low complexity region 785 799 N/A INTRINSIC
low complexity region 933 951 N/A INTRINSIC
low complexity region 963 977 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000093837
AA Change: L761P

PolyPhen 2 Score 0.924 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000091357
Gene: ENSMUSG00000070298
AA Change: L761P

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 302 335 N/A INTRINSIC
Blast:SEA 449 549 5e-21 BLAST
low complexity region 580 594 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 T A 12: 80,181,417 D393V probably benign Het
Amz2 C A 11: 109,428,925 Q46K probably benign Het
Ankhd1 G A 18: 36,647,628 R1911H probably damaging Het
Apba3 A G 10: 81,269,223 probably null Het
Atxn1l T C 8: 109,732,385 N415S probably damaging Het
Ccdc36 G T 9: 108,404,933 L519I probably benign Het
Clu C T 14: 65,979,786 S356F probably benign Het
Cluh T C 11: 74,666,068 V1029A probably benign Het
Creb3 C T 4: 43,566,315 L274F probably damaging Het
Cyhr1 A T 15: 76,659,274 L13Q probably damaging Het
Dcaf8 T C 1: 172,172,908 V211A probably damaging Het
Emilin3 G A 2: 160,908,729 Q320* probably null Het
Fam131c T C 4: 141,382,758 F156L probably damaging Het
Fbxw21 T A 9: 109,145,484 I323F probably benign Het
Fmo9 A G 1: 166,674,450 V202A possibly damaging Het
Gipr C T 7: 19,162,556 W205* probably null Het
Gm13941 A T 2: 111,098,416 I99K unknown Het
Gpr22 A T 12: 31,709,172 V317E possibly damaging Het
Hace1 T C 10: 45,672,605 I582T probably damaging Het
Khdrbs1 T C 4: 129,725,715 E211G probably benign Het
Lonrf1 T C 8: 36,230,330 D500G probably benign Het
Lrp2 A C 2: 69,501,526 Y1628* probably null Het
Lrrc40 T C 3: 158,041,587 I112T possibly damaging Het
Matr3 G A 18: 35,572,591 D190N probably damaging Het
Olfr894 T C 9: 38,219,414 V194A probably benign Het
Ptpn13 A T 5: 103,591,346 D2326V probably damaging Het
Ptpn3 T C 4: 57,222,020 D557G probably damaging Het
Rangap1 A T 15: 81,716,600 N194K probably damaging Het
Rasgef1c T C 11: 49,971,373 V363A possibly damaging Het
Ric8b A G 10: 85,001,822 N498D probably damaging Het
Scn1a A C 2: 66,318,074 D22E probably benign Het
Spc25 T G 2: 69,197,204 I115L probably damaging Het
Sspo A G 6: 48,484,332 H3569R probably benign Het
Stra6l T C 4: 45,881,455 I439T probably benign Het
Trappc12 G T 12: 28,746,654 P293Q probably damaging Het
Usp15 A C 10: 123,171,144 M144R probably damaging Het
Vmn2r11 T C 5: 109,053,826 I271V probably benign Het
Zcchc2 T C 1: 106,031,111 V1104A probably damaging Het
Other mutations in Trcg1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01727:Trcg1 APN 9 57242273 missense probably benign
IGL01727:Trcg1 APN 9 57242594 missense probably damaging 0.97
IGL02147:Trcg1 APN 9 57245849 missense probably benign 0.20
IGL02329:Trcg1 APN 9 57240393 missense possibly damaging 0.92
IGL02658:Trcg1 APN 9 57242228 nonsense probably null
IGL02852:Trcg1 APN 9 57241312 missense possibly damaging 0.94
FR4589:Trcg1 UTSW 9 57242202 frame shift probably null
R0555:Trcg1 UTSW 9 57242333 missense probably damaging 1.00
R0747:Trcg1 UTSW 9 57241921 missense probably benign 0.00
R1061:Trcg1 UTSW 9 57245873 missense possibly damaging 0.66
R1521:Trcg1 UTSW 9 57242465 missense probably benign 0.36
R1622:Trcg1 UTSW 9 57248672 missense possibly damaging 0.94
R1652:Trcg1 UTSW 9 57245573 missense probably damaging 0.99
R4677:Trcg1 UTSW 9 57245861 missense possibly damaging 0.94
R4879:Trcg1 UTSW 9 57246720 missense probably damaging 0.99
R5013:Trcg1 UTSW 9 57242279 missense probably damaging 0.99
R5141:Trcg1 UTSW 9 57241304 missense probably damaging 1.00
R5690:Trcg1 UTSW 9 57241811 missense probably benign 0.36
R6416:Trcg1 UTSW 9 57241330 missense possibly damaging 0.46
R6980:Trcg1 UTSW 9 57245573 missense probably damaging 0.99
R7022:Trcg1 UTSW 9 57241569 missense possibly damaging 0.46
R7172:Trcg1 UTSW 9 57248335 missense probably benign 0.01
R7276:Trcg1 UTSW 9 57242579 missense probably damaging 0.99
R7412:Trcg1 UTSW 9 57241483 missense probably benign 0.00
R7546:Trcg1 UTSW 9 57248338 missense probably benign 0.34
Posted On2016-08-02