Incidental Mutation 'IGL03163:Fmo9'
ID411524
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fmo9
Ensembl Gene ENSMUSG00000026560
Gene Nameflavin containing monooxygenase 9
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #IGL03163
Quality Score
Status
Chromosome1
Chromosomal Location166662055-166681845 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 166674450 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 202 (V202A)
Ref Sequence ENSEMBL: ENSMUSP00000027843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027843] [ENSMUST00000148677]
Predicted Effect possibly damaging
Transcript: ENSMUST00000027843
AA Change: V202A

PolyPhen 2 Score 0.772 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000027843
Gene: ENSMUSG00000026560
AA Change: V202A

DomainStartEndE-ValueType
Pfam:FMO-like 3 535 1.2e-252 PFAM
Pfam:Pyr_redox_2 4 262 2.9e-12 PFAM
Pfam:Pyr_redox_3 7 221 2.3e-14 PFAM
Pfam:NAD_binding_8 8 83 1.2e-6 PFAM
Pfam:K_oxygenase 77 334 8.9e-11 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000148677
AA Change: V151A

PolyPhen 2 Score 0.733 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000114750
Gene: ENSMUSG00000026560
AA Change: V151A

DomainStartEndE-ValueType
Pfam:FMO-like 1 484 1.6e-222 PFAM
Pfam:Pyr_redox_3 3 170 1.2e-12 PFAM
Pfam:K_oxygenase 28 283 6.2e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 T A 12: 80,181,417 D393V probably benign Het
Amz2 C A 11: 109,428,925 Q46K probably benign Het
Ankhd1 G A 18: 36,647,628 R1911H probably damaging Het
Apba3 A G 10: 81,269,223 probably null Het
Atxn1l T C 8: 109,732,385 N415S probably damaging Het
Ccdc36 G T 9: 108,404,933 L519I probably benign Het
Clu C T 14: 65,979,786 S356F probably benign Het
Cluh T C 11: 74,666,068 V1029A probably benign Het
Creb3 C T 4: 43,566,315 L274F probably damaging Het
Cyhr1 A T 15: 76,659,274 L13Q probably damaging Het
Dcaf8 T C 1: 172,172,908 V211A probably damaging Het
Emilin3 G A 2: 160,908,729 Q320* probably null Het
Fam131c T C 4: 141,382,758 F156L probably damaging Het
Fbxw21 T A 9: 109,145,484 I323F probably benign Het
Gipr C T 7: 19,162,556 W205* probably null Het
Gm13941 A T 2: 111,098,416 I99K unknown Het
Gpr22 A T 12: 31,709,172 V317E possibly damaging Het
Hace1 T C 10: 45,672,605 I582T probably damaging Het
Khdrbs1 T C 4: 129,725,715 E211G probably benign Het
Lonrf1 T C 8: 36,230,330 D500G probably benign Het
Lrp2 A C 2: 69,501,526 Y1628* probably null Het
Lrrc40 T C 3: 158,041,587 I112T possibly damaging Het
Matr3 G A 18: 35,572,591 D190N probably damaging Het
Olfr894 T C 9: 38,219,414 V194A probably benign Het
Ptpn13 A T 5: 103,591,346 D2326V probably damaging Het
Ptpn3 T C 4: 57,222,020 D557G probably damaging Het
Rangap1 A T 15: 81,716,600 N194K probably damaging Het
Rasgef1c T C 11: 49,971,373 V363A possibly damaging Het
Ric8b A G 10: 85,001,822 N498D probably damaging Het
Scn1a A C 2: 66,318,074 D22E probably benign Het
Spc25 T G 2: 69,197,204 I115L probably damaging Het
Sspo A G 6: 48,484,332 H3569R probably benign Het
Stra6l T C 4: 45,881,455 I439T probably benign Het
Trappc12 G T 12: 28,746,654 P293Q probably damaging Het
Trcg1 T C 9: 57,248,347 L761P possibly damaging Het
Usp15 A C 10: 123,171,144 M144R probably damaging Het
Vmn2r11 T C 5: 109,053,826 I271V probably benign Het
Zcchc2 T C 1: 106,031,111 V1104A probably damaging Het
Other mutations in Fmo9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Fmo9 APN 1 166680145 splice site probably null
IGL01796:Fmo9 APN 1 166663335 missense probably benign 0.31
IGL03005:Fmo9 APN 1 166674519 missense probably benign 0.02
IGL03115:Fmo9 APN 1 166677651 missense probably damaging 1.00
R0089:Fmo9 UTSW 1 166667309 missense probably benign 0.05
R0570:Fmo9 UTSW 1 166674462 missense probably null 0.00
R1520:Fmo9 UTSW 1 166667455 missense probably benign 0.19
R1779:Fmo9 UTSW 1 166663299 missense probably benign 0.18
R1783:Fmo9 UTSW 1 166673648 missense probably benign 0.01
R2858:Fmo9 UTSW 1 166673667 missense probably damaging 1.00
R2859:Fmo9 UTSW 1 166673667 missense probably damaging 1.00
R3851:Fmo9 UTSW 1 166663367 missense probably benign 0.00
R3924:Fmo9 UTSW 1 166664652 missense probably benign 0.03
R4470:Fmo9 UTSW 1 166680230 missense probably damaging 1.00
R4728:Fmo9 UTSW 1 166663311 missense possibly damaging 0.82
R5538:Fmo9 UTSW 1 166673629 missense probably benign 0.01
R5650:Fmo9 UTSW 1 166663446 missense probably damaging 1.00
R5820:Fmo9 UTSW 1 166664601 missense possibly damaging 0.67
R6163:Fmo9 UTSW 1 166667393 missense probably benign
R6229:Fmo9 UTSW 1 166677557 missense possibly damaging 0.64
R6243:Fmo9 UTSW 1 166667369 missense probably benign 0.45
R6375:Fmo9 UTSW 1 166664595 critical splice donor site probably null
R7144:Fmo9 UTSW 1 166677620 missense probably benign 0.40
R7236:Fmo9 UTSW 1 166676571 missense probably damaging 1.00
R7316:Fmo9 UTSW 1 166663646 missense probably benign 0.21
R7341:Fmo9 UTSW 1 166676546 missense probably damaging 1.00
R7382:Fmo9 UTSW 1 166663660 splice site probably null
R7589:Fmo9 UTSW 1 166674428 missense possibly damaging 0.61
R7679:Fmo9 UTSW 1 166667489 missense probably benign 0.01
R8110:Fmo9 UTSW 1 166663526 missense probably benign 0.03
Z1088:Fmo9 UTSW 1 166673545 critical splice donor site probably null
Posted On2016-08-02