Incidental Mutation 'IGL03165:Igkv4-74'
ID 411610
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igkv4-74
Ensembl Gene ENSMUSG00000076543
Gene Name immunoglobulin kappa variable 4-74
Synonyms Gm10880, 236047
Accession Numbers
Is this an essential gene? Not available question?
Stock # IGL03165
Quality Score
Status
Chromosome 6
Chromosomal Location 69184826-69185361 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 69185305 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000100145 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103344]
AlphaFold A0A0B4J1I3
Predicted Effect probably benign
Transcript: ENSMUST00000103344
SMART Domains Protein: ENSMUSP00000100145
Gene: ENSMUSG00000076543

DomainStartEndE-ValueType
IGv 40 113 3.99e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196767
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 T C 1: 25,094,394 I334V probably benign Het
Axdnd1 T A 1: 156,378,389 Y519F probably benign Het
C4b A G 17: 34,739,955 F500S probably benign Het
Cacng2 A T 15: 77,995,663 I153N possibly damaging Het
Ces1d T A 8: 93,189,519 H160L probably benign Het
Cnnm3 T G 1: 36,525,232 probably benign Het
Ctnna3 A G 10: 64,945,941 T728A probably damaging Het
Cyp2g1 G A 7: 26,809,776 V92M possibly damaging Het
Dock2 C A 11: 34,687,533 V35F probably damaging Het
Eif2a C A 3: 58,548,628 Y349* probably null Het
Erp44 C T 4: 48,236,872 probably null Het
Flg2 C T 3: 93,214,611 H1363Y unknown Het
Flnc G T 6: 29,449,378 G1425W probably damaging Het
Frem3 A G 8: 80,612,529 N484D probably benign Het
Fstl3 A G 10: 79,779,965 D95G probably benign Het
Gldc A G 19: 30,098,993 S1018P possibly damaging Het
Gstk1 T G 6: 42,249,434 I159S probably benign Het
Herc2 A G 7: 56,191,912 E3513G probably damaging Het
Hpca A T 4: 129,118,590 I51N probably damaging Het
Hsd17b7 C T 1: 169,953,080 E320K probably damaging Het
Kdm7a C A 6: 39,170,914 probably benign Het
Olfr1040 A C 2: 86,146,068 L222R possibly damaging Het
Olfr382 A T 11: 73,516,884 L105* probably null Het
Olfr619 T C 7: 103,604,011 I119T probably damaging Het
Pa2g4 A T 10: 128,559,060 probably null Het
Pdlim3 T A 8: 45,918,998 L360Q possibly damaging Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Polk T A 13: 96,516,688 Q68L probably benign Het
Ppfia2 T G 10: 106,767,487 L195R probably damaging Het
Ranbp1 A T 16: 18,247,281 probably benign Het
Rbm12b1 A G 4: 12,145,845 R606G possibly damaging Het
Ryr1 A G 7: 29,105,040 V488A probably benign Het
Sall2 A T 14: 52,314,168 D521E probably damaging Het
Sntg1 A T 1: 8,445,104 C402S probably damaging Het
Spg7 T C 8: 123,080,812 probably null Het
Stk31 G A 6: 49,445,264 E750K probably damaging Het
Tlr2 A G 3: 83,837,948 I276T probably benign Het
Trav12-2 A T 14: 53,616,749 H60L probably benign Het
Urb1 A G 16: 90,780,304 L775S probably damaging Het
Utp14b A G 1: 78,664,520 D45G probably damaging Het
Other mutations in Igkv4-74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Igkv4-74 APN 6 69185060 missense probably damaging 1.00
R7462:Igkv4-74 UTSW 6 69185116 missense possibly damaging 0.80
R7729:Igkv4-74 UTSW 6 69184970 missense probably damaging 0.99
R8758:Igkv4-74 UTSW 6 69185327 frame shift probably null
R9508:Igkv4-74 UTSW 6 69184958 missense probably damaging 0.97
Z1176:Igkv4-74 UTSW 6 69185345 missense possibly damaging 0.77
Posted On 2016-08-02