Incidental Mutation 'IGL03166:Zfp868'
ID 411619
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp868
Ensembl Gene ENSMUSG00000060427
Gene Name zinc finger protein 868
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL03166
Quality Score
Status
Chromosome 8
Chromosomal Location 70063508-70078199 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 70064965 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tryptophan at position 123 (C123W)
Ref Sequence ENSEMBL: ENSMUSP00000113952 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074982] [ENSMUST00000121886]
AlphaFold Q3UTQ6
Predicted Effect probably damaging
Transcript: ENSMUST00000074982
AA Change: C123W

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074510
Gene: ENSMUSG00000060427
AA Change: C123W

DomainStartEndE-ValueType
KRAB 16 73 1.37e-12 SMART
low complexity region 83 94 N/A INTRINSIC
ZnF_C2H2 155 177 1.06e-4 SMART
ZnF_C2H2 183 205 1.1e-2 SMART
ZnF_C2H2 211 233 7.78e-3 SMART
ZnF_C2H2 239 261 1.36e-2 SMART
ZnF_C2H2 266 288 2.75e-3 SMART
ZnF_C2H2 294 316 4.79e-3 SMART
ZnF_C2H2 322 344 3.89e-3 SMART
ZnF_C2H2 350 372 5.5e-3 SMART
ZnF_C2H2 378 400 3.21e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000121886
AA Change: C123W

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113952
Gene: ENSMUSG00000060427
AA Change: C123W

DomainStartEndE-ValueType
KRAB 16 73 1.37e-12 SMART
low complexity region 83 94 N/A INTRINSIC
ZnF_C2H2 155 177 1.06e-4 SMART
ZnF_C2H2 183 205 1.1e-2 SMART
ZnF_C2H2 211 233 7.78e-3 SMART
ZnF_C2H2 239 261 1.36e-2 SMART
ZnF_C2H2 266 288 2.75e-3 SMART
ZnF_C2H2 294 316 4.79e-3 SMART
ZnF_C2H2 322 344 3.89e-3 SMART
ZnF_C2H2 350 372 5.5e-3 SMART
ZnF_C2H2 378 400 3.21e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150118
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1b A G 15: 101,100,959 (GRCm39) R374G probably damaging Het
Ankfn1 G T 11: 89,429,264 (GRCm39) A40D probably benign Het
Arhgap20 T A 9: 51,761,077 (GRCm39) I940K possibly damaging Het
Arhgap24 T C 5: 103,023,552 (GRCm39) probably benign Het
Bdp1 T C 13: 100,172,308 (GRCm39) T2103A probably benign Het
Cep350 A G 1: 155,739,346 (GRCm39) S2166P possibly damaging Het
Dlg2 T C 7: 91,549,938 (GRCm39) probably benign Het
Fhip2b A T 14: 70,827,616 (GRCm39) C160S probably damaging Het
Fyco1 A T 9: 123,657,452 (GRCm39) L908H probably benign Het
Gprc5b C A 7: 118,583,222 (GRCm39) A216S probably benign Het
Lamc1 A G 1: 153,208,047 (GRCm39) V80A probably benign Het
Lilra6 T C 7: 3,915,626 (GRCm39) I370V possibly damaging Het
Lim2 T A 7: 43,080,047 (GRCm39) C11* probably null Het
Lrp1b T A 2: 41,001,050 (GRCm39) H2058L probably damaging Het
Lrp3 G T 7: 34,901,905 (GRCm39) L659I probably benign Het
Lrrc8a T G 2: 30,145,377 (GRCm39) S64A probably benign Het
Lsr C T 7: 30,661,522 (GRCm39) probably null Het
Lyl1 C T 8: 85,429,300 (GRCm39) P3L possibly damaging Het
Man2c1 T A 9: 57,046,382 (GRCm39) V479E probably damaging Het
Mtf2 T A 5: 108,254,586 (GRCm39) D462E probably benign Het
Mx2 T C 16: 97,347,990 (GRCm39) I205T probably damaging Het
Nos1 T A 5: 118,052,517 (GRCm39) probably benign Het
Optc C T 1: 133,831,530 (GRCm39) probably benign Het
Or51e2 T C 7: 102,391,254 (GRCm39) N319D probably benign Het
Orm1 C A 4: 63,262,831 (GRCm39) probably benign Het
Pdzd8 T C 19: 59,288,940 (GRCm39) E820G probably damaging Het
Pkp1 A T 1: 135,805,862 (GRCm39) M612K probably damaging Het
Pno1 T A 11: 17,154,513 (GRCm39) probably null Het
Rbm34 T C 8: 127,697,606 (GRCm39) Q35R probably damaging Het
Ryr3 A T 2: 112,471,457 (GRCm39) Y4564* probably null Het
Slc34a3 T C 2: 25,122,186 (GRCm39) I140V probably damaging Het
Slc43a1 T C 2: 84,687,700 (GRCm39) I419T possibly damaging Het
Sltm C A 9: 70,450,251 (GRCm39) A17E possibly damaging Het
Smpdl3b T C 4: 132,468,842 (GRCm39) D125G probably benign Het
Snorc A C 1: 87,402,933 (GRCm39) probably benign Het
Supt3 G T 17: 45,234,106 (GRCm39) A48S probably damaging Het
Tlr3 A G 8: 45,855,965 (GRCm39) F72L probably benign Het
Trim36 T C 18: 46,345,388 (GRCm39) E15G probably benign Het
Tubb4b-ps1 A T 5: 7,229,965 (GRCm39) probably benign Het
Vmn2r68 T C 7: 84,871,331 (GRCm39) T651A probably benign Het
Wdr76 G T 2: 121,364,787 (GRCm39) V462F possibly damaging Het
Wnk2 C A 13: 49,224,520 (GRCm39) G1112* probably null Het
Zyg11b T A 4: 108,123,086 (GRCm39) M294L probably benign Het
Other mutations in Zfp868
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0546:Zfp868 UTSW 8 70,064,882 (GRCm39) missense probably benign 0.00
R1706:Zfp868 UTSW 8 70,065,060 (GRCm39) missense probably benign 0.27
R1741:Zfp868 UTSW 8 70,064,519 (GRCm39) missense probably damaging 1.00
R2119:Zfp868 UTSW 8 70,064,646 (GRCm39) nonsense probably null
R2336:Zfp868 UTSW 8 70,066,558 (GRCm39) splice site probably null
R3161:Zfp868 UTSW 8 70,064,736 (GRCm39) missense probably benign 0.01
R5847:Zfp868 UTSW 8 70,064,303 (GRCm39) missense probably damaging 1.00
R6361:Zfp868 UTSW 8 70,064,564 (GRCm39) missense probably damaging 1.00
R6753:Zfp868 UTSW 8 70,064,747 (GRCm39) missense probably benign 0.08
R6855:Zfp868 UTSW 8 70,064,230 (GRCm39) missense probably damaging 1.00
R8310:Zfp868 UTSW 8 70,066,446 (GRCm39) missense probably damaging 1.00
R8420:Zfp868 UTSW 8 70,064,160 (GRCm39) missense probably damaging 1.00
R8458:Zfp868 UTSW 8 70,064,559 (GRCm39) missense possibly damaging 0.57
R9066:Zfp868 UTSW 8 70,064,292 (GRCm39) missense probably damaging 1.00
Z1088:Zfp868 UTSW 8 70,064,561 (GRCm39) frame shift probably null
Z1176:Zfp868 UTSW 8 70,064,975 (GRCm39) missense possibly damaging 0.75
Posted On 2016-08-02