Incidental Mutation 'IGL03166:Sltm'
ID411636
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sltm
Ensembl Gene ENSMUSG00000032212
Gene NameSAFB-like, transcription modulator
Synonyms9130215G10Rik, 5730555F13Rik, 5730455C01Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.964) question?
Stock #IGL03166
Quality Score
Status
Chromosome9
Chromosomal Location70542754-70592234 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 70542969 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Glutamic Acid at position 17 (A17E)
Ref Sequence ENSEMBL: ENSMUSP00000149511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049263] [ENSMUST00000213808] [ENSMUST00000216816] [ENSMUST00000217593]
Predicted Effect unknown
Transcript: ENSMUST00000049263
AA Change: A17E
SMART Domains Protein: ENSMUSP00000049112
Gene: ENSMUSG00000032212
AA Change: A17E

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
SAP 22 56 2.49e-10 SMART
low complexity region 74 86 N/A INTRINSIC
coiled coil region 152 180 N/A INTRINSIC
low complexity region 318 330 N/A INTRINSIC
low complexity region 352 384 N/A INTRINSIC
RRM 385 458 2.06e-16 SMART
low complexity region 498 526 N/A INTRINSIC
low complexity region 536 552 N/A INTRINSIC
low complexity region 591 601 N/A INTRINSIC
coiled coil region 635 727 N/A INTRINSIC
low complexity region 824 853 N/A INTRINSIC
low complexity region 979 990 N/A INTRINSIC
low complexity region 1015 1028 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213362
Predicted Effect possibly damaging
Transcript: ENSMUST00000213808
AA Change: A17E

PolyPhen 2 Score 0.874 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215714
Predicted Effect unknown
Transcript: ENSMUST00000216816
AA Change: A17E
Predicted Effect probably benign
Transcript: ENSMUST00000217593
AA Change: A17E

PolyPhen 2 Score 0.183 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110079O15Rik A C 1: 87,475,211 probably benign Het
Acvr1b A G 15: 101,203,078 R374G probably damaging Het
Ankfn1 G T 11: 89,538,438 A40D probably benign Het
Arhgap20 T A 9: 51,849,777 I940K possibly damaging Het
Arhgap24 T C 5: 102,875,686 probably benign Het
Bdp1 T C 13: 100,035,800 T2103A probably benign Het
Cep350 A G 1: 155,863,600 S2166P possibly damaging Het
Dlg2 T C 7: 91,900,730 probably benign Het
Fam160b2 A T 14: 70,590,176 C160S probably damaging Het
Fyco1 A T 9: 123,828,387 L908H probably benign Het
Gprc5b C A 7: 118,983,999 A216S probably benign Het
Lamc1 A G 1: 153,332,301 V80A probably benign Het
Lilra6 T C 7: 3,912,627 I370V possibly damaging Het
Lim2 T A 7: 43,430,623 C11* probably null Het
Lrp1b T A 2: 41,111,038 H2058L probably damaging Het
Lrp3 G T 7: 35,202,480 L659I probably benign Het
Lrrc8a T G 2: 30,255,365 S64A probably benign Het
Lsr C T 7: 30,962,097 probably null Het
Lyl1 C T 8: 84,702,671 P3L possibly damaging Het
Man2c1 T A 9: 57,139,098 V479E probably damaging Het
Mtf2 T A 5: 108,106,720 D462E probably benign Het
Mx2 T C 16: 97,546,790 I205T probably damaging Het
Nos1 T A 5: 117,914,452 probably benign Het
Olfr78 T C 7: 102,742,047 N319D probably benign Het
Optc C T 1: 133,903,792 probably benign Het
Orm1 C A 4: 63,344,594 probably benign Het
Pdzd8 T C 19: 59,300,508 E820G probably damaging Het
Pkp1 A T 1: 135,878,124 M612K probably damaging Het
Pno1 T A 11: 17,204,513 probably null Het
Rbm34 T C 8: 126,970,856 Q35R probably damaging Het
Ryr3 A T 2: 112,641,112 Y4564* probably null Het
Slc34a3 T C 2: 25,232,174 I140V probably damaging Het
Slc43a1 T C 2: 84,857,356 I419T possibly damaging Het
Smpdl3b T C 4: 132,741,531 D125G probably benign Het
Supt3 G T 17: 44,923,219 A48S probably damaging Het
Tlr3 A G 8: 45,402,928 F72L probably benign Het
Trim36 T C 18: 46,212,321 E15G probably benign Het
Tubb4b-ps1 A T 5: 7,179,965 probably benign Het
Vmn2r68 T C 7: 85,222,123 T651A probably benign Het
Wdr76 G T 2: 121,534,306 V462F possibly damaging Het
Wnk2 C A 13: 49,071,044 G1112* probably null Het
Zfp868 A C 8: 69,612,314 C123W probably damaging Het
Zyg11b T A 4: 108,265,889 M294L probably benign Het
Other mutations in Sltm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Sltm APN 9 70579342 missense probably damaging 1.00
IGL01755:Sltm APN 9 70583922 splice site probably null
IGL01782:Sltm APN 9 70573641 missense probably damaging 1.00
IGL02441:Sltm APN 9 70587185 missense probably damaging 1.00
IGL02831:Sltm APN 9 70584865 missense probably damaging 1.00
IGL02947:Sltm APN 9 70591664 missense probably benign 0.05
R0288:Sltm UTSW 9 70579351 missense probably damaging 1.00
R0555:Sltm UTSW 9 70586081 missense probably damaging 1.00
R0815:Sltm UTSW 9 70561908 missense probably benign 0.04
R0863:Sltm UTSW 9 70561908 missense probably benign 0.04
R1315:Sltm UTSW 9 70543065 missense probably benign 0.13
R1533:Sltm UTSW 9 70586666 missense probably damaging 1.00
R1676:Sltm UTSW 9 70573647 missense probably damaging 1.00
R1764:Sltm UTSW 9 70561800 missense probably benign 0.00
R1845:Sltm UTSW 9 70543032 missense possibly damaging 0.60
R2049:Sltm UTSW 9 70581301 missense probably benign 0.00
R2163:Sltm UTSW 9 70591682 missense probably damaging 0.99
R3410:Sltm UTSW 9 70585958 missense probably damaging 0.97
R4323:Sltm UTSW 9 70580247 missense probably benign
R4632:Sltm UTSW 9 70579369 missense possibly damaging 0.86
R4748:Sltm UTSW 9 70581365 missense probably damaging 1.00
R4756:Sltm UTSW 9 70591610 missense possibly damaging 0.57
R4782:Sltm UTSW 9 70589057 missense probably damaging 1.00
R4799:Sltm UTSW 9 70589057 missense probably damaging 1.00
R4887:Sltm UTSW 9 70588978 missense probably damaging 1.00
R5221:Sltm UTSW 9 70579403 missense probably damaging 1.00
R5263:Sltm UTSW 9 70584799 missense unknown
R5982:Sltm UTSW 9 70586804 missense probably damaging 1.00
R6297:Sltm UTSW 9 70581359 missense probably damaging 0.99
R6456:Sltm UTSW 9 70542987 missense probably damaging 1.00
R6658:Sltm UTSW 9 70581362 missense probably damaging 1.00
R6720:Sltm UTSW 9 70573710 missense probably damaging 1.00
R6770:Sltm UTSW 9 70584777 missense unknown
R6923:Sltm UTSW 9 70574610 missense probably damaging 1.00
R7051:Sltm UTSW 9 70559066 missense probably damaging 1.00
R7166:Sltm UTSW 9 70584850 missense probably damaging 1.00
R7257:Sltm UTSW 9 70543965 splice site probably null
R7400:Sltm UTSW 9 70586070 missense probably damaging 1.00
R7438:Sltm UTSW 9 70573466 missense unknown
R7484:Sltm UTSW 9 70573897 missense unknown
R7630:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7631:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7632:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7633:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7862:Sltm UTSW 9 70572164 nonsense probably null
R7885:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7886:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7888:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7889:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7891:Sltm UTSW 9 70586673 missense possibly damaging 0.94
R7915:Sltm UTSW 9 70587149 missense probably damaging 1.00
R8030:Sltm UTSW 9 70585979 nonsense probably null
R8062:Sltm UTSW 9 70573497 missense unknown
R8099:Sltm UTSW 9 70586078 missense probably damaging 1.00
R8374:Sltm UTSW 9 70561945 missense probably null
R8698:Sltm UTSW 9 70587070 missense probably benign 0.27
Posted On2016-08-02