Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03166:Tubb4b-ps1'

411637

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tubb4b-ps1

Ensembl Gene

ENSMUSG00000095159

Gene Name

tubulin, beta 4B class IVB, pseudogene 1

Synonyms

Tubb2c-ps1, Tubb2c2, ENSMUSG00000056506

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL03166

Quality Score

Status

Chromosome

Chromosomal Location

7229365-7230700 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to T at 7229965 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143568 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000200317]

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000082917

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000179460

SMART Domains

Protein: ENSMUSP00000136922
Gene: ENSMUSG00000095159

Domain	Start	End	E-Value	Type
Tubulin	47	243	6.6e-61	SMART
Tubulin_C	245	382	4.17e-49	SMART
low complexity region	427	444	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000200317

SMART Domains

Protein: ENSMUSP00000143568
Gene: ENSMUSG00000092094

Domain	Start	End	E-Value	Type
ZnF_C2H2	56	80	2e-2	SMART
low complexity region	958	970	N/A	INTRINSIC
low complexity region	1155	1179	N/A	INTRINSIC
low complexity region	1196	1207	N/A	INTRINSIC
low complexity region	1215	1234	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvr1b	A	G	15: 101,100,959 (GRCm39)	R374G	probably damaging	Het
Ankfn1	G	T	11: 89,429,264 (GRCm39)	A40D	probably benign	Het
Arhgap20	T	A	9: 51,761,077 (GRCm39)	I940K	possibly damaging	Het
Arhgap24	T	C	5: 103,023,552 (GRCm39)		probably benign	Het
Bdp1	T	C	13: 100,172,308 (GRCm39)	T2103A	probably benign	Het
Cep350	A	G	1: 155,739,346 (GRCm39)	S2166P	possibly damaging	Het
Dlg2	T	C	7: 91,549,938 (GRCm39)		probably benign	Het
Fhip2b	A	T	14: 70,827,616 (GRCm39)	C160S	probably damaging	Het
Fyco1	A	T	9: 123,657,452 (GRCm39)	L908H	probably benign	Het
Gprc5b	C	A	7: 118,583,222 (GRCm39)	A216S	probably benign	Het
Lamc1	A	G	1: 153,208,047 (GRCm39)	V80A	probably benign	Het
Lilra6	T	C	7: 3,915,626 (GRCm39)	I370V	possibly damaging	Het
Lim2	T	A	7: 43,080,047 (GRCm39)	C11*	probably null	Het
Lrp1b	T	A	2: 41,001,050 (GRCm39)	H2058L	probably damaging	Het
Lrp3	G	T	7: 34,901,905 (GRCm39)	L659I	probably benign	Het
Lrrc8a	T	G	2: 30,145,377 (GRCm39)	S64A	probably benign	Het
Lsr	C	T	7: 30,661,522 (GRCm39)		probably null	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Man2c1	T	A	9: 57,046,382 (GRCm39)	V479E	probably damaging	Het
Mtf2	T	A	5: 108,254,586 (GRCm39)	D462E	probably benign	Het
Mx2	T	C	16: 97,347,990 (GRCm39)	I205T	probably damaging	Het
Nos1	T	A	5: 118,052,517 (GRCm39)		probably benign	Het
Optc	C	T	1: 133,831,530 (GRCm39)		probably benign	Het
Or51e2	T	C	7: 102,391,254 (GRCm39)	N319D	probably benign	Het
Orm1	C	A	4: 63,262,831 (GRCm39)		probably benign	Het
Pdzd8	T	C	19: 59,288,940 (GRCm39)	E820G	probably damaging	Het
Pkp1	A	T	1: 135,805,862 (GRCm39)	M612K	probably damaging	Het
Pno1	T	A	11: 17,154,513 (GRCm39)		probably null	Het
Rbm34	T	C	8: 127,697,606 (GRCm39)	Q35R	probably damaging	Het
Ryr3	A	T	2: 112,471,457 (GRCm39)	Y4564*	probably null	Het
Slc34a3	T	C	2: 25,122,186 (GRCm39)	I140V	probably damaging	Het
Slc43a1	T	C	2: 84,687,700 (GRCm39)	I419T	possibly damaging	Het
Sltm	C	A	9: 70,450,251 (GRCm39)	A17E	possibly damaging	Het
Smpdl3b	T	C	4: 132,468,842 (GRCm39)	D125G	probably benign	Het
Snorc	A	C	1: 87,402,933 (GRCm39)		probably benign	Het
Supt3	G	T	17: 45,234,106 (GRCm39)	A48S	probably damaging	Het
Tlr3	A	G	8: 45,855,965 (GRCm39)	F72L	probably benign	Het
Trim36	T	C	18: 46,345,388 (GRCm39)	E15G	probably benign	Het
Vmn2r68	T	C	7: 84,871,331 (GRCm39)	T651A	probably benign	Het
Wdr76	G	T	2: 121,364,787 (GRCm39)	V462F	possibly damaging	Het
Wnk2	C	A	13: 49,224,520 (GRCm39)	G1112*	probably null	Het
Zfp868	A	C	8: 70,064,965 (GRCm39)	C123W	probably damaging	Het
Zyg11b	T	A	4: 108,123,086 (GRCm39)	M294L	probably benign	Het

Other mutations in Tubb4b-ps1

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL00973:Tubb4b-ps1	APN	5	7,229,408 (GRCm39)	intron	probably benign
IGL01861:Tubb4b-ps1	APN	5	7,229,374 (GRCm39)	intron	probably benign
IGL01980:Tubb4b-ps1	APN	5	7,229,843 (GRCm39)	intron	probably benign
IGL02336:Tubb4b-ps1	APN	5	7,229,952 (GRCm39)	intron	probably benign
IGL03152:Tubb4b-ps1	APN	5	7,230,001 (GRCm39)	intron	probably benign
IGL03279:Tubb4b-ps1	APN	5	7,229,630 (GRCm39)	intron	probably benign

Posted On

2016-08-02