Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03167:Vmn2r117'

411662

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL03167

Quality Score

Status

Chromosome

Chromosomal Location

23459675-23479597 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23477707 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 242 (V242A)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

probably damaging
Transcript: ENSMUST00000171996
AA Change: V242A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: V242A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agbl3	A	C	6: 34,857,659	K921T	possibly damaging	Het
Agtpbp1	A	T	13: 59,532,080		probably benign	Het
Ankrd22	A	T	19: 34,165,774	M1K	probably null	Het
Ano5	G	A	7: 51,585,511	V698I	probably damaging	Het
Ccnh	A	G	13: 85,197,566		probably benign	Het
Col15a1	A	T	4: 47,282,635	I771F	probably damaging	Het
Dmrt1	T	C	19: 25,545,893	S203P	possibly damaging	Het
Exoc5	A	T	14: 49,051,345	V82E	probably damaging	Het
Ffar3	A	T	7: 30,855,355	V180E	probably damaging	Het
Fhad1	T	C	4: 141,972,797	S381G	probably benign	Het
Foxf1	C	A	8: 121,084,908	Y170*	probably null	Het
Glis1	A	G	4: 107,435,905	D75G	possibly damaging	Het
Gpr151	T	C	18: 42,578,374	H413R	probably benign	Het
Gtf3c1	T	C	7: 125,670,580		probably null	Het
Htt	T	A	5: 34,818,986	F711I	probably damaging	Het
Il1rapl1	A	G	X: 86,747,261	I691T	possibly damaging	Het
Iqgap2	T	C	13: 95,684,898	Y579C	probably benign	Het
Lingo3	A	G	10: 80,835,344	S251P	probably damaging	Het
Mbl1	T	A	14: 41,158,586	S144T	probably benign	Het
Musk	A	T	4: 58,366,821	R462W	possibly damaging	Het
Mynn	T	C	3: 30,609,042	L373P	probably damaging	Het
Myoz2	G	A	3: 123,006,490	R230*	probably null	Het
Nup35	A	G	2: 80,658,316		probably benign	Het
Olfr1032	T	A	2: 86,008,167	Y130*	probably null	Het
Olfr305	C	T	7: 86,363,920	C139Y	probably damaging	Het
Olfr710	A	G	7: 106,944,645	S119P	probably damaging	Het
Olfr987	C	T	2: 85,331,320	D193N	probably benign	Het
Pira2	A	T	7: 3,840,920	S618T	probably damaging	Het
Plch1	G	A	3: 63,722,744		probably benign	Het
Pparg	T	G	6: 115,473,227	F396V	probably damaging	Het
Scaper	T	C	9: 55,859,824	E441G	probably damaging	Het
Serpinb2	T	A	1: 107,522,755	C161S	probably benign	Het
Skint5	C	T	4: 113,893,850	E333K	unknown	Het
Slc22a8	C	T	19: 8,609,958	P461S	probably damaging	Het
Slc38a6	C	T	12: 73,350,537	Q318*	probably null	Het
Sycp2	T	C	2: 178,379,498	K512E	probably damaging	Het
Tas2r103	T	A	6: 133,036,660	N148Y	probably damaging	Het
Tcf7l1	A	G	6: 72,632,996	M257T	possibly damaging	Het
Tert	T	A	13: 73,640,000	N792K	probably damaging	Het
Thada	A	T	17: 84,458,849	V43E	probably damaging	Het
Trabd2b	T	C	4: 114,609,998	S475P	probably benign	Het
Ypel3	A	T	7: 126,780,075	I107F	probably damaging	Het
Zfp352	T	C	4: 90,224,702	S360P	probably damaging	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23477840	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23475429	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23479546	missense	probably benign
IGL01078:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23477804	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23478382	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23477241	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23475382	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23477225	missense	possibly damaging	0.65
IGL02612:Vmn2r117	APN	17	23459784	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23475578	splice site	probably benign
R0315:Vmn2r117	UTSW	17	23460165	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23475514	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23475503	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23460553	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23478473	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23477455	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23478389	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23477480	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23477644	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23460256	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23459911	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23459856	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23460378	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23460415	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23460106	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23459877	missense	probably damaging	1.00
R4658:Vmn2r117	UTSW	17	23478416	missense	probably benign	0.01
R4881:Vmn2r117	UTSW	17	23477885	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23459838	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23479513	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23460148	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23477874	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23477202	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23479561	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23460114	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23460219	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23460049	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23478308	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23479563	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23477203	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23475385	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23475565	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23460133	missense	probably benign	0.25
R7443:Vmn2r117	UTSW	17	23460345	missense	probably damaging	1.00
R7449:Vmn2r117	UTSW	17	23459895	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23477291	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23460126	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23479407	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23477770	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23460537	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23479468	missense	probably benign
R8723:Vmn2r117	UTSW	17	23477369	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23460169	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23460471	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23459944	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23477615	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23477604	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23478476	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23477840	missense	probably damaging	1.00
V5622:Vmn2r117	UTSW	17	23479505	missense	possibly damaging	0.67
Z1176:Vmn2r117	UTSW	17	23459766	missense	probably benign	0.00

Posted On

2016-08-02