Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03167:Ankrd22'

411664

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ankrd22

Ensembl Gene

ENSMUSG00000024774

Gene Name

ankyrin repeat domain 22

Synonyms

D19Ertd675e, 5430429D21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL03167

Quality Score

Status

Chromosome

Chromosomal Location

34099949-34143441 bp(-) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

A to T at 34143174 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 1 (M1K)

Ref Sequence

ENSEMBL: ENSMUSP00000025686 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025686]

AlphaFold

Q9D3J5

Predicted Effect

probably null
Transcript: ENSMUST00000025686
AA Change: M1K

PolyPhen 2 Score 0.771 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000025686
Gene: ENSMUSG00000024774
AA Change: M1K

Domain	Start	End	E-Value	Type
ANK	39	68	1.1e-6	SMART
ANK	72	130	2.05e2	SMART
ANK	134	163	1.68e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159887

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agbl3	A	C	6: 34,834,594 (GRCm39)	K921T	possibly damaging	Het
Agtpbp1	A	T	13: 59,679,894 (GRCm39)		probably benign	Het
Ano5	G	A	7: 51,235,259 (GRCm39)	V698I	probably damaging	Het
Ccnh	A	G	13: 85,345,685 (GRCm39)		probably benign	Het
Col15a1	A	T	4: 47,282,635 (GRCm39)	I771F	probably damaging	Het
Dmrt1	T	C	19: 25,523,257 (GRCm39)	S203P	possibly damaging	Het
Exoc5	A	T	14: 49,288,802 (GRCm39)	V82E	probably damaging	Het
Ffar3	A	T	7: 30,554,780 (GRCm39)	V180E	probably damaging	Het
Fhad1	T	C	4: 141,700,108 (GRCm39)	S381G	probably benign	Het
Foxf1	C	A	8: 121,811,647 (GRCm39)	Y170*	probably null	Het
Glis1	A	G	4: 107,293,102 (GRCm39)	D75G	possibly damaging	Het
Gpr151	T	C	18: 42,711,439 (GRCm39)	H413R	probably benign	Het
Gtf3c1	T	C	7: 125,269,752 (GRCm39)		probably null	Het
Htt	T	A	5: 34,976,330 (GRCm39)	F711I	probably damaging	Het
Il1rapl1	A	G	X: 85,790,867 (GRCm39)	I691T	possibly damaging	Het
Iqgap2	T	C	13: 95,821,406 (GRCm39)	Y579C	probably benign	Het
Lingo3	A	G	10: 80,671,178 (GRCm39)	S251P	probably damaging	Het
Mbl1	T	A	14: 40,880,543 (GRCm39)	S144T	probably benign	Het
Musk	A	T	4: 58,366,821 (GRCm39)	R462W	possibly damaging	Het
Mynn	T	C	3: 30,663,191 (GRCm39)	L373P	probably damaging	Het
Myoz2	G	A	3: 122,800,139 (GRCm39)	R230*	probably null	Het
Nup35	A	G	2: 80,488,660 (GRCm39)		probably benign	Het
Or14a259	C	T	7: 86,013,128 (GRCm39)	C139Y	probably damaging	Het
Or2d4	A	G	7: 106,543,852 (GRCm39)	S119P	probably damaging	Het
Or5ak4	C	T	2: 85,161,664 (GRCm39)	D193N	probably benign	Het
Or5m3	T	A	2: 85,838,511 (GRCm39)	Y130*	probably null	Het
Pira2	A	T	7: 3,843,919 (GRCm39)	S618T	probably damaging	Het
Plch1	G	A	3: 63,630,165 (GRCm39)		probably benign	Het
Pparg	T	G	6: 115,450,188 (GRCm39)	F396V	probably damaging	Het
Scaper	T	C	9: 55,767,108 (GRCm39)	E441G	probably damaging	Het
Serpinb2	T	A	1: 107,450,485 (GRCm39)	C161S	probably benign	Het
Skint5	C	T	4: 113,751,047 (GRCm39)	E333K	unknown	Het
Slc22a8	C	T	19: 8,587,322 (GRCm39)	P461S	probably damaging	Het
Slc38a6	C	T	12: 73,397,311 (GRCm39)	Q318*	probably null	Het
Sycp2	T	C	2: 178,021,291 (GRCm39)	K512E	probably damaging	Het
Tas2r103	T	A	6: 133,013,623 (GRCm39)	N148Y	probably damaging	Het
Tcf7l1	A	G	6: 72,609,979 (GRCm39)	M257T	possibly damaging	Het
Tert	T	A	13: 73,788,119 (GRCm39)	N792K	probably damaging	Het
Thada	A	T	17: 84,766,277 (GRCm39)	V43E	probably damaging	Het
Trabd2b	T	C	4: 114,467,195 (GRCm39)	S475P	probably benign	Het
Vmn2r117	A	G	17: 23,696,681 (GRCm39)	V242A	probably damaging	Het
Ypel3	A	T	7: 126,379,247 (GRCm39)	I107F	probably damaging	Het
Zfp352	T	C	4: 90,112,939 (GRCm39)	S360P	probably damaging	Het

Other mutations in Ankrd22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01153:Ankrd22	APN	19	34,106,229 (GRCm39)	missense	probably damaging	1.00
IGL02800:Ankrd22	APN	19	34,143,181 (GRCm39)	utr 5 prime	probably benign
R1993:Ankrd22	UTSW	19	34,143,174 (GRCm39)	start codon destroyed	probably null	0.77
R4659:Ankrd22	UTSW	19	34,102,968 (GRCm39)	missense	probably damaging	0.98
R4906:Ankrd22	UTSW	19	34,126,752 (GRCm39)	missense	possibly damaging	0.91
R6216:Ankrd22	UTSW	19	34,101,569 (GRCm39)	splice site	probably null
R6881:Ankrd22	UTSW	19	34,126,782 (GRCm39)	missense	probably damaging	1.00
R7468:Ankrd22	UTSW	19	34,126,692 (GRCm39)	missense	possibly damaging	0.95
R7526:Ankrd22	UTSW	19	34,126,765 (GRCm39)	missense	possibly damaging	0.93
R9082:Ankrd22	UTSW	19	34,126,662 (GRCm39)	missense	probably damaging	0.99
Z1177:Ankrd22	UTSW	19	34,100,891 (GRCm39)	frame shift	probably null

Posted On

2016-08-02