Incidental Mutation 'IGL03167:Tas2r103'
ID 411679
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r103
Ensembl Gene ENSMUSG00000030196
Gene Name taste receptor, type 2, member 103
Synonyms TRB2, T2R3, mGR03, mt2r63, Tas2r10, Tas2r3, EG667992
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL03167
Quality Score
Status
Chromosome 6
Chromosomal Location 133013126-133014064 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 133013623 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 148 (N148Y)
Ref Sequence ENSEMBL: ENSMUSP00000032317 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032317]
AlphaFold Q9JKA3
Predicted Effect probably damaging
Transcript: ENSMUST00000032317
AA Change: N148Y

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000032317
Gene: ENSMUSG00000030196
AA Change: N148Y

DomainStartEndE-ValueType
Pfam:TAS2R 5 301 1.5e-79 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl3 A C 6: 34,834,594 (GRCm39) K921T possibly damaging Het
Agtpbp1 A T 13: 59,679,894 (GRCm39) probably benign Het
Ankrd22 A T 19: 34,143,174 (GRCm39) M1K probably null Het
Ano5 G A 7: 51,235,259 (GRCm39) V698I probably damaging Het
Ccnh A G 13: 85,345,685 (GRCm39) probably benign Het
Col15a1 A T 4: 47,282,635 (GRCm39) I771F probably damaging Het
Dmrt1 T C 19: 25,523,257 (GRCm39) S203P possibly damaging Het
Exoc5 A T 14: 49,288,802 (GRCm39) V82E probably damaging Het
Ffar3 A T 7: 30,554,780 (GRCm39) V180E probably damaging Het
Fhad1 T C 4: 141,700,108 (GRCm39) S381G probably benign Het
Foxf1 C A 8: 121,811,647 (GRCm39) Y170* probably null Het
Glis1 A G 4: 107,293,102 (GRCm39) D75G possibly damaging Het
Gpr151 T C 18: 42,711,439 (GRCm39) H413R probably benign Het
Gtf3c1 T C 7: 125,269,752 (GRCm39) probably null Het
Htt T A 5: 34,976,330 (GRCm39) F711I probably damaging Het
Il1rapl1 A G X: 85,790,867 (GRCm39) I691T possibly damaging Het
Iqgap2 T C 13: 95,821,406 (GRCm39) Y579C probably benign Het
Lingo3 A G 10: 80,671,178 (GRCm39) S251P probably damaging Het
Mbl1 T A 14: 40,880,543 (GRCm39) S144T probably benign Het
Musk A T 4: 58,366,821 (GRCm39) R462W possibly damaging Het
Mynn T C 3: 30,663,191 (GRCm39) L373P probably damaging Het
Myoz2 G A 3: 122,800,139 (GRCm39) R230* probably null Het
Nup35 A G 2: 80,488,660 (GRCm39) probably benign Het
Or14a259 C T 7: 86,013,128 (GRCm39) C139Y probably damaging Het
Or2d4 A G 7: 106,543,852 (GRCm39) S119P probably damaging Het
Or5ak4 C T 2: 85,161,664 (GRCm39) D193N probably benign Het
Or5m3 T A 2: 85,838,511 (GRCm39) Y130* probably null Het
Pira2 A T 7: 3,843,919 (GRCm39) S618T probably damaging Het
Plch1 G A 3: 63,630,165 (GRCm39) probably benign Het
Pparg T G 6: 115,450,188 (GRCm39) F396V probably damaging Het
Scaper T C 9: 55,767,108 (GRCm39) E441G probably damaging Het
Serpinb2 T A 1: 107,450,485 (GRCm39) C161S probably benign Het
Skint5 C T 4: 113,751,047 (GRCm39) E333K unknown Het
Slc22a8 C T 19: 8,587,322 (GRCm39) P461S probably damaging Het
Slc38a6 C T 12: 73,397,311 (GRCm39) Q318* probably null Het
Sycp2 T C 2: 178,021,291 (GRCm39) K512E probably damaging Het
Tcf7l1 A G 6: 72,609,979 (GRCm39) M257T possibly damaging Het
Tert T A 13: 73,788,119 (GRCm39) N792K probably damaging Het
Thada A T 17: 84,766,277 (GRCm39) V43E probably damaging Het
Trabd2b T C 4: 114,467,195 (GRCm39) S475P probably benign Het
Vmn2r117 A G 17: 23,696,681 (GRCm39) V242A probably damaging Het
Ypel3 A T 7: 126,379,247 (GRCm39) I107F probably damaging Het
Zfp352 T C 4: 90,112,939 (GRCm39) S360P probably damaging Het
Other mutations in Tas2r103
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02230:Tas2r103 APN 6 133,014,019 (GRCm39) missense possibly damaging 0.86
IGL02332:Tas2r103 APN 6 133,013,475 (GRCm39) missense probably benign 0.21
IGL03122:Tas2r103 APN 6 133,013,872 (GRCm39) missense probably damaging 1.00
R0380:Tas2r103 UTSW 6 133,013,166 (GRCm39) missense probably damaging 1.00
R0671:Tas2r103 UTSW 6 133,013,313 (GRCm39) missense probably benign 0.01
R1700:Tas2r103 UTSW 6 133,013,774 (GRCm39) missense probably damaging 1.00
R2098:Tas2r103 UTSW 6 133,013,560 (GRCm39) missense probably benign
R3977:Tas2r103 UTSW 6 133,013,280 (GRCm39) missense probably benign 0.16
R3979:Tas2r103 UTSW 6 133,013,280 (GRCm39) missense probably benign 0.16
R3980:Tas2r103 UTSW 6 133,013,280 (GRCm39) missense probably benign 0.16
R4924:Tas2r103 UTSW 6 133,013,161 (GRCm39) missense probably benign 0.02
R5779:Tas2r103 UTSW 6 133,013,908 (GRCm39) missense probably benign 0.02
R5839:Tas2r103 UTSW 6 133,013,779 (GRCm39) missense probably benign 0.06
R6265:Tas2r103 UTSW 6 133,013,494 (GRCm39) missense probably damaging 1.00
R7768:Tas2r103 UTSW 6 133,013,812 (GRCm39) missense probably benign 0.06
R8851:Tas2r103 UTSW 6 133,013,896 (GRCm39) missense
R9435:Tas2r103 UTSW 6 133,013,686 (GRCm39) nonsense probably null
Posted On 2016-08-02