Incidental Mutation 'IGL03168:Olfr198'
ID411708
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr198
Ensembl Gene ENSMUSG00000052537
Gene Nameolfactory receptor 198
SynonymsGA_x54KRFPKG5P-55416332-55415412, MOR182-8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL03168
Quality Score
Status
Chromosome16
Chromosomal Location59200352-59203533 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 59202247 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 60 (Y60H)
Ref Sequence ENSEMBL: ENSMUSP00000146813 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064452] [ENSMUST00000208244]
Predicted Effect probably damaging
Transcript: ENSMUST00000064452
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000065535
Gene: ENSMUSG00000052537
AA Change: Y60H

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 4.9e-45 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208244
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c6 T C 13: 4,436,281 V29A probably benign Het
Ankk1 C A 9: 49,415,768 A704S possibly damaging Het
Aph1c G A 9: 66,833,337 probably benign Het
Arglu1 T A 8: 8,683,960 I119L probably benign Het
Brwd1 A T 16: 96,017,677 S1318R possibly damaging Het
Chd3 A G 11: 69,348,915 probably benign Het
Colq T C 14: 31,524,420 Y445C probably damaging Het
Cyp2a4 A T 7: 26,313,550 probably benign Het
Cyp2j7 C T 4: 96,230,037 M106I probably benign Het
Erfe T G 1: 91,371,442 N302K probably damaging Het
Fam26d C T 10: 34,041,556 V300I probably benign Het
Fggy A T 4: 95,926,809 probably benign Het
Gata3 A G 2: 9,868,814 Y290H probably damaging Het
Grik4 T C 9: 42,671,243 T136A probably damaging Het
Hc G T 2: 35,024,198 N832K probably benign Het
Jhy A T 9: 40,917,552 S353T possibly damaging Het
Krt40 T A 11: 99,543,028 Q44L possibly damaging Het
Ksr2 T C 5: 117,748,781 F794S probably damaging Het
Olfr1094 A G 2: 86,829,263 I170M possibly damaging Het
Olfr1178 A G 2: 88,391,594 M116V probably damaging Het
Olfr138 A C 17: 38,274,791 S7R probably damaging Het
Olfr166 A T 16: 19,487,219 H127L probably benign Het
Olfr905 A G 9: 38,473,019 T91A probably benign Het
Pcdhb17 A G 18: 37,485,772 E205G probably benign Het
Pon3 A T 6: 5,256,177 I17K possibly damaging Het
Prkd2 A G 7: 16,850,263 D347G possibly damaging Het
Prkdc A G 16: 15,834,166 I3806V probably benign Het
Qpct C A 17: 79,052,324 A20E unknown Het
Rap1a A G 3: 105,750,271 S11P probably damaging Het
Rnf145 C A 11: 44,555,158 T273K probably damaging Het
Speg T C 1: 75,388,187 I298T probably damaging Het
Syt6 G A 3: 103,587,627 V303M probably damaging Het
Tpr A G 1: 150,408,757 I324M probably benign Het
Uggt2 A G 14: 119,077,668 F330L probably damaging Het
Unc45a A T 7: 80,333,133 L348Q probably damaging Het
Vmn1r17 T A 6: 57,360,598 I212F probably benign Het
Vmn2r68 A C 7: 85,221,764 N770K probably damaging Het
Zfhx3 T C 8: 108,946,500 V1394A probably damaging Het
Other mutations in Olfr198
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Olfr198 APN 16 59202097 missense possibly damaging 0.94
IGL03053:Olfr198 APN 16 59202247 missense probably damaging 1.00
R1355:Olfr198 UTSW 16 59201680 missense probably damaging 1.00
R1370:Olfr198 UTSW 16 59201680 missense probably damaging 1.00
R1510:Olfr198 UTSW 16 59202183 missense probably damaging 0.99
R1777:Olfr198 UTSW 16 59202016 missense probably benign 0.35
R1962:Olfr198 UTSW 16 59201908 missense possibly damaging 0.88
R1964:Olfr198 UTSW 16 59201908 missense possibly damaging 0.88
R5409:Olfr198 UTSW 16 59201557 missense probably damaging 1.00
R5642:Olfr198 UTSW 16 59202006 missense probably damaging 1.00
R5704:Olfr198 UTSW 16 59202006 missense probably damaging 1.00
R6323:Olfr198 UTSW 16 59202282 missense probably damaging 1.00
R6829:Olfr198 UTSW 16 59201535 missense probably damaging 1.00
R7315:Olfr198 UTSW 16 59202133 missense probably benign 0.00
R7738:Olfr198 UTSW 16 59201955 missense probably benign 0.00
Posted On2016-08-02