Incidental Mutation 'IGL03170:Vmn1r21'
| ID |
411791 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r21
|
| Ensembl Gene |
ENSMUSG00000115343 |
| Gene Name |
vomeronasal 1 receptor 21 |
| Synonyms |
V1rc28 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.121)
|
| Stock # |
IGL03170
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
57820549-57821442 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 57820847 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 199
(V199A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154295
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081186]
[ENSMUST00000203310]
[ENSMUST00000203488]
[ENSMUST00000226191]
|
| AlphaFold |
Q8R2C6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000081186
AA Change: V199A
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000079950
Gene: ENSMUSG00000058588
AA Change: V199A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203270
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203310
AA Change: V199A
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000145398
Gene: ENSMUSG00000115343
AA Change: V199A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
27 |
107 |
1.8e-14 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203488
AA Change: V199A
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000144978
Gene: ENSMUSG00000115343
AA Change: V199A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
105 |
2e-13 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000226191
AA Change: V199A
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cand2 |
A |
G |
6: 115,774,861 (GRCm39) |
D1023G |
probably damaging |
Het |
| Ccn1 |
C |
A |
3: 145,355,514 (GRCm39) |
A12S |
probably benign |
Het |
| Cyp2c54 |
A |
G |
19: 40,060,809 (GRCm39) |
|
probably null |
Het |
| Cyp4f37 |
C |
T |
17: 32,844,093 (GRCm39) |
|
probably benign |
Het |
| Entpd2 |
T |
C |
2: 25,289,493 (GRCm39) |
F325S |
probably damaging |
Het |
| Flnb |
T |
C |
14: 7,818,261 (GRCm38) |
I37T |
possibly damaging |
Het |
| Gtpbp10 |
A |
G |
5: 5,605,355 (GRCm39) |
V116A |
probably benign |
Het |
| H2-T9 |
C |
T |
17: 36,439,605 (GRCm39) |
G125E |
probably damaging |
Het |
| Lrp1b |
T |
A |
2: 40,587,456 (GRCm39) |
N164I |
unknown |
Het |
| Nle1 |
T |
A |
11: 82,795,096 (GRCm39) |
T312S |
probably benign |
Het |
| Or10ab5 |
T |
C |
7: 108,245,307 (GRCm39) |
I159V |
probably benign |
Het |
| Pim1 |
T |
A |
17: 29,710,152 (GRCm39) |
L12Q |
possibly damaging |
Het |
| Plb1 |
G |
T |
5: 32,442,246 (GRCm39) |
C246F |
probably damaging |
Het |
| Ppp4r4 |
T |
C |
12: 103,557,033 (GRCm39) |
|
probably benign |
Het |
| Prl6a1 |
T |
A |
13: 27,499,406 (GRCm39) |
V63D |
possibly damaging |
Het |
| Ptprz1 |
G |
A |
6: 22,959,766 (GRCm39) |
A88T |
probably benign |
Het |
| Ranbp3l |
A |
T |
15: 9,029,611 (GRCm39) |
E31V |
probably damaging |
Het |
| Relch |
C |
T |
1: 105,663,680 (GRCm39) |
T943I |
probably damaging |
Het |
| Rgs9 |
G |
A |
11: 109,150,681 (GRCm39) |
T209I |
probably benign |
Het |
| Smg8 |
A |
G |
11: 86,977,434 (GRCm39) |
V49A |
probably damaging |
Het |
| Smim6 |
A |
T |
11: 115,804,314 (GRCm39) |
T34S |
possibly damaging |
Het |
| Snw1 |
T |
G |
12: 87,519,022 (GRCm39) |
T4P |
probably benign |
Het |
| Sod2 |
C |
A |
17: 13,227,257 (GRCm39) |
H70Q |
probably benign |
Het |
| Tro |
A |
G |
X: 149,438,556 (GRCm39) |
S34P |
probably benign |
Het |
| Tshr |
T |
A |
12: 91,504,643 (GRCm39) |
M527K |
probably damaging |
Het |
| Uggt1 |
A |
C |
1: 36,202,342 (GRCm39) |
V1085G |
probably damaging |
Het |
| Xkr9 |
T |
C |
1: 13,771,036 (GRCm39) |
I184T |
possibly damaging |
Het |
| Zfp369 |
T |
C |
13: 65,442,224 (GRCm39) |
S273P |
probably damaging |
Het |
| Zpld2 |
C |
T |
4: 133,920,345 (GRCm39) |
V607I |
possibly damaging |
Het |
|
| Other mutations in Vmn1r21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00329:Vmn1r21
|
APN |
6 |
57,821,049 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01366:Vmn1r21
|
APN |
6 |
57,820,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01660:Vmn1r21
|
APN |
6 |
57,821,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02864:Vmn1r21
|
APN |
6 |
57,820,661 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02961:Vmn1r21
|
APN |
6 |
57,820,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4453001:Vmn1r21
|
UTSW |
6 |
57,821,307 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1800:Vmn1r21
|
UTSW |
6 |
57,820,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1928:Vmn1r21
|
UTSW |
6 |
57,821,077 (GRCm39) |
nonsense |
probably null |
|
|
R3407:Vmn1r21
|
UTSW |
6 |
57,820,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5566:Vmn1r21
|
UTSW |
6 |
57,821,079 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6012:Vmn1r21
|
UTSW |
6 |
57,820,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6293:Vmn1r21
|
UTSW |
6 |
57,821,255 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6473:Vmn1r21
|
UTSW |
6 |
57,820,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7128:Vmn1r21
|
UTSW |
6 |
57,820,936 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7489:Vmn1r21
|
UTSW |
6 |
57,820,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7559:Vmn1r21
|
UTSW |
6 |
57,821,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8002:Vmn1r21
|
UTSW |
6 |
57,821,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8218:Vmn1r21
|
UTSW |
6 |
57,820,910 (GRCm39) |
missense |
noncoding transcript |
|
|
R8467:Vmn1r21
|
UTSW |
6 |
57,821,441 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R8922:Vmn1r21
|
UTSW |
6 |
57,820,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8930:Vmn1r21
|
UTSW |
6 |
57,820,998 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8932:Vmn1r21
|
UTSW |
6 |
57,820,998 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8961:Vmn1r21
|
UTSW |
6 |
57,820,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Vmn1r21
|
UTSW |
6 |
57,821,348 (GRCm39) |
missense |
probably benign |
0.36 |
|
Z1176:Vmn1r21
|
UTSW |
6 |
57,820,563 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2016-08-02 |
Incidental Mutation