Incidental Mutation 'IGL03170:Vmn1r21'
ID411791
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r21
Ensembl Gene ENSMUSG00000115343
Gene Namevomeronasal 1 receptor 21
SynonymsV1rc28
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.135) question?
Stock #IGL03170
Quality Score
Status
Chromosome6
Chromosomal Location57842830-57850343 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 57843862 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 199 (V199A)
Ref Sequence ENSEMBL: ENSMUSP00000154295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081186] [ENSMUST00000203310] [ENSMUST00000203488] [ENSMUST00000226191]
Predicted Effect probably damaging
Transcript: ENSMUST00000081186
AA Change: V199A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000079950
Gene: ENSMUSG00000058588
AA Change: V199A

DomainStartEndE-ValueType
Pfam:V1R 28 293 5.9e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203270
Predicted Effect probably damaging
Transcript: ENSMUST00000203310
AA Change: V199A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145398
Gene: ENSMUSG00000115343
AA Change: V199A

DomainStartEndE-ValueType
Pfam:V1R 27 107 1.8e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203488
AA Change: V199A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000144978
Gene: ENSMUSG00000115343
AA Change: V199A

DomainStartEndE-ValueType
Pfam:V1R 28 105 2e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226191
AA Change: V199A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310035C23Rik C T 1: 105,735,955 T943I probably damaging Het
Cand2 A G 6: 115,797,900 D1023G probably damaging Het
Cyp2c54 A G 19: 40,072,365 probably null Het
Cyp4f37 C T 17: 32,625,119 probably benign Het
Cyr61 C A 3: 145,649,759 A12S probably benign Het
Entpd2 T C 2: 25,399,481 F325S probably damaging Het
Flnb T C 14: 7,818,261 I37T possibly damaging Het
Gm7030 C T 17: 36,128,713 G125E probably damaging Het
Gm7534 C T 4: 134,193,034 V607I possibly damaging Het
Gtpbp10 A G 5: 5,555,355 V116A probably benign Het
Lrp1b T A 2: 40,697,444 N164I unknown Het
Nle1 T A 11: 82,904,270 T312S probably benign Het
Olfr509 T C 7: 108,646,100 I159V probably benign Het
Pim1 T A 17: 29,491,178 L12Q possibly damaging Het
Plb1 G T 5: 32,284,902 C246F probably damaging Het
Ppp4r4 T C 12: 103,590,774 probably benign Het
Prl6a1 T A 13: 27,315,423 V63D possibly damaging Het
Ptprz1 G A 6: 22,959,767 A88T probably benign Het
Ranbp3l A T 15: 9,000,787 E31V probably damaging Het
Rgs9 G A 11: 109,259,855 T209I probably benign Het
Smg8 A G 11: 87,086,608 V49A probably damaging Het
Smim6 A T 11: 115,913,488 T34S possibly damaging Het
Snw1 T G 12: 87,472,252 T4P probably benign Het
Sod2 C A 17: 13,008,370 H70Q probably benign Het
Tro A G X: 150,655,560 S34P probably benign Het
Tshr T A 12: 91,537,869 M527K probably damaging Het
Uggt1 A C 1: 36,163,261 V1085G probably damaging Het
Xkr9 T C 1: 13,700,812 I184T possibly damaging Het
Zfp369 T C 13: 65,294,410 S273P probably damaging Het
Other mutations in Vmn1r21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00329:Vmn1r21 APN 6 57844064 missense probably benign 0.05
IGL01366:Vmn1r21 APN 6 57843814 missense probably benign 0.01
IGL01660:Vmn1r21 APN 6 57844237 missense probably damaging 0.99
IGL02864:Vmn1r21 APN 6 57843676 missense probably benign 0.13
IGL02961:Vmn1r21 APN 6 57843989 missense probably benign 0.01
PIT4453001:Vmn1r21 UTSW 6 57844322 missense probably benign 0.04
R1800:Vmn1r21 UTSW 6 57843814 missense probably benign 0.01
R1928:Vmn1r21 UTSW 6 57844092 nonsense probably null
R3407:Vmn1r21 UTSW 6 57843892 missense probably damaging 1.00
R5566:Vmn1r21 UTSW 6 57844094 missense probably benign 0.06
R6012:Vmn1r21 UTSW 6 57843906 missense probably damaging 1.00
R6293:Vmn1r21 UTSW 6 57844270 missense probably benign 0.19
R6473:Vmn1r21 UTSW 6 57843598 missense probably damaging 0.99
R7128:Vmn1r21 UTSW 6 57843951 missense probably damaging 0.97
R7489:Vmn1r21 UTSW 6 57843892 missense probably damaging 1.00
R7559:Vmn1r21 UTSW 6 57844242 missense probably damaging 0.99
R8002:Vmn1r21 UTSW 6 57844214 missense probably benign 0.00
Z1176:Vmn1r21 UTSW 6 57843578 missense probably benign 0.01
Posted On2016-08-02