Incidental Mutation 'IGL03170:Prl6a1'
ID 411802
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl6a1
Ensembl Gene ENSMUSG00000069259
Gene Name prolactin family 6, subfamily a, member 1
Synonyms PLP-B, Prlpb
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # IGL03170
Quality Score
Status
Chromosome 13
Chromosomal Location 27496610-27503235 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 27499406 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 63 (V63D)
Ref Sequence ENSEMBL: ENSMUSP00000089268 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091679] [ENSMUST00000091680]
AlphaFold O35257
Predicted Effect possibly damaging
Transcript: ENSMUST00000091679
AA Change: V63D

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000089268
Gene: ENSMUSG00000069259
AA Change: V63D

DomainStartEndE-ValueType
low complexity region 4 15 N/A INTRINSIC
Pfam:Hormone_1 21 235 8e-65 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000091680
AA Change: V58D

PolyPhen 2 Score 0.913 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000089269
Gene: ENSMUSG00000069259
AA Change: V58D

DomainStartEndE-ValueType
Pfam:Hormone_1 16 230 1.1e-61 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119758
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cand2 A G 6: 115,774,861 (GRCm39) D1023G probably damaging Het
Ccn1 C A 3: 145,355,514 (GRCm39) A12S probably benign Het
Cyp2c54 A G 19: 40,060,809 (GRCm39) probably null Het
Cyp4f37 C T 17: 32,844,093 (GRCm39) probably benign Het
Entpd2 T C 2: 25,289,493 (GRCm39) F325S probably damaging Het
Flnb T C 14: 7,818,261 (GRCm38) I37T possibly damaging Het
Gtpbp10 A G 5: 5,605,355 (GRCm39) V116A probably benign Het
H2-T9 C T 17: 36,439,605 (GRCm39) G125E probably damaging Het
Lrp1b T A 2: 40,587,456 (GRCm39) N164I unknown Het
Nle1 T A 11: 82,795,096 (GRCm39) T312S probably benign Het
Or10ab5 T C 7: 108,245,307 (GRCm39) I159V probably benign Het
Pim1 T A 17: 29,710,152 (GRCm39) L12Q possibly damaging Het
Plb1 G T 5: 32,442,246 (GRCm39) C246F probably damaging Het
Ppp4r4 T C 12: 103,557,033 (GRCm39) probably benign Het
Ptprz1 G A 6: 22,959,766 (GRCm39) A88T probably benign Het
Ranbp3l A T 15: 9,029,611 (GRCm39) E31V probably damaging Het
Relch C T 1: 105,663,680 (GRCm39) T943I probably damaging Het
Rgs9 G A 11: 109,150,681 (GRCm39) T209I probably benign Het
Smg8 A G 11: 86,977,434 (GRCm39) V49A probably damaging Het
Smim6 A T 11: 115,804,314 (GRCm39) T34S possibly damaging Het
Snw1 T G 12: 87,519,022 (GRCm39) T4P probably benign Het
Sod2 C A 17: 13,227,257 (GRCm39) H70Q probably benign Het
Tro A G X: 149,438,556 (GRCm39) S34P probably benign Het
Tshr T A 12: 91,504,643 (GRCm39) M527K probably damaging Het
Uggt1 A C 1: 36,202,342 (GRCm39) V1085G probably damaging Het
Vmn1r21 A G 6: 57,820,847 (GRCm39) V199A probably damaging Het
Xkr9 T C 1: 13,771,036 (GRCm39) I184T possibly damaging Het
Zfp369 T C 13: 65,442,224 (GRCm39) S273P probably damaging Het
Zpld2 C T 4: 133,920,345 (GRCm39) V607I possibly damaging Het
Other mutations in Prl6a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01124:Prl6a1 APN 13 27,500,347 (GRCm39) missense possibly damaging 0.72
IGL01688:Prl6a1 APN 13 27,501,969 (GRCm39) missense probably damaging 1.00
IGL01922:Prl6a1 APN 13 27,499,343 (GRCm39) missense possibly damaging 0.57
IGL02059:Prl6a1 APN 13 27,499,348 (GRCm39) missense probably benign 0.02
R0027:Prl6a1 UTSW 13 27,502,011 (GRCm39) missense probably damaging 1.00
R0027:Prl6a1 UTSW 13 27,502,011 (GRCm39) missense probably damaging 1.00
R0049:Prl6a1 UTSW 13 27,501,980 (GRCm39) missense probably damaging 0.99
R0606:Prl6a1 UTSW 13 27,498,177 (GRCm39) intron probably benign
R0944:Prl6a1 UTSW 13 27,502,149 (GRCm39) splice site probably benign
R1518:Prl6a1 UTSW 13 27,502,911 (GRCm39) missense probably null 0.19
R1518:Prl6a1 UTSW 13 27,502,910 (GRCm39) missense possibly damaging 0.72
R1566:Prl6a1 UTSW 13 27,499,410 (GRCm39) missense possibly damaging 0.84
R1621:Prl6a1 UTSW 13 27,501,993 (GRCm39) missense probably benign 0.01
R2011:Prl6a1 UTSW 13 27,499,352 (GRCm39) missense probably benign 0.00
R2058:Prl6a1 UTSW 13 27,503,081 (GRCm39) missense probably benign 0.05
R2937:Prl6a1 UTSW 13 27,499,303 (GRCm39) missense probably damaging 0.98
R3079:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense possibly damaging 0.71
R4685:Prl6a1 UTSW 13 27,500,307 (GRCm39) missense probably benign 0.00
R4856:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense probably damaging 0.98
R4886:Prl6a1 UTSW 13 27,502,983 (GRCm39) missense probably damaging 0.98
R5495:Prl6a1 UTSW 13 27,496,654 (GRCm39) missense possibly damaging 0.95
R5923:Prl6a1 UTSW 13 27,500,346 (GRCm39) missense probably benign 0.08
R6772:Prl6a1 UTSW 13 27,503,031 (GRCm39) missense probably damaging 1.00
R7411:Prl6a1 UTSW 13 27,502,125 (GRCm39) missense probably damaging 1.00
R7501:Prl6a1 UTSW 13 27,500,282 (GRCm39) missense possibly damaging 0.69
R7549:Prl6a1 UTSW 13 27,502,954 (GRCm39) missense probably damaging 0.96
R7563:Prl6a1 UTSW 13 27,498,221 (GRCm39) critical splice donor site probably null
R7773:Prl6a1 UTSW 13 27,502,125 (GRCm39) missense probably damaging 1.00
R8024:Prl6a1 UTSW 13 27,502,678 (GRCm39) intron probably benign
R8994:Prl6a1 UTSW 13 27,499,417 (GRCm39) missense probably benign 0.01
R9129:Prl6a1 UTSW 13 27,502,064 (GRCm39) missense
R9395:Prl6a1 UTSW 13 27,499,400 (GRCm39) missense possibly damaging 0.71
Z1177:Prl6a1 UTSW 13 27,499,304 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02